List of works - Deborah M Muoio

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.

scientific article

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults

scientific article published on 13 December 2012

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth

scientific article

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

scientific article published on 9 October 2015

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

scientific article

Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

scientific article

Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance ⬇️

scientific article published on 18 March 2010

Bicarbonate alters cellular responses in respiration assays.

scientific article published on 27 May 2017

Biomedicine. Insulin resistance takes a trip through the ER.

scientific article published in October 2004

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

scientific article published on July 2015

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

scientific article published on 24 June 2009

Carnitine revisited: potential use as adjunctive treatment in diabetes.

scientific article published on 20 February 2007

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis

scientific article

Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts

scientific article

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

scientific article published on 18 October 2006

Diabetes: The good in fat.

scientific article published on 19 November 2014

Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans

scientific article published on 15 January 2014

Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments

scientific article published on January 2012

Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction

scientific article

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion

scientific article

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

scientific article

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach

scientific article

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

scientific article

Fatty acid oxidation and insulin action: when less is more

scientific article published in June 2008

Genome-wide chromatin state transitions associated with developmental and environmental cues

scientific article

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

scholarly article

Glucose uptake in muscle cell cultures from endurance-trained men.

scientific article published on April 2005

Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation

scientific article published on August 2013

HDAC3 sets the timer on muscle fuel switching

scientific article published on 01 February 2017

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

scientific article

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

scientific article published on 8 February 2004

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research

scientific article published on 5 October 2012

Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates

scientific article

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha

scientific article published on 26 February 2009

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

scientific article

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

scientific article published on 3 June 2010

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase

scientific article published on 28 May 2009

Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

scientific article published on December 2009

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA

scientific article published on 2 September 2010

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

scientific article published on 01 August 1997

Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression

scientific article

Lipid-induced mitochondrial stress and insulin action in muscle

scientific article

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition

scientific article published on August 2009

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

scientific article

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

scientific article

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

scientific article published on 04 October 2015

Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock

scientific article published on December 2014

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

scientific article published on 22 October 2008

Metabolic profiling of muscle contraction in lean compared with obese rodents

scientific article

Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.

scientific article

Metabolism and vascular fatty acid transport

scientific article

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

scientific article

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

scientific article published on 5 November 2015

Metabolomic analysis of insulin resistance across different mouse strains and diets.

scientific article published on 5 October 2017

Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans

scientific article published on 10 April 2015

Metabolomics applied to diabetes research: moving from information to knowledge

scientific article

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs

scientific journal article

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

scientific article published on January 2008

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

scientific article published on 23 January 2017

Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy

scientific article

Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction

scientific article published on 24 November 2014

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

scientific article

Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice

scientific article published on 26 October 2020

Obesity and lipid stress inhibit carnitine acetyltransferase activity

scientific article published on 06 January 2014

Obesity-related derangements in metabolic regulation

scientific article

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

scientific article published on 21 November 2012

Peripheral metabolic actions of leptin

scientific article

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells

scientific article published in April 2002

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency

scientific article published on 3 August 2005

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals ⬇️

scientific article

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction

scientific article

Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model

publication published on 11 March 2022

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit

scientific article published on April 2015

Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.

scientific article published on 14 October 2011

Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs

scientific article

Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road ⬇️

scientific article published on June 3, 2012

SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control

scientific article published on September 2015

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

scientific article

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

scientific journal article

Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects

scientific article

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease

scientific article published on October 2007

Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism

scientific article published on 12 January 2005

Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood

scientific article

TXNIP Links Redox Circuitry to Glucose Control

scientific article published on 01 June 2007

Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

scientific article published on 30 January 2014

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins

scientific article published on 30 December 2015

The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women

scientific article published on 01 October 2000

The Failing Heart Relies on Ketone Bodies as a Fuel

scientific article published on 27 January 2016

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain

scientific article published on February 2009

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice

scientific article

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

scientific article published on 11 June 2015

List of works by Deborah M Muoio

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.

A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance ⬇️

Bicarbonate alters cellular responses in respiration assays.

Biomedicine. Insulin resistance takes a trip through the ER.

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

Carnitine revisited: potential use as adjunctive treatment in diabetes.

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis

Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

Diabetes: The good in fat.

Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans

Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments

Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

Fatty acid oxidation and insulin action: when less is more

Genome-wide chromatin state transitions associated with developmental and environmental cues

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

Glucose uptake in muscle cell cultures from endurance-trained men.

Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation

HDAC3 sets the timer on muscle fuel switching

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research

Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase

Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression

Lipid-induced mitochondrial stress and insulin action in muscle

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

Metabolic profiling of muscle contraction in lean compared with obese rodents

Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.

Metabolism and vascular fatty acid transport

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

Metabolomic analysis of insulin resistance across different mouse strains and diets.

Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans

Metabolomics applied to diabetes research: moving from information to knowledge

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy

Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice

Obesity and lipid stress inhibit carnitine acetyltransferase activity

Obesity-related derangements in metabolic regulation

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

Peripheral metabolic actions of leptin

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals ⬇️

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction

Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit

Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.

Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs

Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road ⬇️

SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase