Search filters

List of works by Marketa J Zvelebil

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

scientific article published on 22 August 2017

A detailed molecular model for human aromatase

scientific article published on 01 March 1993

A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.

scientific article published on 05 July 2012

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

scientific article

A model of directional selection applied to the evolution of drug resistance in HIV-1.

scientific article published in February 2007

A modified method for whole exome resequencing from minimal amounts of starting DNA

scientific article

A molecular model for the enzyme cytochrome P450(17 alpha), a major target for the chemotherapy of prostatic cancer.

scientific article

A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC

scientific article published on 01 February 1995

A predicted three-dimensional structure of human cytochrome P450: implications for substrate specificity

scientific article published on 01 February 1991

A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia

scientific article

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

article

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

scientific article published on 13 February 2001

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor

scientific article published on 11 February 2014

CYP3A variation, premenopausal estrone levels, and breast cancer risk

scientific article published on 3 April 2012

Chemical development of intracellular protein heterodimerizers

scientific article

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

scientific article

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

scientific article

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

scientific article

Cluster analysis of an extensive human breast cancer cell line protein expression map database

scientific article (publication date: February 2002)

Combinatorial use of mRNA and two-dimensional electrophoresis expression data to choose relevant features for mass spectrometric identification

scientific article

Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer

scientific article

Correction: A Modified Method for Whole Exome Resequencing from Minimal Amounts of Starting DNA.

scientific article published on 3 April 2012

Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.

scientific article published on January 2004

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

scientific article

Deriving a mutation index of carcinogenicity using protein structure and protein interfaces

scientific article (publication date: 2014)

Differential protein synthesis and expression levels in normal and neoplastic human prostate cells and their regulation by type I and II interferons.

scientific article

Differential proteome analysis of replicative senescence in rat embryo fibroblasts.

scientific article

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

scientific article published on 14 November 2018

Effect of aromatase inhibition on functional gene modules in estrogen receptor-positive breast cancer and their relationship with antiproliferative response

scientific article published on 14 March 2014

Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers

scientific article published on 18 March 2013

Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system

scientific article

Exploring the specificity of the PI3K family inhibitor LY294002.

scientific article published on May 2007

FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets

scientific article

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.

scientific article

Flavopiridol Hoechst AG.

scientific article

Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA.

scientific article

Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts

scientific article

GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors

scientific article published on 06 May 2013

Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

scientific article published on April 2007

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

scientific article

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

scientific article

Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

scientific article published on 11 April 2011

Genomic characterisation of acral melanoma cell lines

scientific article published on July 2012

Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer

scientific article

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

scientific article

Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

scientific article

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

scientific article published on 19 October 2008

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

scientific article

Identification of germline missense mutations and rare allelic variants in theATM gene in early-onset breast cancer

article

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin

scientific article published on 07 January 2009

Inactivation of effector caspases through nondegradative polyubiquitylation

scientific article

Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides

scientific article

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

scientific article

MoKCa database--mutations of kinases in cancer.

scientific article

Mouse mammary stem cells express prognostic markers for triple-negative breast cancer

scientific article

Neuregulin 3 and erbb signalling networks in embryonic mammary gland development.

scientific article published on 07 May 2013

Normalized mean glandular dose computation from mammography using GATE: a validation study.

scientific article published on 11 March 2013

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

scientific article published on 17 March 2009

Peptide-protein interactions: an overview.

scientific article published on August 1993

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

scientific article published in December 1997

Phosphoinositide 3-kinase signalling--which way to target?

scientific article

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

scientific article

Prediction and analysis of SH2 domain-phosphopeptide interactions

scientific article published on 01 June 1995

Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins.

scientific article

Prediction of protein secondary structure and active sites using the alignment of homologous sequences

scientific article

Prediction of protein structure from sequence

scientific article

Proteomics--IBC's fourth annual conference--revolutionary technologies for drug target and biomarker identification.

scientific article published in May 2001

ROCK: a breast cancer functional genomics resource.

scientific article

ROCK: a resource for integrative breast cancer data analysis.

scientific article published on 12 June 2013

Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog

scientific article

Resources for integrative systems biology: from data through databases to networks and dynamic system models

scientific article

SH2 domains in plants imply new signalling scenarios.

scientific article published in April 2004

Structural and functional diversity of phosphoinositide 3-kinases.

scientific article published on February 1996

Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia

scientific article published on 01 February 1995

The C-terminal SH3 domain of p67phox binds its natural ligand in a reverse orientation.

scientific article

The FLIGHT Drosophila RNAi database: 2010 update

scientific article

The application of 2D gel-based proteomics methods to the study of breast cancer.

scientific article

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

scientific article

The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis

scientific article published on 23 November 2011

Three-dimensional solution structure of the pleckstrin homology domain from dynamin

scientific article

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment

scientific article published on 11 August 2011

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

scientific article

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

scientific article published on May 2012

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

scientific article published on 26 April 2012

Whole genome sequencing of matched primary and metastatic acral melanomas

scientific article

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

scientific article

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

scientific article

p110δ, a novel phosphoinositide 3-kinase in leukocytes

scientific article

pSTIING: a 'systems' approach towards integrating signalling pathways, interaction and transcriptional regulatory networks in inflammation and cancer.

scientific article

Paulina is supported by:

About Paulina

Help