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List of works by Marina Botto

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo

scientific article

A novel mechanism for complement activation at the surface of B cells following antigen binding

scientific article

A study of HLA (Bg) on red cells and platelets by immunoblotting with monoclonal antibodies ⬇️

scientific article published on February 1, 1990

A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45.

scientific article published in January 1998

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

scientific article published in July 2004

Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice

scientific article published in June 2001

Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia

scientific article

Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-a potential biomarker of disease activity

scientific article published on 5 April 2017

An essential protective role of IL-10 in the immunological mechanism underlying resistance vs susceptibility to lupus induction by dendritic cells and dying cells ⬇️

scientific article published on July 4, 2011

Antibodies to human serum amyloid P component eliminate visceral amyloid deposits

scientific article

Available carbon source influences the resistance of Neisseria meningitidis against complement

scientific article

B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis

scientific article

Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes

scientific article published on August 1992

Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection

scientific article

Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59.

scientific article published on 10 July 2008

C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus

scientific article published on 15 January 2016

C1q as a unique player in angiogenesis with therapeutic implication in wound healing

scientific article published on 03 March 2014

C1q deficiency and autoimmunity: the effects of genetic background on disease expression

scientific article published in March 2002

C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice

scientific article published on August 2007

C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells.

scientific article

C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa ⬇️

scientific article published on August 24, 2011

C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment

scientific article

C1q knock-out mice for the study of complement deficiency in autoimmune disease

scientific article

C1q restrains autoimmunity and viral infection by regulating CD8+T cell metabolism

scientific article published in Science

C1q, autoimmunity and apoptosis

scientific article

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens

scientific article published on 13 January 2014

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis

scientific article published on 17 January 2015

CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice

scientific article published in September 2003

CD59a deficiency exacerbates ischemia-reperfusion injury in mice

scientific article

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

scientific article

CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia

scientific article

Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice

scientific article published in June 2004

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes

scientific article

Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system

scientific article

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor

scientific article published on 12 May 2017

Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells

scientific article published in January 2004

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

scientific article published on 26 February 2015

Complement C3 Exacerbates Imiquimod-Induced Skin Inflammation and Psoriasiform Dermatitis

scientific article

Complement C3 plays an essential role in the control of opportunistic fungal infections

scientific article published on 06 July 2009

Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody

scientific article

Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury

scientific article

Complement deficiencies in humans and animals: links to autoimmunity

scientific article published on August 2006

Complement deficiency and autoimmunity

scientific article published on April 1997

Complement facilitates early prion pathogenesis

scientific article published in April 2001

Complement in human diseases: Lessons from complement deficiencies

scientific article published on 28 May 2009

Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy

scientific article published on 3 February 2016

Continual low-level activation of the classical complement pathway

scientific article

Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence

scientific article published on 13 October 2016

Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article published on 03 September 2009

Dectin-1 is required for beta-glucan recognition and control of fungal infection

scientific article published on 10 December 2006

Dysregulation of adaptive immune responses in complement C3-deficient patients

scientific article published on 19 January 2015

EcoRI polymorphism in the human third complement component (C3) gene

scientific article published in May 1990

Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice

scientific article

Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase

scientific article published on 2 May 2009

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice

scientific article

Genomic organization of human complement component C3.

scientific article

HLA class I (Bg) antigens on red cells of SLE patients: a serological study with polyclonal and monoclonal antibodies

scientific article published on January 1989

HLA class I expression on erythrocytes and platelets from patients with systemic lupus erythematosus, rheumatoid arthritis and from normal subjects

scientific article published on May 1990

Hereditary deficiency of C3 in animals and humans

scientific article

IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut.

scientific article

Identification and characterization of a lupus suppressor 129 locus on chromosome 3.

scientific article published on 30 April 2010

Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus

scientific article published on 31 August 2006

Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article published on 20 July 2009

Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway

scientific article published on 9 June 2008

In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus

scientific article

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils

scientific article published on 2 March 2011

Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection

scientific article published on February 2002

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

scientific article published on January 2014

Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency

scientific article

Jaccoud's postrheumatic arthritis. A clinical case report

scientific article published on April 1, 1992

Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis

scientific article published on January 2010

Links between complement deficiency and apoptosis

scientific article

Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency

scientific article published on 26 November 2012

Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus

scientific article published on June 2006

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum

scientific article published on 26 November 2014

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance

scientific article

Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis

scientific article published in March 2004

Murine D17H6S45 (Rd) gene: polymorphism and overlap with complement factor B.

scientific article published in October 1997

New approaches to the treatment of dense deposit disease

scientific article published on 5 August 2007

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

scientific article

Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy

scientific article

Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells

scientific article

Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal

scientific article

Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice

scientific article published on July 2008

Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice

scientific article published in December 2004

Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex

scientific article

Roles for phagocytic cells and complement in controlling relapsing fever infection

scientific article

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae

scientific article

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

scientific article published on 18 June 2021

Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice

scientific article

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

scientific article

Systemic lupus erythematosus, complement deficiency, and apoptosis

scientific article

Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie

scientific article

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

scientific article published on 09 July 2020

The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

scientific article

The development of atypical hemolytic uremic syndrome depends on complement C5

scientific article

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues

scientific article published in July 2002

The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

scientific article

The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization

scientific article published on January 1996

The paradoxical roles of C1q and C3 in autoimmunity

scientific article published on 11 May 2015

The rate of loss of CR1 from ageing erythrocytes in vivo in normal subjects and SLE patients: no correlation with structural or numerical polymorphisms

scientific article published on April 1988

The regulation of the complement system: insights from genetically-engineered mice

scientific article

The role of complement in the development of systemic lupus erythematosus

scientific article published on January 2004

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

scientific article published on 12 June 2018

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes

scientific article

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

scientific article published on 04 June 2019

Type I interferons affect the metabolic fitness of CD8<sup>+</sup> T cells from patients with systemic lupus erythematosus

scientific article published on 31 March 2021

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