List of works - Erik Procko

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

scientific article

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.

scientific article published on 24 May 2016

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

scientific article published on 21 December 2020

Antigen processing and presentation: TAPping into ABC transporters

scientific article published on February 2009

Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene.

scientific article

Computational Design of a Protein-Based Enzyme Inhibitor

scientific article

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

scientific article

Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States

scientific article published on 15 May 2019

Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex

scientific article

Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community

scientific article published on 21 October 2020

Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

scientific article

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter

scientific journal article

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

scientific article published on 19 January 2022

Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology

scientific article published on 19 June 2020

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

scientific article published on 04 August 2020

Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter

scientific article published on 2 May 2008

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

scientific article published on October 2005

Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy

scientific article published on 16 March 2020

Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.

scientific article published in May 2007

Intracellular delivery system for antibody-Peptide drug conjugates

scientific article published on 11 February 2015

Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

scientific article published on 20 April 2018

Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection

scientific article published on 03 December 2019

Motif-Driven Design of Protein-Protein Interfaces

scientific article published in January 2016

Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants

scientific article published on 16 March 2021

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel ⬇️

scientific article published on July 25, 2012

Structural and energetic basis of folded-protein transport by the FimD usher

scientific article

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

scientific article published on 05 February 2019

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity

scientific article

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.

scientific article published on 27 January 2009

List of works by Erik Procko

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.

An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Antigen processing and presentation: TAPping into ABC transporters

Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene.

Computational Design of a Protein-Based Enzyme Inhibitor

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States

Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex

Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community

Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy

Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.

Intracellular delivery system for antibody-Peptide drug conjugates

Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection

Motif-Driven Design of Protein-Protein Interfaces

Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel ⬇️

Structural and energetic basis of folded-protein transport by the FimD usher

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.