List of works - Eiichi Kodama

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

scientific article published in January 2007

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

scientific article

A simple, rapid, and sensitive system for the evaluation of anti-viral drugs in rats

scientific article published on 23 June 2012

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

scientific article published on 4 June 2007

Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants

article

Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

scientific article

Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir

scientific article published on 01 January 2020

Binding of multivalent anionic porphyrins to V3 loop fragments of an HIV-1 envelope and their antiviral activity

scientific article published in April 2010

Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group

scientific article published on 13 October 2009

Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

scientific article published on 15 September 2009

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

scientific article

Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates.

scientific article published on May 2003

Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat

scientific article

Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

scientific article

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

scientific article published on 01 February 2020

Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study

scientific article published in 2024

Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus

scientific article published on 6 June 2009

Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity

scientific article published on 16 January 2008

Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20

scientific article published on 10 December 2008

Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides

scientific article published on January 2004

Development and application of fluorescent SDF-1 derivatives

scientific article published on May 2012

Development of a novel fusion inhibitor against T-20-resistant HIV-1.

scientific article published in January 2009

Dual-reporter phenotypic assay for human immunodeficiency viruses

scientific article

Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

scientific article published on 07 October 2013

Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide

scientific article published on 10 September 2008

Elvitegravir: a new HIV integrase inhibitor

scientific article published on 19 October 2009

Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs

scientific article published on 24 June 2013

HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains

scientific article published on 20 May 2013

Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway

scientific article

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.

scientific article published on 24 June 2013

Identification of minimal sequence for HIV-1 fusion inhibitors

scientific article published on 10 September 2008

Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach

scientific article published on 29 May 2008

K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism

scientific article

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.

scientific article published on December 2009

Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design

scientific article

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics

scientific article published on March 2006

Novel patterns of nevirapine resistance-associated mutations of human immunodeficiency virus type 1 in treatment-naïve patients

scientific article published in October 2004

Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.

scientific article published on 12 June 2008

Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues

scientific article

Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects on T-20

scientific article

Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication.

scientific article published on 11 August 2010

RNase S complex bearing arginine-rich peptide and anti-HIV activity.

scientific article published in March 2005

Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors

scientific article

Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

scientific article published on 16 May 2010

SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide

scientific article published on 29 December 2008

Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives.

scientific article published on February 2005

Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides

scientific article published on December 2004

Study profile of The Tohoku Medical Megabank Community-Based Cohort Study

scientific article published on 11 January 2020

Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide

scientific article

Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4.

scientific article

Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

scientific article

The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.

scientific article

X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution

scientific article

List of works by Eiichi Kodama

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

A simple, rapid, and sensitive system for the evaluation of anti-viral drugs in rats

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants

Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir

Binding of multivalent anionic porphyrins to V3 loop fragments of an HIV-1 envelope and their antiviral activity

Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group

Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

Broad spectrum anti-RNA virus activities of titanium and vanadium substituted polyoxotungstates.

Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat

Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study

Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus

Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity

Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20

Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides

Development and application of fluorescent SDF-1 derivatives

Development of a novel fusion inhibitor against T-20-resistant HIV-1.

Dual-reporter phenotypic assay for human immunodeficiency viruses

Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide

Elvitegravir: a new HIV integrase inhibitor

Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs

HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains

Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.

Identification of minimal sequence for HIV-1 fusion inhibitors

Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach

K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.

Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics

Novel patterns of nevirapine resistance-associated mutations of human immunodeficiency virus type 1 in treatment-naïve patients

Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.

Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues

Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects on T-20

Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication.

RNase S complex bearing arginine-rich peptide and anti-HIV activity.

Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors

Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide

Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives.

Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides

Study profile of The Tohoku Medical Megabank Community-Based Cohort Study

Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide

Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4.

Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.

X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution