List of works - Ralph Mazitschek

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells

scientific article published on 3 August 2007

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

scientific article published on September 2010

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

scientific article (publication date: 2014)

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

scientific article published on 06 April 2020

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

scientific article

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

scientific article published on 19 August 2013

Antiplasmodial activity of piperazine sulfonamides

scientific article published on 31 October 2009

Bioorthogonal turn-on probes for imaging small molecules inside living cells

scientific article published on 19 March 2010

Characterization of Plasmodium Liver Stage Inhibition by Halofuginone ⬇️

scientific article published on March 21, 2012

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

scientific article

Chemical interrogation of the malaria kinome

scientific article

Chemical phylogenetics of histone deacetylases

scientific article

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

scientific article published on 23 March 2009

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

scientific article published on 13 March 2014

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

scientific article

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

scientific article published on 07 April 2008

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

scientific article

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

scientific article

Efficient acid-catalyzed (18) F/(19) F fluoride exchange of BODIPY dyes

scientific article

Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.

scientific article

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

scientific article published on 31 July 2015

Fluorescence anisotropy imaging in drug discovery

scientific article published in February 2018

Frontispiece: Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

article by Vunnam Srinivasulu et al published 12 October 2017 in Chemistry—A European Journal

HDAC2 negatively regulates memory formation and synaptic plasticity.

scientific article

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

scientific article

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

scientific article

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

scientific article

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

scientific article

High-throughput screen for novel antimicrobials using a whole animal infection model

scientific article published on July 2009

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

scientific article published on 15 August 2006

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

scientific article (publication date: 23 April 2009)

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

scientific article

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

scientific article

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

scientific article

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

scientific article published on February 2015

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks

scientific article

Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice.

scientific article

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity

scientific article

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging

scientific article published on 29 June 2017

Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

scientific article

Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker

scientific article

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

scientific article

On the inhibition of histone deacetylase 8

scientific article published on 3 April 2010

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

scientific article

Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents

scientific article

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation

scientific article published on 19 October 2012

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

scientific article

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model

scientific article published on 4 February 2014

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

scientific article published on 11 July 2017

Structural origin of selectivity in class II-selective histone deacetylase inhibitors

scientific article published on 16 April 2008

Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines

scientific article published on 31 October 2009

Synthesis and biological evaluation of Santacruzamate-A based analogues

scientific article

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

scientific article published on 22 April 2005

Synthesis and biological investigation of novel tricyclic benzodiazepinedione-based RGD analogues

scientific article published in November 2002

Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging

scientific article published on 4 April 2012

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling

scientific article published on 21 February 2019

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

scientific article

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

scientific article published in December 2002

Treatment of obesity with celastrol

scientific article published on May 2015

Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice

scientific article published on 28 February 2017

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis

scientific article published on 22 April 2009

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

scientific article

List of works by Ralph Mazitschek

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

Antiplasmodial activity of piperazine sulfonamides

Bioorthogonal turn-on probes for imaging small molecules inside living cells

Characterization of Plasmodium Liver Stage Inhibition by Halofuginone ⬇️

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Chemical interrogation of the malaria kinome

Chemical phylogenetics of histone deacetylases

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Efficient acid-catalyzed (18) F/(19) F fluoride exchange of BODIPY dyes

Expansion of the trans-Golgi network following activated collagen secretion is supported by a coiled-coil microtubule-bundling protein, p180, on the ER.

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Fluorescence anisotropy imaging in drug discovery

Frontispiece: Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

HDAC2 negatively regulates memory formation and synaptic plasticity.

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

High-throughput screen for novel antimicrobials using a whole animal infection model

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks

Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice.

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging

Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines

Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

On the inhibition of histone deacetylase 8

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Structural origin of selectivity in class II-selective histone deacetylase inhibitors

Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines

Synthesis and biological evaluation of Santacruzamate-A based analogues

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

Synthesis and biological investigation of novel tricyclic benzodiazepinedione-based RGD analogues

Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

Traceless solid-phase synthesis of 2-aminothiazoles: receptor tyrosine kinase inhibitors with dual selectivity for Tie-2 and VEGFR-2.

Treatment of obesity with celastrol

Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor