List of works by Zhiguang Zhou

A new screening strategy and whole-exome sequencing for the early diagnosis of maturity-onset diabetes of the young

scientific article published on 04 July 2020

A rare hereditary and metastatic paraganglioma involved in both spermatic cord and testis

scientific article published on 23 February 2019

Abnormal DNA methylation in CD4+ T cells from people with latent autoimmune diabetes in adults.

scientific article

Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial

scientific article published on 18 October 2013

Adding vitamin D3 to the dipeptidyl peptidase-4 inhibitor saxagliptin has the potential to protect β-cell function in LADA patients: A 1-year pilot study

scientific article published on 10 February 2020

Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy.

scientific article published on 17 January 2017

Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages.

scientific article published on 30 January 2018

Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1.

scientific article

Albuminuria: Prevalence, associated risk factors and relationship with cardiovascular disease

scientific article

Alteration of regulatory T cells in type 1 diabetes mellitus: a comprehensive review.

scientific article published on October 2014

Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults.

scientific article

Altered T-cell subsets and transcription factors in latent autoimmune diabetes in adults taking sitagliptin, a dipeptidyl peptidase-4 inhibitor: A 1-year open-label randomized controlled trial

scientific article published on 03 August 2018

Angiopoietin-like protein 3 and adiponectin levels in patients with metabolic syndrome.

scientific article published in March 2010

Anti-apoptotic function and mechanism of ginseng saponins in Rattus pancreatic β-cells.

scientific article published on January 2012

Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases.

scientific article published on 15 November 2016

Association between family history risk categories and prevalence of diabetes in Chinese population

scientific article

Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population

scientific article

Autoantibodies to CCL3 are of low sensitivity and specificity for the diagnosis of type 1 diabetes

scientific article published on 21 February 2012

Beyond Genetics: What Causes Type 1 Diabetes

scientific article published on 22 November 2016

Blockade of dopamine D1-like receptor signalling protects mice against OVA-induced acute asthma by inhibiting B-cell activating transcription factor signalling and Th17 function.

scientific article published on 25 October 2013

Bone mineral density spectrum in individuals with type 1 diabetes, LADA, and type 2 diabetes

scientific article published on 03 August 2020

Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function

scientific article published on 3 January 2018

Cardiovascular disease in patients with type 1 diabetes: early evaluation, risk factors and possible relation with cardiac autoimmunity

scientific article published on 30 November 2020

Change of serum soluble CD14 level in newly diagnosed type 2 diabetes and its significance

scientific article published on July 2010

Changes of Regulatory T Cells in the Early Stage of Obesity Mice and Their Modulation on Macrophage Subtypes in Visceral Adipose Tissue.

scientific article

Chlamydia-secreted protease CPAF degrades host antimicrobial peptides

scientific article published on 06 March 2015

Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology

scientific article

Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight

scientific article

Circulating circular RNAs profiles associated with type 1 diabetes

scientific article published on 15 August 2020

Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes

scientific article

Clinical heterogeneity of type 1 diabetes (T1D) found in Asia.

scientific article published on 19 May 2017

Comparative effectiveness and safety of different basal insulins in a real-world setting.

scientific article published on 3 April 2017

Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha

scientific article published on 18 September 2018

Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls

scientific article published on 01 November 2011

Comparison of effects between IL-2 and IL-7 on glutamic acid decarboxylase 65 reactive T cell responses in patients with Type 1 diabetes

scientific article published in November 2017

Comparison of insulin intensification strategies with insulin lispro low mixture twice daily versus basal insulin glargine and prandial insulin lispro once daily in East Asian and Caucasian patients with type 2 diabetes mellitus

scientific article

Comparison of the effects on glycaemic control and β-cell function in newly diagnosed type 2 diabetes patients of treatment with exenatide, insulin or pioglitazone: a multicentre randomized parallel-group trial (the CONFIDENCE study).

scientific article

Complicated curve association of body weight at diagnosis with C-peptide in children and adults with new-onset type 1 diabetes

scientific article published on 07 January 2020

Continuous spectrum of glucose dysmetabolism due to the KCNJ11 gene mutation-Case reports and review of the literature

scientific article published on 15 September 2020

Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus

scientific article (publication date: 5 September 2015)

Dapagliflozin as add-on therapy in Asian patients with type 2 diabetes inadequately controlled on insulin with or without oral antihyperglycemic drugs: A randomized controlled trial.

scientific article published on 7 December 2017

Diabetes self-management, depressive symptoms, metabolic control and satisfaction with quality of life over time in Chinese youth with type 1 diabetes.

scientific article published on 26 September 2014

Diabetes self-management, depressive symptoms, quality of life and metabolic control in youth with type 1 diabetes in China.

scientific article published on 26 October 2012

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection.

scientific article published on 28 July 2012

Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus

scientific article published on 16 October 2020

Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus

scientific article

Dipeptidyl peptidase 4 inhibitor sitagliptin maintains β-cell function in patients with recent-onset latent autoimmune diabetes in adults: one year prospective study

scientific article published on 16 January 2014

Dipeptidyl peptidase-4 inhibitors: multitarget drugs, not only antidiabetes drugs.

scientific article published on 19 June 2013

Dipeptidyl peptidase-4(DPP-4) inhibitors: promising new agents for autoimmune diabetes

scientific article published on 17 July 2018

Direct medical costs for patients with type 2 diabetes in 16 tertiary hospitals in urban China: A multicenter prospective cohort study.

scientific article

Discordant association of islet autoantibodies with high-risk HLA genes in Chinese type 1 diabetes.

scientific article

Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes

scientific article published on 19 October 2011

Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes

scientific article published on 25 September 2018

Distinct two different ages associated with clinical profiles of acute onset type 1 diabetes in Chinese patients

scientific article published on 09 August 2019

Effect of high-fat or high-glucose diet on obesity and visceral adipose tissue in mice.

scientific article published in December 2014

Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.

scientific article published in May 2008

Effectiveness of Lilly Connected Care Program (LCCP) App-Based Diabetes Education for Patients With Type 2 Diabetes Treated With Insulin: Retrospective Real-World Study

scientific article published on 06 March 2020

Effects of hepatic insulin gene therapy on enteric neuropathy in STZ-diabetic mice

scientific article published in June 2011

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis.

scientific article

Efficacy and safety of lixisenatide in a predominantly Asian population with type 2 diabetes insufficiently controlled with basal insulin: The GetGoal-L-C randomized trial

scientific article published on 25 July 2017

Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy (STRATEGY): a multicenter, randomized, controlled, non-inferiority clinical trial.

scientific article published on 7 February 2017

Efficacy and safety of traditional chinese medicine for diabetes: a double-blind, randomised, controlled trial

scientific article

Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes

scientific article published on 26 June 2018

Emerging roles of dipeptidyl peptidase 4 inhibitors: anti-inflammatory and immunomodulatory effect and its application in diabetes mellitus.

scientific article published on 14 July 2014

Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity

scientific article published on 07 January 2011

Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells

scientific article

Exploration of Users' Perspectives and Needs and Design of a Type 1 Diabetes Management Mobile App: Mixed-Methods Study

scientific article published on 21 September 2018

Factors Influencing Patients' Intentions to Use Diabetes Management Apps Based on an Extended Unified Theory of Acceptance and Use of Technology Model: Web-Based Survey

scientific article published on 13 August 2019

Frequency, Clinical Characteristics and Determinants of Partial Remission in Type 1 Diabetes: Different Patterns in Children and Adults

scientific article published on 06 April 2020

From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?

scientific article published on 01 December 2008

Fulminant type 1 diabetes caused by peginterferon α-2a therapy in hepatitis C.

scientific article published on 19 December 2017

Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition

scientific article published on 29 March 2020

Fulminant type 1 diabetes: a collaborative clinical cases investigation in China.

scientific article published on 23 December 2011

GLP-1 receptor agonists and pancreatic safety concerns in type 2 diabetic patients: data from cardiovascular outcome trials

scientific article published on 26 February 2020

GLP-1 receptor agonists and risk of cancer in type 2 diabetes: an updated meta-analysis of randomized controlled trials

scientific article published on 16 August 2019

Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5.

scientific article

Glycemic control is related to cognitive dysfunction in Chinese children with type 1 diabetes mellitus

scientific article published on 28 May 2018

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

scientific article

HLA Genetic Discrepancy Between Latent Autoimmune Diabetes in Adults and Type 1 Diabetes: LADA China Study No. 6

scientific article published on 11 February 2016

Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance

scientific article published on 23 February 2017

Hyperglycemia and blood pressure treatment goal: a cross sectional survey of 18350 patients with type 2 diabetes in 77 tertiary hospitals in China

scientific article

Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China

scientific article published on 25 June 2014

IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice

scientific article

Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study

scientific article published on 31 May 2019

Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8

scientific article published on 27 September 2018

Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis

scientific article published on 6 December 2011

Immunological Aspects of Fulminant Type 1 Diabetes in Chinese.

scientific article published on 14 February 2016

Impact of waist circumference and body mass index on risk of cardiometabolic disorder and cardiovascular disease in Chinese adults: a national diabetes and metabolic disorders survey

scientific article

Incidence and trend of type 1 diabetes and the underlying environmental determinants

scientific article published on 11 October 2018

Incidence of type 1 diabetes in China, 2010-13: population based study.

scientific article published on 3 January 2018

Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes

scientific article published on 04 August 2014

Induction of protective immunity against Chlamydia muridarum intracervical infection in DBA/1j mice.

scientific article

Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese

scientific article published on 16 May 2010

Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity.

scientific article published on 13 April 2015

Lack of long-lasting hydrosalpinx in A/J mice correlates with rapid but transient chlamydial ascension and neutrophil recruitment in the oviduct following intravaginal inoculation with Chlamydia muridarum

scientific article

Latent autoimmune diabetes in adults with low-titer GAD antibodies: similar disease progression with type 2 diabetes: a nationwide, multicenter prospective study (LADA China Study 3).

scientific article published on 21 October 2014

Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease.

scientific article published on 10 July 2014

Lixisenatide treatment improves glycaemic control in Asian patients with type 2 diabetes mellitus inadequately controlled on metformin with or without sulfonylurea: a randomized, double-blind, placebo-controlled, 24-week trial (GetGoal-M-Asia).

scientific article published in November 2014

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

scientific article published on 6 June 2013

Loss of Mbd2 Protects Mice Against High-Fat Diet-Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure

scientific article published on 23 August 2016

Medical care and payment for diabetes in China: enormous threat and great opportunity.

scientific article

Metabolic syndrome in adult-onset latent autoimmune diabetes.

scientific article published in January 2005

Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co-culture microenviroment.

scientific article published on 14 October 2015

Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy

scientific article published on 20 February 2014

Metformin shows anti-inflammatory effects in murine macrophages through Dicer/microribonucleic acid-34a-5p and microribonucleic acid-125b-5p

scientific article published on 25 June 2019

Molecular mechanisms in autoimmune type 1 diabetes: a critical review.

scientific article published on October 2014

Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF.

scientific article published on 16 July 2016

Neutrophils in type 1 diabetes

scientific article

Non-pharmaceutical factors for poor glycemic control in 13,970 Chinese women with drug-treated type 2 diabetes: a cross-sectional survey in 77 tertiary hospitals in four Chinese cities.

scientific article

Novel frameshift mutation in the insulin (INS) gene in a family with maturity onset diabetes of the young (MODY)

scientific article published on 17 October 2018

Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

scientific article published on 4 June 2017

Obesity Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1α Transcriptional Network

scientific article published on 02 October 2018

Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population

scientific article

Observational Registry of Basal Insulin Treatment (ORBIT) in Patients with Type 2 Diabetes Uncontrolled by Oral Hypoglycemic Agents in China--Study Design and Baseline Characteristics.

scientific article published on 14 July 2015

Observational Registry of Basal Insulin Treatment (ORBIT) in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs: Real-life use of basal insulin in China

scientific article published on 17 March 2017

Observational study evaluating the effectiveness of physician-targeted education for improving glycemic management of patients with type 2 diabetes (BEYOND II)

scientific article published on 06 August 2019

Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes.

scientific article published in December 2004

Oviduct infection and hydrosalpinx in DBA1/j mice is induced by intracervical but not intravaginal inoculation with Chlamydia muridarum

scientific article

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration.

scientific article published on 2 November 2017

Past, present and future of latent autoimmune diabetes in adults

scientific article published on 31 July 2019

Pathophysiological characteristics in patients with latent autoimmune diabetes in adults using clamp tests: evidence of a continuous disease spectrum of diabetes

scientific article published on 01 August 2019

Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up.

scientific article published on 20 January 2016

Prevalence and associated factors of microalbuminuria in Chinese individuals without diabetes: cross-sectional study.

scientific article

Prevalence of cardiovascular disease and risk factors in the Chinese population with impaired glucose regulation: the 2007-2008 China national diabetes and metabolic disorders study.

scientific article published on 24 April 2013

Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc.

scientific article published on 4 July 2017

Protective effects of 1-alpha-hydroxyvitamin D3 on residual beta-cell function in patients with adult-onset latent autoimmune diabetes (LADA).

scientific article published in July 2009

Quantitation of L-arginine and asymmetric dimethylarginine in human plasma by LC-selective ion mode-MS for Type 2 diabetes mellitus study

scientific article published on 01 January 2011

Rap1 ameliorates renal tubular injury in diabetic nephropathy

scientific article published on 18 December 2013

Response to comment on Liu et al. Latent autoimmune diabetes in adults with low-titer GAD antibodies: similar disease progression with type 2 diabetes: a nationwide, multicenter prospective study (LADA China Study 3). Diabetes Care 2015;38:16-21

scientific article published on 01 March 2015

Revisiting multiple models of progression of β-cell loss of function in type 1 diabetes: Significance for prevention and cure

scientific article

Rosiglitazone preserves islet beta-cell function of adult-onset latent autoimmune diabetes in 3 years follow-up study.

scientific article

STAT3-mediated epigenetic silencing of FOXP3 in LADA T cells is regulated through HDAC5 and DNMT1.

scientific article published on 6 December 2017

Severe insulin resistance due to insulin antibodies

scientific article published on 06 April 2018

Standards of care for type 2 diabetes in China.

scientific article published on July 2016

Sumoylation Modulates the Susceptibility to Type 1 Diabetes.

scientific article published on January 2017

Tetraspanin 7 autoantibodies predict progressive decline of beta cell function in individuals with LADA

scientific article published on 29 December 2018

The CD4(+) regulatory T-cells is decreased in adults with latent autoimmune diabetes

scientific article published on 26 September 2006

The Imbalance of B-Lymphocyte Subsets in Subjects with Different Glucose Tolerance: Relationship with Metabolic Parameter and Disease Status

scientific article

The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis

scientific article

The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults

article

The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

scientific article

The clinical application of linagliptin in Asians

scientific article

The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese.

scientific article

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.

scientific article published on 21 December 2016

The new insights from DPP-4 inhibitors: their potential immune modulatory function in autoimmune diabetes

scientific article published on 01 November 2014

The potential application of Cordyceps in metabolic-related disorders

scientific article published on 31 October 2019

The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno-metabolic mechanisms

scientific article published on 13 August 2019

Therapeutic potential of umbilical cord blood cells for type 1 diabetes mellitus.

scientific article published on 20 March 2015

Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells

scientific article

Type 1 diabetes mellitus care and education in China: The 3C study of coverage, cost, and care in Beijing and Shantou.

scientific article published on 28 February 2017

Ultrasensitive detection of single nucleotide polymorphism in human mitochondrial DNA utilizing ion-mediated cascade surface-enhanced Raman spectroscopy amplification

scientific article published on 9 February 2015

Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L ⬇️

scientific article published on October 27, 2010

Use, Perspectives, and Attitudes Regarding Diabetes Management Mobile Apps Among Diabetes Patients and Diabetologists in China: National Web-Based Survey

article

Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Study

scientific article published on 10 November 2020

Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4(+) T cells that prevent experimental autoimmune diabetes

scientific article

Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model.

scientific article published on 8 November 2016

[Effect of cryopreservation method on islets specific T cell responses in type 1 diabetic patient]

scientific article published on 01 February 2013

[Precision medicine in type 1 diabetes: how far from where we stand?]

scientific article published on 01 January 2016

miR-101a and miR-30b contribute to inflammatory cytokine-mediated β-cell dysfunction

scientific article published on 14 September 2015

miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes

scientific article

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