List of works - Tony Bruns

A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of Activation

scientific article published on 24 May 2021

A Prospective Multicentre Study of the Epidemiology and Outcomes of Bloodstream Infection in Cirrhotic Patients

scientific article

A confocal view of the intestinal microcirculation in a patient with Crohn disease and portal vein thrombosis

scientific article published on 18 March 2011

Abnormal glucose tolerance: a predictor of 30-day mortality in patients with decompensated liver cirrhosis ⬇️

scientific article published on March 9, 2011

Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver

scientific article published on 27 September 2017

Acute Hepatitis E is an Underreported Cause of Severe Acute Liver Injury

scientific article published on 01 April 2019

Acute-on-Chronic Liver Failure

scientific article published on 12 July 2018

Acute-on-chronic liver failure - new Definition of a complex clinical picture

scientific article published on 2 June 2016

Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis--where do we stand?

scientific article

Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes

scientific article published on 27 February 2013

Autoimmune hepatitis in an HIV-infected patient: an intriguing association

scientific article published on 01 June 2012

Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver.

scientific article published on 16 October 2015

Blood group B is associated with azathioprine-induced acute pancreatitis in patients with IBD

scientific article published on 14 November 2016

CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation.

scientific article published on 12 March 2015

Calcineurin inhibitors or anti-TNF-α agents in severe ulcerative colitis: available options and limitations

scientific article published in April 2012

Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

scientific article published on 30 November 2018

Cholestatic hepatitis, acute acalculous cholecystitis, and hemolytic anemia: primary Epstein-Barr virus infection under azathioprine.

scientific article published in November 2009

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction

article published in 2021

Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure

scientific article

Drug monitoring in inflammatory bowel disease: helpful or dispensable?

scientific article published on 24 September 2009

Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study

scientific article

Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis

scientific article published on 04 January 2019

Effects of Antibiotics on Gut Microbiota.

scientific article

Emergence of spontaneous bacterial peritonitis due to enterococci - risk factors and outcome in a 12-year retrospective study.

scientific article

Empirical antibiotic therapy in intra-abdomial infections: cases and evidence-based therapeutic recommendations

scientific article published on 10 September 2013

Etiologies and outcomes of acute liver failure in Germany.

scientific article published on 25 February 2012

Extended Infusion of β-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis: An Observational Multicenter Study

scientific article published in 2019

External ventricular drain infections: risk factors and outcome.

scientific article published on 17 November 2014

Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis

scientific article published on 13 August 2019

Fungal Infections in Patients With Infected Pancreatic Necrosis and Pseudocysts: Risk Factors and Outcome.

scientific article

Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis

article

Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis

scientific article published on 31 July 2019

Guidelines for the Quantification of HIV and HCV in Small Volume Whole Blood Samples ⬇️

scientific article published on January 1, 2012

Hepatocellular carcinoma surveillance in hepatitis B virus-infected individuals: Who and how?

scientific article published on 4 June 2015

Homozygous carrier of the NOD2 1007fs frame-shift mutation presenting with refractory community-acquired spontaneous bacterial peritonitis and developing fatal pulmonary mucormycosis: A case report.

scientific article published in October 2011

Identification of bacterial DNA in neutrocytic and non-neutrocytic cirrhotic ascites by means of a multiplex polymerase chain reaction.

scientific article

Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.

scientific article published on 24 July 2017

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

scientific article published in Nature

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity

scientific article published on 9 February 2016

Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype?

scientific article published on 01 April 2018

Letter: serum vitamin D levels in primary biliary cirrhosis.

scientific article

Letter: the therapeutic potential of targeting CCL25/CCR9 in colonic inflammatory bowel disease - reading between the lines

scientific article published in August 2016

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis

scientific article published on 12 April 2014

Low ascitic fluid protein does not indicate an increased risk for spontaneous bacterial peritonitis in current cohorts

scientific article published on 24 May 2015

Low circulating chemerin levels correlate with hepatic dysfunction and increased mortality in decompensated liver cirrhosis.

scientific article published on 18 June 2018

Low serum transferrin correlates with acute-on-chronic organ failure and indicates short-term mortality in decompensated cirrhosis

scientific article published on 30 July 2016

Major Hepatic Complications in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis: Risk Factors and Time Trends in Incidence and Outcome

scientific article published on 12 December 2017

Medical and surgical therapy of inflammatory bowel disease in the elderly - prospects and complications.

scientific article published on 25 March 2011

Microbial spectrum of intra-abdominal abscesses in perforating Crohn's disease: Results from a prospective German Registry.

scientific article published on 5 February 2018

Mid-regional pro-adrenomedullin (MR-proADM): An even better prognostic biomarker than C-reactive protein to predict short-term survival in patients with decompensated cirrhosis at risk of infection? ⬇️

scientific article published on August 11, 2012

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history.

scientific article

Mortality after urinary tract infections in patients with advanced cirrhosis – Relevance of acute kidney injury and comorbidities ⬇️

scientific article published on February 1, 2013

Motivation of patients with inflammatory bowel disease to participate in a clinical trial

scientific article published on 10 October 2016

NOD2 Risk Variants and Pathological Bacterial Translocation in Decompensated Cirrhosis.

scientific article

NOD2 gene variants are a risk factor for culture‐positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis ⬇️

scientific article published on June 13, 2011

Nonlinear Multimodal Imaging Characteristics of Early Septic Liver Injury in a Mouse Model of Peritonitis

scientific article published on 13 August 2019

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

scientific article

Primed circulating monocytes are a source of IL-1β in patients with cirrhosis and ascites

scientific article published on 22 June 2020

Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy

scientific article published on 11 June 2018

Recruitment mechanisms of primary and malignant B cells to the human liver

scientific article published in October 2012

Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report.

scientific article

Reply to: “AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary biliary cirrhosis”

scientific article published on 23 August 2014

Reticulocyte count and hemoglobin concentration predict survival in candidates for liver transplantation.

scientific article published on February 2014

Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis

scientific article

Risk factors and outcome of bacterial infections in cirrhosis

scientific article published on March 2014

Risk factors for QT interval prolongation owing to acute gastrointestinal haemorrhage in patients with cirrhosis.

scientific article published in November 2012

SARS-CoV-2 as an extrahepatic precipitator of acute-on-chronic liver failure

scientific article published on 21 May 2020

Serum metabolic signatures in patients with overt hepatic encephalopathy

scientific article

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

scientific article published on 17 February 2021

Short-Term Isocaloric Intake of a Fructose- but not Glucose-Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

scientific article published on 02 January 2019

Spontaneous and secondary bacterial peritonitis in cirrhotic patients with ascites

scientific article published on 5 December 2011

Subacute liver failure induced by adalimumab

scientific article published on 01 January 2011

The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis

scientific article published on 11 September 2019

The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.

scientific article

The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection

scientific article published on 17 March 2011

The detection of the cytomegalovirus DNA in the colonic mucosa of patients with ulcerative colitis is associated with increased long-term risk of proctocolectomy: results from an outpatient IBD clinic

scientific article published on 30 November 2018

Thumb sucking or nail biting in childhood and adolescence is associated with an increased risk of Crohn's disease: results from a large case-control study

scientific article published on 30 July 2020

Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines

scientific article published on 28 December 2019

Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner.

scientific article published on 20 April 2017

Vedolizumab provides clinical benefit over 1 year in patients with active inflammatory bowel disease - a prospective multicenter observational study.

scientific article published on 7 October 2016

[54-year-old male with hepatic cirrhosis and therapy-associated torsade de pointes tachycardia]

scientific article published on 01 April 2011

[Cut a long story too short: Challenges in clinical research]

scientific article published on 28 February 2012

List of works by Tony Bruns

A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of Activation

A Prospective Multicentre Study of the Epidemiology and Outcomes of Bloodstream Infection in Cirrhotic Patients

A confocal view of the intestinal microcirculation in a patient with Crohn disease and portal vein thrombosis

Abnormal glucose tolerance: a predictor of 30-day mortality in patients with decompensated liver cirrhosis ⬇️

Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver

Acute Hepatitis E is an Underreported Cause of Severe Acute Liver Injury

Acute-on-Chronic Liver Failure

Acute-on-chronic liver failure - new Definition of a complex clinical picture

Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis--where do we stand?

Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes

Autoimmune hepatitis in an HIV-infected patient: an intriguing association

Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver.

Blood group B is associated with azathioprine-induced acute pancreatitis in patients with IBD

CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation.

Calcineurin inhibitors or anti-TNF-α agents in severe ulcerative colitis: available options and limitations

Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

Cholestatic hepatitis, acute acalculous cholecystitis, and hemolytic anemia: primary Epstein-Barr virus infection under azathioprine.

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction

Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure

Drug monitoring in inflammatory bowel disease: helpful or dispensable?

Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study

Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis

Effects of Antibiotics on Gut Microbiota.

Emergence of spontaneous bacterial peritonitis due to enterococci - risk factors and outcome in a 12-year retrospective study.

Empirical antibiotic therapy in intra-abdomial infections: cases and evidence-based therapeutic recommendations

Etiologies and outcomes of acute liver failure in Germany.

Extended Infusion of β-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis: An Observational Multicenter Study

External ventricular drain infections: risk factors and outcome.

Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis

Fungal Infections in Patients With Infected Pancreatic Necrosis and Pseudocysts: Risk Factors and Outcome.

Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis

Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis

Guidelines for the Quantification of HIV and HCV in Small Volume Whole Blood Samples ⬇️

Hepatocellular carcinoma surveillance in hepatitis B virus-infected individuals: Who and how?

Homozygous carrier of the NOD2 1007fs frame-shift mutation presenting with refractory community-acquired spontaneous bacterial peritonitis and developing fatal pulmonary mucormycosis: A case report.

Identification of bacterial DNA in neutrocytic and non-neutrocytic cirrhotic ascites by means of a multiplex polymerase chain reaction.

Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity

Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype?

Letter: serum vitamin D levels in primary biliary cirrhosis.

Letter: the therapeutic potential of targeting CCL25/CCR9 in colonic inflammatory bowel disease - reading between the lines

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis

Low ascitic fluid protein does not indicate an increased risk for spontaneous bacterial peritonitis in current cohorts

Low circulating chemerin levels correlate with hepatic dysfunction and increased mortality in decompensated liver cirrhosis.

Low serum transferrin correlates with acute-on-chronic organ failure and indicates short-term mortality in decompensated cirrhosis

Major Hepatic Complications in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis: Risk Factors and Time Trends in Incidence and Outcome

Medical and surgical therapy of inflammatory bowel disease in the elderly - prospects and complications.

Microbial spectrum of intra-abdominal abscesses in perforating Crohn's disease: Results from a prospective German Registry.

Mid-regional pro-adrenomedullin (MR-proADM): An even better prognostic biomarker than C-reactive protein to predict short-term survival in patients with decompensated cirrhosis at risk of infection? ⬇️

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history.

Mortality after urinary tract infections in patients with advanced cirrhosis – Relevance of acute kidney injury and comorbidities ⬇️

Motivation of patients with inflammatory bowel disease to participate in a clinical trial

NOD2 Risk Variants and Pathological Bacterial Translocation in Decompensated Cirrhosis.

NOD2 gene variants are a risk factor for culture‐positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis ⬇️

Nonlinear Multimodal Imaging Characteristics of Early Septic Liver Injury in a Mouse Model of Peritonitis

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

Primed circulating monocytes are a source of IL-1β in patients with cirrhosis and ascites

Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy

Recruitment mechanisms of primary and malignant B cells to the human liver

Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report.

Reply to: “AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary biliary cirrhosis”

Reticulocyte count and hemoglobin concentration predict survival in candidates for liver transplantation.

Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis

Risk factors and outcome of bacterial infections in cirrhosis

Risk factors for QT interval prolongation owing to acute gastrointestinal haemorrhage in patients with cirrhosis.

SARS-CoV-2 as an extrahepatic precipitator of acute-on-chronic liver failure

Serum metabolic signatures in patients with overt hepatic encephalopathy

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

Short-Term Isocaloric Intake of a Fructose- but not Glucose-Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Spontaneous and secondary bacterial peritonitis in cirrhotic patients with ascites

Subacute liver failure induced by adalimumab

The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis

The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.

The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection

The detection of the cytomegalovirus DNA in the colonic mucosa of patients with ulcerative colitis is associated with increased long-term risk of proctocolectomy: results from an outpatient IBD clinic

Thumb sucking or nail biting in childhood and adolescence is associated with an increased risk of Crohn's disease: results from a large case-control study

Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines

Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner.