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List of works by Ewan Pearson

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

scientific article published on 01 October 2019

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

scientific article published on 10 May 2017

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

scientific article published on 23 October 2018

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

scientific article

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

scientific article

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes

scientific article

Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study

scientific article published on 21 April 2017

Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study

scientific article published in April 2009

Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database.

scientific article published on 17 December 2015

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

scientific article published on 15 December 2014

Associations between parental type 2 diabetes risk and offspring birthweight and placental weight: a survival analysis using the Walker cohort

scientific article published in 2022

Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation

scientific article

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

scientific article

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

scientific article published on August 2017

CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes

scientific article published on 6 June 2016

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes.

scientific article published on 29 July 2017

Clarifying the relationship between metformin, acute kidney injury and lactic acidosis

scientific article

Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study

scientific article

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS).

scientific article published on 7 September 2017

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study

scientific article

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

scientific article

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells

scientific article published on July 2006

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations

scientific article published in May 2004

Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations

scientific article published in February 2006

Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study

scientific article published on 6 September 2017

Crossover studies can help the individualisation of care in type 2 diabetes: the MASTERMIND approach

scholarly article published May 2016

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

scientific article published on 03 April 2020

Desktop software to identify patients eligible for recruitment into a clinical trial: using SARMA to recruit to the ROAD feasibility trial

scientific article published on 01 January 2010

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

scientific article published on 26 September 2019

Diabetes: Is There a Future for Pharmacogenomics Guided Treatment?

scientific article published on 01 August 2019

Differential Association of Genetic Risk of Coronary Artery Disease With Development of Heart Failure With Reduced Versus Preserved Ejection Fraction

scientific article published on 01 February 2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

scientific article published on 15 June 2019

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

scientific article

Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population

scientific article published on 01 December 2015

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

scientific article published on 10 August 2021

Drug-drug-gene interactions and adverse drug reactions

scientific article published on 03 December 2019

Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.

scientific article published on 4 August 2016

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis.

scientific article

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

scholarly article by Pamela Bowman et al published August 2018 in The Lancet: Diabetes & Endocrinology

Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

publication published on 01 August 2020

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach

Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.

scientific article published on 25 August 2017

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

scientific article published on 25 September 2018

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.

scientific article published on 19 February 2018

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes

scientific article published in August 2006

Generation, validation and humanisation of a novel insulin resistant cell model.

scientific article published on 23 June 2010

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

scientific article published on 26 April 2016

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes.

scientific article published on 12 April 2018

Genetic cause of hyperglycaemia and response to treatment in diabetes

scientific article (publication date: 18 October 2003)

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

scientific article published on 18 November 2009

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

scientific article published on 23 October 2018

Glycemic exposure and blood pressure influencing progression and remission of diabetic retinopathy: a longitudinal cohort study in GoDARTS.

scientific article published on 29 October 2013

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

scientific article

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

scientific article published in 2023

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

scientific article

Increased all-cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene

scientific article

Insights from genome-wide association studies of drug response

scientific article published on 16 October 2012

Insulin resistance before and after parathyroidectomy in patients with primary hyperparathyroidism--a pilot study

scientific article published in May 2010

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

scientific article published on 2 January 2018

Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia: A GoDARTS Study

scientific article

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes

scientific article published on 14 February 2012

Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.

scientific article published on 30 September 2009

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

scientific article published on 06 April 2018

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

scientific article

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

scientific article published on 21 September 2017

Metformin and the gastrointestinal tract

scientific article

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

scientific article published on 22 November 2019

Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4α mutations in a large European collection

article

Molecular mechanism of action of metformin: old or new insights?

scientific article

Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors

scientific article published on 17 December 2014

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

scientific article published on 30 January 2019

No deterioration in glycemic control in HNF-1alpha maturity-onset diabetes of the young following transfer from long-term insulin to sulphonylureas

scientific article published in November 2003

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis

scientific article

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

scientific article published on 10 October 2019

Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank

scientific article published on 28 July 2020

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes

scientific article

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

scientific article

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

scientific article published on 12 July 2018

Personalized medicine in diabetes: the role of 'omics' and biomarkers

scientific article

Pharmacogenetics in diabetes

scientific article published on April 2009

Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents

scientific article

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

scientific article published on 19 February 2018

Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients

scientific article published on 12 July 2017

Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

scientific article published on 01 July 2020

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy.

scientific article published on 31 January 2018

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

scientific article published on 19 June 2020

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study

scientific article

Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers

scientific article published on 9 January 2007

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

scientific article published on 15 December 2020

Quantifying the extent to which index event biases influence large genetic association studies

scientific article published on 30 December 2016

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies

scientific article published on 17 May 2018

RD Lawrence lecture 2013. Stratified approaches to the management of diabetes

scientific article published in April 2014

Rates of glycaemic deterioration in a real-world population with type 2 diabetes.

scientific article published on 19 December 2017

Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance

scientific article published on 25 November 2015

Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes

scientific article published on 16 May 2006

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study

scientific article published on 31 March 2009

Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?

scientific article published on 11 February 2019

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels

scientific article (publication date: December 2003)

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

scientific article

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study ⬇️

scientific article published on 10 June 2021

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).

scientific article published on 19 July 2017

Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design.

scientific article published on 15 July 2016

Response to Comment on Gan et al. Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2020;43:1948-1957

scientific article published on 01 December 2020

Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study

scientific article published on 14 August 2020

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with [...]

scientific article

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes

scientific article published on 01 July 2000

Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene.

scientific article

Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene

scientific article published on 01 December 2002

Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study

scientific article published on 28 September 2018

Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

scientific article

Statistical power considerations in genotype-based recall randomized controlled trials

scientific article

Strategies to identify individuals with monogenic diabetes: results of an economic evaluation

scientific article published on 18 March 2020

Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes.

scientific article published on 13 November 2016

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

scientific article published in August 2006

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.

scientific article published on 06 June 2016

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

scientific article published on 14 May 2013

The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study

scientific article

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study

scientific article published on 10 January 2019

The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes.

scientific article published in February 2006

The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

scholarly article by Harriet J A Teare et al published 4 September 2018 in Life sciences, society and policy

The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations

scientific article published on 10 January 2007

The role of ATM in response to metformin treatment and activation of AMPK.

scientific article

The search for predictive metabolic biomarkers for incident T2DM

scientific article published on 01 August 2018

The utility of retinal screening in gestational diabetes

scientific article

Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017

scientific article published on 04 April 2019

Transition from insulin to sulfonylurea in a child with diabetes due to a mutation in KCNJ11 encoding Kir6.2--initial and long-term response to sulfonylurea therapy

scientific article published on 12 June 2008

Translating TCF7L2: from gene to function

scientific article published on 22 April 2009

Treating type 2 diabetes in youth: a depressing picture ⬇️

scientific article published on 01 January 2012

Type 2 diabetes: a multifaceted disease.

scientific article published on 3 June 2019

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

scientific article

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

scientific article published on 22 May 2007

Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study

scientific article published on 18 March 2019

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

scientific article published on 08 August 2016

Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes

scientific article published on 14 November 2019

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

scientific article published on 08 November 2018

Zinc transport and diabetes risk

scientific article published on 01 April 2014

tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy

scientific article published on 3 November 2015

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