List of works - Victor Tybulewicz

-specific atypical memory B cells are short-lived activated B cells

scientific article published on 02 November 2018

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

scientific article published on 01 October 1997

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

scientific journal article

A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.

scientific article

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

article

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

scientific article

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

scientific article

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

scientific journal article

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

scientific article

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome

scientific article

An Unexpected Role for IL-3 in the Embryonic Development of Hematopoietic Stem Cells

scientific article published on 01 August 2006

An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

scientific article

Analysis of antigen receptor signalling using mouse gene targeting ⬇️

scientific article published on April 1, 1998

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

scientific article

Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

scientific article

Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

scientific article (publication date: 5 April 2002)

Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion

scientific article published on 27 January 2014

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival

scientific article published on 18 May 2015

BLOOD-LYMPHATIC VESSEL INTEGRITY REQUIRES SYK TYROSINE KINASE SIGNALING WITHIN THE ENDOTHELIAL CELL COMPARTMENT

Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination

scientific article (publication date: 18 June 2007)

CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

scientific article published in May 1998

CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

scientific article published on 02 December 2007

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

scientific article

Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.

scientific article

Chemokines and the immunological synapse.

scientific article

Commentary: New insights into the complexity of phosphatidylinositol lipid signaling in B lymphocytes.

scientific article published in November 2004

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

scientific article published on 06 September 2021

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

scientific article published on 01 October 2000

Correction: Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

scientific article published on 14 July 2020

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

article

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

scientific article published on 14 October 2020

Critical structural role for the PH and C1 domains of the Vav1 exchange factor

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

scientific article

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas

scientific article published on 01 November 2007

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

scientific article published on 10 August 2004

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

scientific article published on 24 August 2009

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

article

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

scientific article

Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

scientific article published on 01 February 1999

Die regulatorische Funktion von VAV-1 in der chronischen Kolitis und im Kolitis-assozierten kolorektalem Karzinom

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

scientific article published on 2 December 2004

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

scientific article

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus

scientific article published on 13 May 2019

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

scientific article published on 01 February 2004

Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent

scientific article

Essential role of Rac1 and Rac3 GTPases in neuronal development

scientific article published on 06 January 2009

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

scientific article published on October 2016

Faculty of 1000 evaluation for Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

scientific article

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

scientific article

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

scientific article

Gene expression dysregulation domains are not a specific feature of Down syndrome

scientific article published on 06 June 2019

Generation of a panel of antibodies against proteins encoded on human chromosome 21.

scientific article

Genes for bacterial and mitochondrial ATP synthase

article

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

scientific article published on 14 January 2016

Grey Matter Sublayer Thickness Estimation in the Mouse Cerebellum

article by Ma Da et al published 2015 in Lecture Notes in Computer Science

HYPOPERFUSION IN THE ABSENCE OF APP GENE TRIPLICATION IN THE TC1 MOUSE MODEL OF DOWN’S SYNDROME

article

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

scientific article published in October 1998

Highly polymorphic sequence at D21S1448 mapping close to D21S55, within the Down syndrome critical region

scientific article published on 01 June 1995

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

scientific article

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen

scientific article

Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide

scientific article published in December 2002

Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide

scholarly article by Lesley A. Smyth et al published December 2002 in European Journal of Immunology

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

scientific journal article

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

scientific article

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

scientific article published in September 2005

Long noncoding RNAs in B-cell development and activation

scientific article published on 05 July 2016

Lymphocyte signaling: beyond knockouts.

scientific article published on 19 March 2009

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

scientific article published on 08 June 2021

Mechanism and function of Vav1 localisation in TCR signalling.

scientific article published on 6 September 2012

Mouse models of aneuploidy.

scientific article published on 3 January 2012

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

scientific article published on 11 May 2003

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

scientific journal article

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

scientific article

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

scientific article published on 3 November 2013

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation

scientific article

Rac GTPases play critical roles in early T-cell development

scientific article published on 16 December 2008

Rac1 and Rac2 regulate macrophage morphology but are not essential for migration

scientific article published on 13 June 2006

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

scientific article

Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration

scientific article published in March 2004

Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.

scientific article

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

scientific article

Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen

article

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

scientific article

Regulation of lymphatic-blood vessel separation by endothelial Rac1.

scientific article published on December 2009

Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

scientific article

Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell Priming

scientific article published in Science

Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin

scientific article

Rho family GTPases and their regulators in lymphocytes.

scientific article published on 21 August 2009

Rodent models in Down syndrome research: impact and future opportunities.

scientific article

STRUCTURE AND ASSEMBLY OF F1Fo ATPASE COMPLEX

Signalling through the TCR

scientific article published on 01 November 1998

Species-specific pace of development is associated with differences in protein stability

scientific article

Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.

scientific article published in September 2006

Syk is required for integrin signaling in neutrophils

scientific article published in April 2002

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.

scientific article published on February 2008

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

scientific article

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival

scientific article published on 10 April 2015

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

scientific journal article

Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

article by Salomé LeibundGut-Landmann et al published 22 April 2007 in Nature Immunology

Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan

scientific article published on June 2007

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

scientific journal article

T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue

scientific article

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

scientific article

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

scientific article published on 28 February 2013

The importance of understanding individual differences in Down syndrome

scientific article

The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.

scientific article published in April 2004

Themis2 is not required for B cell development, activation, and antibody responses.

scientific article

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation ⬇️

scientific article published on December 1, 1997

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

scientific article (publication date: March 2000)

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

scientific article published in April 2003

Using primary neurons from transgenic mice to identify genes on human chromosome 21 influencing Alzheimer's neuropathology

article

Vav1 GEF activity is required for T cell mediated allograft rejection

scientific article

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

scientific article published in Journal of Biological Chemistry

Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization

scientific article published on 31 August 2005

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

scientific article

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

scientific article

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

scientific article published on 01 March 2003

Vav3 regulates osteoclast function and bone mass

scientific article published on 13 February 2005

WNK1 kinase balances T cell adhesion versus migration in vivo

scientific article

[18] DNA sequence and transcription of genes for ATP synthase subunits from photosynthetic bacteria

article

List of works by Victor Tybulewicz

-specific atypical memory B cells are short-lived activated B cells

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome

An Unexpected Role for IL-3 in the Embryonic Development of Hematopoietic Stem Cells

An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

Analysis of antigen receptor signalling using mouse gene targeting ⬇️

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival

BLOOD-LYMPHATIC VESSEL INTEGRITY REQUIRES SYK TYROSINE KINASE SIGNALING WITHIN THE ENDOTHELIAL CELL COMPARTMENT

Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination

CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.

Chemokines and the immunological synapse.

Commentary: New insights into the complexity of phosphatidylinositol lipid signaling in B lymphocytes.

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

Correction: Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

Critical structural role for the PH and C1 domains of the Vav1 exchange factor

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

Die regulatorische Funktion von VAV-1 in der chronischen Kolitis und im Kolitis-assozierten kolorektalem Karzinom

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent

Essential role of Rac1 and Rac3 GTPases in neuronal development

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Faculty of 1000 evaluation for Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Gene expression dysregulation domains are not a specific feature of Down syndrome

Generation of a panel of antibodies against proteins encoded on human chromosome 21.

Genes for bacterial and mitochondrial ATP synthase

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Grey Matter Sublayer Thickness Estimation in the Mouse Cerebellum

HYPOPERFUSION IN THE ABSENCE OF APP GENE TRIPLICATION IN THE TC1 MOUSE MODEL OF DOWN’S SYNDROME

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

Highly polymorphic sequence at D21S1448 mapping close to D21S55, within the Down syndrome critical region

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen

Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide

Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

Long noncoding RNAs in B-cell development and activation

Lymphocyte signaling: beyond knockouts.

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Mechanism and function of Vav1 localisation in TCR signalling.

Mouse models of aneuploidy.

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation

Rac GTPases play critical roles in early T-cell development

Rac1 and Rac2 regulate macrophage morphology but are not essential for migration

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.