List of works - Peter J McHugh

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

scientific article

DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta

scientific article published on 16 February 2006

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

scientific article published on 5 October 2009

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

scientific article published on September 2005

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

scientific article published on September 2011

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

scientific article

DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase

scientific article published on March 2005

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study

article by Denis C Talbot et al published 15 December 2010 in Clinical Cancer Research

DNA interstrand cross-link repair in Saccharomyces cerevisiae.

scientific article published on 9 November 2006

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants

scientific article published on 19 November 2007

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

scientific article

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

scientific article published on 22 February 2011

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

scientific article

EXD2 promotes homologous recombination by facilitating DNA end resection

scientific journal article

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

scientific article published on 9 March 2017

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

scientific article

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast

scientific article

The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair

scientific article published on December 6, 2010

Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA

scientific article

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

scientific article

Sunlight-induced mutagenicity of a common sunscreen ingredient

scientific article

The SNM1/Pso2 family of ICL repair nucleases: from yeast to man.

scientific article published on July 2010

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

scientific article

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

scientific article

Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links

scientific article

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

scientific article published on 17 November 2015

Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures

scientific article

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

scientific article

A prototypical Fanconi anemia pathway in lower eukaryotes?

scientific article published on 16 August 2012

XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selection.

scientific article

DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.

scientific article published in October 2007

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

scientific article

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors

scientific article published on 22 December 2017

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

scientific article published on 28 April 2016

Characterization of DNA damage inflicted by free radicals from a mutagenic sunscreen ingredient and its location using an in vitro genetic reversion assay

scientific article published on 01 August 1997

Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove

scientific article published on 01 September 2000

Microhomologies are prevalent at Cas9-induced larger deletions

scientific article published on 01 August 2019

PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells

scientific article published on 01 February 2002

Mgm101: A double-duty Rad52-like protein.

scientific article

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

scientific article published on 30 September 2020

Quantitative analysis of survivin protein expression and its therapeutic depletion by an antisense oligonucleotide in human lung tumors.

scientific article published on 19 June 2012

Apollo: a healer of the genome?

scientific article published on 01 July 2009

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

scientific article published on 01 September 2019

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

XPF-ERCC1: Linchpin of DNA crosslink repair

scientific article published on 09 April 2020

List of works by Peter J McHugh

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study

DNA interstrand cross-link repair in Saccharomyces cerevisiae.

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

EXD2 promotes homologous recombination by facilitating DNA end resection

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast

The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair

Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

Sunlight-induced mutagenicity of a common sunscreen ingredient

The SNM1/Pso2 family of ICL repair nucleases: from yeast to man.

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

A prototypical Fanconi anemia pathway in lower eukaryotes?

XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selection.

DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Characterization of DNA damage inflicted by free radicals from a mutagenic sunscreen ingredient and its location using an in vitro genetic reversion assay

Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove

Microhomologies are prevalent at Cas9-induced larger deletions

PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells

Mgm101: A double-duty Rad52-like protein.

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Quantitative analysis of survivin protein expression and its therapeutic depletion by an antisense oligonucleotide in human lung tumors.

Apollo: a healer of the genome?

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

XPF-ERCC1: Linchpin of DNA crosslink repair

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition