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List of works by Hiroshi Kimura

A chromatin integration labelling method enables epigenomic profiling with lower input

scientific article published on 10 December 2018

A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo

scientific article published on 03 July 2019

A live imaging system to analyze spatiotemporal dynamics of RNA polymerase II modification in Arabidopsis thaliana

scientific article published on 14 May 2021

A mosaic of old and young nucleoporins

scientific article published on 15 January 2019

A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos

scientific article published on 20 November 2019

CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

scientific article published on 13 July 2020

Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo.

scientific article published on 15 May 2013

Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input

scientific article published on 17 August 2020

Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry

scientific article published on 01 December 2021

Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.

scientific article

Cohesin and condensin extrude DNA loops in a cell-cycle dependent manner

scientific article published on 12 May 2020

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

scientific article published on 19 December 2019

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

scientific article published on 03 March 2020

Correction: Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly.

scientific article published on 6 September 2017

Corrigendum: Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin.

scientific article published on 13 July 2015

Crystal structure of the human centromeric nucleosome containing CENP-A

scientific article

Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions

scientific article published on 18 July 2019

Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies

scientific article

Early development of cloned bovine embryos produced from oocytes enucleated by fluorescence metaphase II imaging using a conventional halogen-lamp microscope.

scientific article published on April 2015

Effect of mycalolides isolated from a marine sponge Mycale aff. nullarosette on actin in living cells

scientific article published on 17 May 2019

Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging

scientific article

Evidence for divergence of DNA methylation maintenance and a conserved inhibitory mechanism from DNA demethylation in chickens and mammals

scientific article published on 08 February 2021

Fluorescence cell imaging and manipulation using conventional halogen lamp microscopy

scientific article (publication date: 2012)

Genetically encoded system to track histone modification in vivo

scientific article published on January 2013

Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

scientific article published on 17 June 2020

H3K9me3 maintenance on a Human Artificial Chromosome is required for segregation but not centromere epigenetic memory

scientific article published on 23 June 2020

H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2.

scientific article

H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing

scientific article published on 19 February 2021

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

scientific article published on 16 January 2018

HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity

HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity ⬇️

scientific article published on 12 August 2024

Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription

scientific article published on 11 January 2019

Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.

scientific article

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

scientific article published on 11 April 2018

Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis

scientific article published on 15 January 2016

Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis

scientific article published on 30 September 2019

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

scientific article

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

scientific article published on 19 April 2018

Histone modification dynamics as revealed by a multicolor immunofluorescence-based single-cell analysis

scientific article published on 23 June 2020

Histone modifications associated with cancer cell migration and invasion.

scientific article

Histone modifications for human epigenome analysis ⬇️

scientific article published on 06 June 2013

Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay

scientific article published on 01 July 2019

Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

scientific article published on August 2017

In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2 ⬇️

scientific article published on August 16, 2013

Incorporation and influence of Leishmania histone H3 in chromatin

scientific article published on 01 December 2019

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation

scientific article

Intrabody-based FRET probe to visualize endogenous histone acetylation

scientific article published on 15 July 2019

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

scientific article published on 06 August 2018

Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites

scientific article published on 03 April 2020

Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation

scientific article

Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene

scientific article published on 26 May 2021

Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity

scientific article

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

scientific article published on 19 December 2015

Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections

scientific article published on 01 November 2021

Modular Redesign of a Cationic Lytic Peptide To Promote the Endosomal Escape of Biomacromolecules

scientific article published on 30 August 2018

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.

scientific article

Nap1 regulates proper CENP-B binding to nucleosomes

scientific article published on 15 January 2013

Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro

scientific article published on 16 February 2008

POINT technology illuminates the processing of polymerase-associated intact nascent transcripts

scientific article published on 17 March 2021

Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas

scientific article published on 20 August 2019

Pericentric Heterochromatin Generated by HP1 Protein Interaction-defective Histone Methyltransferase Suv39h1 ⬇️

scientific article published on July 7, 2013

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

scientific article published on February 2012

Polycomb-dependent nucleolus localization of Jumonji/Jarid2 during Drosophila spermatogenesis.

scientific article

Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development

scientific article published on 17 January 2013

Preparation of single-chain Fv antibodies in the cytoplasm of Escherichia coli by simplified and systematic chaperone optimization

scientific article published on 01 December 2019

RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells

scientific article published on 19 March 2021

Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans

scientific article

Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathway

scientific article published on 12 October 2019

Regulation of RNA polymerase II activation by histone acetylation in single living cells.

scientific article published on 21 September 2014

SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.

scientific article published on 23 March 2015

Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi

scientific article published on 13 December 2017

Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II

scientific article published on 01 March 2019

Single-molecule imaging reveals control of parental histone recycling by free histones during DNA replication

scientific article published on 18 September 2020

Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis

scientific article published on 02 December 2021

Specialized transcription factories within mammalian nuclei.

scientific article

Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin

scientific article

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T

scientific article

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2

scientific article

Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo

scientific article published on 08 June 2019

Structures of human nucleosomes containing major histone H3 variants

scientific article

Subnuclear gene positioning through lamina association affects copper tolerance

scientific article published on 20 November 2020

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

scientific article published in Nature Communications

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

scientific article published on 01 October 2019

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal

scientific article published on 08 March 2021

Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling

scientific article

Transcription organizes euchromatin similar to an active microemulsion

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

scientific article published on 27 November 2020

Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription

scientific article

Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase

scientific article

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

scientific article published on 20 September 2021

Visualizing posttranslational and epigenetic modifications of endogenous proteins in vivo

scientific article

Visualizing the Dynamics of Inactive X Chromosomes in Living Cells Using Antibody-Based Fluorescent Probes

scientific article published on 01 January 2018

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