List of works - Daniel I Pérez

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

scientific article published in December 2018

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

scientific article published on 28 January 2012

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

scientific article published on 3 February 2012

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

scientific article

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

scientific article

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets

scientific article published on 9 January 2016

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

scientific article published on 30 August 2017

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

scientific article published on 01 December 2019

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

scientific article published on 27 July 2016

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

scientific article published on 16 March 2012

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

scientific article

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

scientific article published on 12 August 2015

GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?

scientific article published on October 2008

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment ⬇️

scientific article published on June 30, 2011

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

scientific article

In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.

scientific article

Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.

scientific article published on January 2013

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

scientific article published on 5 October 2012

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

scientific article published on 8 October 2014

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

scientific article

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

scientific article published on 25 March 2016

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

scientific article published on 31 January 2011

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

scientific article published on 9 April 2013

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

scientific article

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

scientific article (publication date: 2016)

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

scientific article published on 30 April 2016

The Potential Role of Glycogen Synthase Kinase 3 Inhibitors as Amyotrophic Lateral Sclerosis Pharmacological Therapy ⬇️

scientific article published on January 1, 2011

The first enantioselective synthesis of palinurin.

scientific article published on 5 May 2009

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

scientific article published on 22 December 2015

Visible light-driven and chloroperoxidase-catalyzed oxygenation reactions

scientific article published on 01 October 2009

List of works by Daniel I Pérez

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment ⬇️

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.

Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

The Potential Role of Glycogen Synthase Kinase 3 Inhibitors as Amyotrophic Lateral Sclerosis Pharmacological Therapy ⬇️

The first enantioselective synthesis of palinurin.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

Visible light-driven and chloroperoxidase-catalyzed oxygenation reactions