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List of works by Kornélia Polyák

A confetti trail of tumour evolution

scientific article published on 01 June 2018

A neural survival factor is a candidate oncogene in breast cancer

scientific article

A putative role for psoriasin in breast tumor progression

scientific article

Abstract PR05: The effect of chemotherapy on HER2+ breast cancer heterogeneity measured by STAR-FISH: Detection of PIK3CA mutation and HER2 amplification at single-cell level in situ

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer

scientific article published on 11 May 2020

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

scientific article

Altered antisense-to-sense transcript ratios in breast cancer ⬇️

scientific article published on November 22, 2010

An anatomy of normal and malignant gene expression

scientific article

An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ

scientific article

BRCA1 haploinsufficiency for replication stress suppression in primary cells

scientific article

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells

scientific article published on 29 June 2016

Breast tumor heterogeneity: cancer stem cells or clonal evolution?

scientific article published on 17 August 2007

Breast-cancer stromal cells with TP53 mutations.

scientific article

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer

scientific article

Cancer Cell Phenotypes, in Fifty Shades of Grey ⬇️

scientific article published on 01 February 2013

Cell type-specific DNA methylation patterns in the human breast

scholarly article

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.

scientific article

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

scientific article

Cellular and molecular targets of estrogen in normal human breast tissue

scientific article published on 01 August 2002

Cellular heterogeneity and molecular evolution in cancer ⬇️

scientific article published on October 22, 2012

Classifying the evolutionary and ecological features of neoplasms

scientific article published on 15 September 2017

Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution

scientific article published on 25 August 2009

Clonal cooperation

scientific article published in Nature

Clonal evolution in cancer: a tale of twisted twines

scientific article

Co-evolution of tumor cells and their microenvironment

scientific article published on 04 December 2008

Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression

scientific article published on April 2006

Combining miR-10b-Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer.

scientific article

Contribution of bone marrow–derived endothelial cells to human tumor vasculature

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

scientific article

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples.

scientific article published in September 2010

Cyclooxygenase-2 expression during immortalization and breast cancer progression.

scientific article published on January 2008

DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma ⬇️

scientific article published on December 20, 2003

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

scientific article published on 20 March 2019

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling.

scientific article

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

scientific article published on 03 August 2016

Distinct epigenetic changes in the stromal cells of breast cancers

scientific article published on 10 July 2005

Do myoepithelial cells hold the key for breast tumor progression?

scientific article published on July 2005

EMSY links breast cancer gene 2 to the 'Royal Family'

scientific article

EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

scientific article published on 25 June 2019

Early-Life Body Adiposity and the Breast Tumor Transcriptome

scientific article published on 02 November 2020

Epidemiology, Biology, Treatment, and Prevention of Ductal Carcinoma In Situ (DCIS)

scholarly article published November 2018

Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium ⬇️

scientific article published on April 21, 2011

Epigenetic patterns of embryonic and adult stem cells

scientific article published on 26 March 2009

Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression

scientific article published on September 2008

Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women

scientific article published in March 2004

Evolutionary Pathways in BRCA1-Associated Breast Tumors ⬇️

scientific article published on April 10, 2012

Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer

scientific article published on 26 October 2016

Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues

scientific article (publication date: June 2002)

Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types

scientific article

Functional Synergies yet Distinct Modulators Affected by Genetic Alterations in Common Human Cancers

scientific article published on 11 March 2011

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells

scientific article published on 13 February 2017

Gene expression profiling of human breast tissue samples using SAGE-Seq

scientific article

Genetic and phenotypic diversity in breast tumor metastases

scientific article published on 21 January 2014

Genome-wide functional synergy between amplified and mutated genes in human breast cancer

scientific article

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

scientific article published on 03 October 2013

HIN-1, an inhibitor of cell growth, invasion, and AKT activation

scientific article

HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance

scientific article

Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.

scientific article

Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies

scientific article

Identifying tumor origin using a gene expression-based classification map.

scientific article

Immune Escape during Breast Tumor Progression

scientific article published on 01 April 2020

Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

scientific article published on 26 June 2017

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer

scientific article

Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition

scientific article published on 17 June 2020

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity

scientific article published on 23 January 2014

Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment

scientific article published on 24 January 2019

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

scientific article

Intra-tumor heterogeneity defines treatment-resistant HER2+ breast tumors

Intratumor Heterogeneity in Breast Cancer

scientific article published on January 2016

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

scientific article published on 01 April 2020

Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors

scholarly article by Inga H Rye et al published November 2018 in Molecular Oncology

Intratumoral Heterogeneity: More Than Just Mutations

scientific article published on 12 April 2019

JARID1B is a luminal lineage-driving oncogene in breast cancer

scientific article

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

scientific article

Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.

scientific article

MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis

scientific article published on 16 October 2014

Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk

scientific article published on 30 March 2017

Methylation-specific digital karyotyping

scientific article

Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis

scientific article published on 8 July 2013

Molecular characterization of the tumor microenvironment in breast cancer

scientific article

Molecular definition of breast tumor heterogeneity

scientific article

Molecular markers in ductal carcinoma in situ of the breast.

scientific article

Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.

scientific article published on 13 June 2013

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion

scientific article

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

scientific article published on 13 April 2008

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

scientific article

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

scientific article

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

scientific article

Oncogene-like induction of cellular invasion from centrosome amplification

scientific article

Origin of carcinoma associated fibroblasts

scientific article published on 19 February 2009

PIK3CA mutations in in situ and invasive breast carcinomas

scientific article

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival ⬇️

scientific article published on July 23, 2010

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

scientific article published on 13 September 2019

Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer.

scientific article

Precancer Atlas to Drive Precision Prevention Trials.

scientific article

Premenopausal plasma osteoprotegerin and breast cancer risk: a case-control analysis nested within the Nurses' Health Study II

scientific article published on 10 April 2020

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.

scientific article published on 29 September 2015

Profiling critical cancer gene mutations in clinical tumor samples

scientific article

Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants

scientific article

Psoriasin expression in mammary epithelial cells in vitro and in vivo ⬇️

scientific article published on January 1, 2002

Regulation of in situ to invasive breast carcinoma transition

scientific article published on May 2008

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

scientific article published on 6 January 2016

Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast

scholarly article

Roots and stems: stem cells in cancer

scientific article

SAGE and related approaches for cancer target identification

scientific article

Sequence analysis of mutations and translocations across breast cancer subtypes

scientific article

Serial analysis of gene expression

scientific article

Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.

scientific article published on 27 October 2008

Somatic mutations in the notch, NF‐KB, PIK3CA, and hedgehog pathways in human breast cancers ⬇️

scientific article published on February 3, 2012

Sorting out the FACS: a devil in the details

scientific article published on 01 March 2014

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

scientific article published on 26 September 2016

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

scientific article published on 01 July 2019

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

scientific article published on 07 May 2020

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

scientific article published on 01 October 2018

Targeting Akt3 signaling in triple-negative breast cancer.

scientific article published on 12 December 2013

Targeting the missing links for cancer therapy ⬇️

scientific article published on 01 March 2011

The Expression of Psoriasin (S100A7) and CD24 Is Linked and Related to the Differentiation of Mammary Epithelial Cells ⬇️

scientific article published on December 27, 2012

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors ⬇️

scientific article published on July 1, 2011

The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women

scientific article published on 03 March 2016

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor

scientific article published on September 2013

The cancer stem cell hypothesis: in search of definitions, markers, and relevance

scientific article published on 31 March 2008

The epithelial-mesenchymal transition generates cells with properties of stem cells

scientific article

The genomic landscapes of human breast and colorectal cancers

scientific article

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival

scientific article published on 7 June 2017

The microenvironment in breast cancer progression: biology and implications for treatment ⬇️

scientific article published on January 1, 2011

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium

scientific article published on 16 December 2011

Toward understanding and exploiting tumor heterogeneity

scientific article

Tracking tumor resistance using 'liquid biopsies'.

scientific article published in June 2013

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

scientific article (publication date: April 2009)

Tumor Neoantigens: When Too Much of a Good Thing Is Bad

scientific article published on 01 November 2019

Tumor heterogeneity: causes and consequences

scientific article

Tumor heterogeneity: the Lernaean hydra of oncology?

scientific article published on 01 September 2014

Tumorigenesis: it takes a village

scientific article published on 02 July 2015

Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung

scientific article published on May 2004

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