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List of works by Ernesto Canalis

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis

scientific article

A soluble activin type IIA receptor induces bone formation and improves skeletal integrity

scholarly article

A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength ⬇️

scientific article published on July 3, 2012

AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts

scientific article

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor

scientific article published on 07 February 2014

Activation of Nfatc2 in osteoblasts causes osteopenia

scientific article

Age-related changes in trabecular architecture differ in female and male C57BL/6J mice

scientific article published in August 2007

An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice

scientific article published on 31 January 2017

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice

scientific article published on 12 June 2019

Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome

scientific article published on 28 January 2020

BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat.

scientific article

Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss

scientific article published on December 2009

Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site

scientific article

Bone morphogenetic proteins and their antagonists

scientific article

Bone morphogenetic proteins, their antagonists, and the skeleton

scientific article

C/EBP homologous protein is necessary for normal osteoblastic function.

scientific article published in February 2006

CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia

scientific article published on 7 November 2006

CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation

scientific article published on 18 December 2003

Canonical Notch activation in osteocytes causes osteopetrosis

scientific article

Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders

scientific article published on 24 August 2017

Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation

scientific article

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

scientific article

Conditional inactivation of noggin in the postnatal skeleton causes osteopenia

scientific article published on 14 February 2012

Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage

scientific article

Connective tissue growth factor enhances osteoblastogenesis in vitro

scientific article published on 25 June 2008

Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage

scientific article

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice

scientific article

Correction to: Notch in skeletal physiology and disease

scientific article published on 01 January 2019

Cortisol regulates the expression of Notch in osteoblasts

scientific article

Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice

scientific article

Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity

scientific article published on January 2014

Drug-induced Osteoporosis: Mechanisms and Clinical Implications ⬇️

scientific article published on October 1, 2010

Effects of Sex and Notch Signaling on the Osteocyte Cell Pool

scientific article published on 18 May 2016

Effects of activated T cells on osteoclastogenesis depend on how they are activated

scientific article published on September 2004

Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression

scientific article

Effects of glucocorticoids on the skeleton.

scientific article

Expression and regulation of CCN genes in murine osteoblasts

scientific article published on 28 November 2005

Gene delivery by retroviruses

scientific article

Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes

scientific article published in August 2007

Glucocorticoid-induced osteoporosis in rheumatic diseases

scientific article

Glucocorticoid-induced osteoporosis: an update

scientific article

Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects

scientific article

Glucocorticoids inhibit notch target gene expression in osteoblasts

scientific article published on 25 March 2018

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis

scientific article

Growth factor control of bone mass

scientific article

Growth hormone, insulin-like growth factors, and the skeleton

scientific article published on 24 April 2008

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass ⬇️

scientific article published on November 17, 2010

Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice

scientific article published on 26 December 2016

Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice

scientific article published on 19 June 2013

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

scientific article

Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations

scientific article published on 30 May 2016

Hajdu-Cheney syndrome: a review

scientific article

Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss

scientific article

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis

scientific article published on 12 March 2018

Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls

scientific article published in June 2003

MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis

scientific article published on 7 November 2017

Management of endocrine disease: Secondary osteoporosis: pathophysiology and management

scientific article

Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease

scientific article

Mechanisms of anabolic therapies for osteoporosis

scientific article published on August 2007

Mechanisms of glucocorticoid action in bone

scientific article

Mechanisms of glucocorticoid-induced osteoporosis

scientific article

Misexpression of CCAAT/enhancer binding protein beta causes osteopenia

scientific article published on 13 February 2009

Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling

scientific article published on February 2012

Nemo-like kinase regulates postnatal skeletal homeostasis

scientific article

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis

scientific article

Nephroblastoma overexpressed (Nov) induces gremlin in ST‐2 stromal cell lines by post‐transcriptional mechanisms ⬇️

scientific article published on February 1, 2011

Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia

scientific article

Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist

scientific article

New treatment modalities in osteoporosis

scientific article published on September 2010

Notch 1 impairs osteoblastic cell differentiation

scientific article published on 4 September 2003

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling

scientific article published on 6 January 2006

Notch Signaling and the Skeleton

scientific article published on 13 April 2016

Notch and the skeleton

scientific article

Notch in skeletal physiology and disease

scientific article published on 07 September 2018

Notch inhibits osteoblast differentiation and causes osteopenia

scientific article published on 17 April 2008

Notch regulation of bone development and remodeling and related skeletal disorders

scientific article

Notch signaling in osteoblasts

scientific article published on 29 April 2008

Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling

scientific journal article

Notch signaling in skeletal health and disease

scientific article published on 8 May 2013

Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes

scientific article published on 21 December 2012

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture

scientific article published on 04 February 2014

Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis

scientific article published on 24 April 2020

Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo

scientific article published on 16 July 2018

Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts

scientific article published on 19 November 2012

Osteoblast lineage-specific effects of notch activation in the skeleton

scientific article published on 28 December 2012

Osteonectin-Null Mutation Compromises Osteoblast Formation, Maturation, and Survival ⬇️

scientific article published on June 1, 2003

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro

scientific article published on 26 May 2005

PPARG by dietary fat interaction influences bone mass in mice and humans

scientific article published on September 2008

Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes

scientific article

Perspectives on glucocorticoid-induced osteoporosis

scientific article published on April 2004

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism

scientific article published on 20 May 2019

Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts ⬇️

scientific article published on December 3, 2010

Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage.

scientific article

Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions

scientific article published on August 2009

Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells

scientific article published on 28 January 2014

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia

scientific article published on 5 June 2008

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

scientific article published on 7 June 2017

The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele

scientific article published on 12 October 2015

The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone

scientific article published on 13 October 2017

The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α

scientific article published on 01 August 2019

The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton

scientific article

The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton.

scientific article published in December 2011

The lateral meningocele syndrome mutation causes marked osteopenia in mice.

scientific article published on 24 July 2018

Transcriptional regulation of collagenase‐3 by interleukin‐1 alpha in osteoblasts ⬇️

scientific article published on December 1, 2003

Transgenic overexpression of gremlin results in developmental defects in enamel and dentin in mice

scientific article

Treatment of glucocorticoid-induced osteoporosis ⬇️

scientific article published on February 1, 2009

Update in new anabolic therapies for osteoporosis

scientific article

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

scientific article published on 13 August 2013

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