List of works - Chi Chen

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach

scientific article

A metabolomic perspective of melatonin metabolism in the mouse

scientific article published on 10 January 2008

Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies

scientific article published on 21 December 2017

Analysis of Gastrointestinal Responses Revealed Both Shared and Specific Targets of Zinc Oxide and Carbadox in Weaned Pigs

scientific article published on 30 July 2020

Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats

scientific article

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

scientific article published on 04 May 2006

Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling

scientific article published on 3 October 2012

Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota.

scientific article

Counteracting Roles of Lipidic Aldehydes and Phenolic Antioxidants on Soy Protein Oxidation Defined by a Chemometric Survey of Solvent and Mechanically Extracted Soybean Meals

scientific article published on 13 July 2023

Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems

scientific journal article

Dietary chemopreventive compounds and ARE/EpRE signaling.

scientific article published on June 2004

Dietary peroxidized maize oil affects the growth performance and antioxidant status of nursery pigs

scientific article published in June 2016

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

scientific article published in July 2007

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

scientific article published in March 2005

Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.

scientific article published on April 2003

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

scientific article published on 7 June 2013

Effect of feeding peroxidized dried distillers grains with solubles to sows and progeny on growth performance and metabolic oxidative status of nursery pigs.

scientific article published in January 2015

Effects of feeding diets containing highly peroxidized distillers dried grains with solubles and increasing vitamin E levels to wean-finish pigs on growth performance, carcass characteristics, and pork fat composition

scientific article published on 28 October 2013

Emerging applications of metabolomics in studying chemopreventive phytochemicals.

scientific article published on 22 June 2013

Enhanced Production of κ-Carrageenase and κ-Carrageenan Oligosaccharides through Immobilization of Thalassospira sp. Fjfst-332 with Magnetic Fe3O4-Chitosan Microspheres.

scientific article published on 16 August 2017

Evaluation of a partially de-oiled microalgae product in nursery pig diets

scientific article published on 13 April 2018

Evaluation of instrumental methods for the untargeted analysis of chemical stimuli of orange juice flavour

Experimental facility had a greater effect on growth performance, gut microbiome, and metabolome in weaned pigs than feeding diets containing subtherapeutic levels of antibiotics: A case study

scientific article published on 3 August 2023

Fecal Hyodeoxycholic Acid Is Correlated With Tylosin-Induced Microbiome Changes in Growing Pigs

scientific article published on 28 August 2018

Growing Chlorella sp. on meat processing wastewater for nutrient removal and biomass production

scientific article

Growth Performance, Metabolomics, and Microbiome Responses of Weaned Pigs Fed Diets Containing Growth-Promoting Antibiotics and Various Feed Additives

scientific article published on 23 December 2023

High sulfur content in corn dried distillers grains with solubles protects against oxidized lipids by increasing sulfur-containing antioxidants in nursery pigs.

scientific article published on 12 March 2013

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

scientific article published on 10 March 2008

Identification of Independent and Shared Metabolic Responses to High-Fiber and Antibiotic Treatments in Fecal Metabolome of Grow-Finish Pigs

scientific article published on 26 July 2022

Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis

scientific article published on 6 January 2012

Identification of Protective Amino Acid Metabolism Events in Nursery Pigs Fed Thermally Oxidized Corn Oil

scientific article published on 8 January 2023

Identification of Quinone Degradation as a Triggering Event for Intense Pulsed Light-Elicited Metabolic Changes in Escherichia coli by Metabolomic Fingerprinting

scientific article published in 2021

Identification of Sinapine-Derived Choline from a Rapeseed Diet as a Source of Serum Trimethylamine N-Oxide in Pigs

scientific article published on 25 June 2019

Identification of activation of tryptophan-NAD+ pathway as a prominent metabolic response to thermally oxidized oil through metabolomics-guided biochemical analysis

scientific article published on 25 April 2018

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

scientific article published on 19 November 2020

Identification of redox imbalance as a prominent metabolic response elicited by rapeseed feeding in swine metabolome.

scientific article

Identifying factors contributing to slow growth in pigs

scientific article published on May 2016

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

scientific article published on 26 February 2004

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

scientific article published in November 2004

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

scientific article

Influence of thermally oxidized vegetable oils and animal fats on energy and nutrient digestibility in young pigs

scientific article published on 30 May 2014

Influence of thermally oxidized vegetable oils and animal fats on growth performance, liver gene expression, and liver and serum cholesterol and triglycerides in young pigs

scientific article published on 30 May 2014

Influence of thermally oxidized vegetable oils and animal fats on intestinal barrier function and immune variables in young pigs

scientific article published on 30 May 2014

Inhibitory Effects of Green Tea Polyphenols on Microbial Metabolism of Aromatic Amino Acids in Humans Revealed by Metabolomic Analysis.

scientific article published on 11 May 2019

Kinetics of Forming Aldehydes in Frying Oils and Their Distribution in French Fries Revealed by LC-MS-Based Chemometrics

scientific article published on 09 May 2016

LC-MS-Based Metabolomic Investigation of Chemopreventive Phytochemical-Elicited Metabolic Events

scientific article published on January 2016

LC-MS-based Metabolomics of Xenobiotic-induced Toxicities.

scientific article published on 12 March 2013

LC-MS-based metabolomics in drug metabolism

scientific article

Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity.

scientific article

Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis

scientific article published on 19 February 2020

Mass isotopomer-guided decluttering of metabolomic data to visualize endogenous biomarkers of drug toxicity

scientific article published on 20 September 2018

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

scientific article published on October 2009

Metabolomic Profiling of Staphylococcus aureus

scientific article published on 01 January 2020

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

scientific article

Metabolomic investigation of methicillin-resistant Staphylococcus aureus

scientific article published in January 2014

Metabolomics revealed diurnal heat stress and zinc supplementation-induced changes in amino acid, lipid, and microbial metabolism.

scientific article published on January 2016

Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis

scientific article published on February 2008

Metabolomics: Bridging Chemistry and Biology in Drug Discovery and Development

scientific article published on 23 January 2017

Methods to create thermally oxidized lipids and comparison of analytical procedures to characterize peroxidation

scientific article published on 06 May 2014

Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection

scientific article

Mitigating ammonia nitrogen deficiency in dairy wastewaters for algae cultivation.

scientific article published on 19 November 2015

Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

scientific article published on August 2006

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.

scientific article

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

scientific article

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

scientific article published on 24 February 2016

Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention.

scientific article published on July 2013

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

scientific article published in December 2006

Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats

scientific article published on 06 June 2016

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis ⬇️

scientific article published on September 1, 2010

Purification and Characterisation of κ-Carrageenan Oligosaccharides Prepared by κ-Carrageenase from Thalassospira sp. Fjfst-332.

scientific article

Role of secretoglobin 3A2 in lung development.

scientific article

Serum metabolite markers of early Mycoplasma hyopneumoniae infection in pigs

scientific article published on 26 November 2019

Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.

scientific article

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

scientific article

Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

scientific article

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

scientific article

Toxicogenomics of resveratrol in rat liver.

scientific article published in April 2005

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.

scientific article published on 17 October 2015

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

scientific article published on 17 September 2005

List of works by Chi Chen

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach

A metabolomic perspective of melatonin metabolism in the mouse

Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies

Analysis of Gastrointestinal Responses Revealed Both Shared and Specific Targets of Zinc Oxide and Carbadox in Weaned Pigs

Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling

Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota.

Counteracting Roles of Lipidic Aldehydes and Phenolic Antioxidants on Soy Protein Oxidation Defined by a Chemometric Survey of Solvent and Mechanically Extracted Soybean Meals

Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems

Dietary chemopreventive compounds and ARE/EpRE signaling.

Dietary peroxidized maize oil affects the growth performance and antioxidant status of nursery pigs

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Effect of feeding peroxidized dried distillers grains with solubles to sows and progeny on growth performance and metabolic oxidative status of nursery pigs.

Effects of feeding diets containing highly peroxidized distillers dried grains with solubles and increasing vitamin E levels to wean-finish pigs on growth performance, carcass characteristics, and pork fat composition

Emerging applications of metabolomics in studying chemopreventive phytochemicals.

Enhanced Production of κ-Carrageenase and κ-Carrageenan Oligosaccharides through Immobilization of Thalassospira sp. Fjfst-332 with Magnetic Fe3O4-Chitosan Microspheres.

Evaluation of a partially de-oiled microalgae product in nursery pig diets

Evaluation of instrumental methods for the untargeted analysis of chemical stimuli of orange juice flavour

Experimental facility had a greater effect on growth performance, gut microbiome, and metabolome in weaned pigs than feeding diets containing subtherapeutic levels of antibiotics: A case study

Fecal Hyodeoxycholic Acid Is Correlated With Tylosin-Induced Microbiome Changes in Growing Pigs

Growing Chlorella sp. on meat processing wastewater for nutrient removal and biomass production

Growth Performance, Metabolomics, and Microbiome Responses of Weaned Pigs Fed Diets Containing Growth-Promoting Antibiotics and Various Feed Additives

High sulfur content in corn dried distillers grains with solubles protects against oxidized lipids by increasing sulfur-containing antioxidants in nursery pigs.

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

Identification of Independent and Shared Metabolic Responses to High-Fiber and Antibiotic Treatments in Fecal Metabolome of Grow-Finish Pigs

Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis

Identification of Protective Amino Acid Metabolism Events in Nursery Pigs Fed Thermally Oxidized Corn Oil

Identification of Quinone Degradation as a Triggering Event for Intense Pulsed Light-Elicited Metabolic Changes in Escherichia coli by Metabolomic Fingerprinting

Identification of Sinapine-Derived Choline from a Rapeseed Diet as a Source of Serum Trimethylamine N-Oxide in Pigs

Identification of activation of tryptophan-NAD+ pathway as a prominent metabolic response to thermally oxidized oil through metabolomics-guided biochemical analysis

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

Identification of redox imbalance as a prominent metabolic response elicited by rapeseed feeding in swine metabolome.

Identifying factors contributing to slow growth in pigs

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

Influence of thermally oxidized vegetable oils and animal fats on energy and nutrient digestibility in young pigs

Influence of thermally oxidized vegetable oils and animal fats on growth performance, liver gene expression, and liver and serum cholesterol and triglycerides in young pigs

Influence of thermally oxidized vegetable oils and animal fats on intestinal barrier function and immune variables in young pigs

Inhibitory Effects of Green Tea Polyphenols on Microbial Metabolism of Aromatic Amino Acids in Humans Revealed by Metabolomic Analysis.

Kinetics of Forming Aldehydes in Frying Oils and Their Distribution in French Fries Revealed by LC-MS-Based Chemometrics

LC-MS-Based Metabolomic Investigation of Chemopreventive Phytochemical-Elicited Metabolic Events

LC-MS-based Metabolomics of Xenobiotic-induced Toxicities.

LC-MS-based metabolomics in drug metabolism

Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity.

Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis

Mass isotopomer-guided decluttering of metabolomic data to visualize endogenous biomarkers of drug toxicity

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

Metabolomic Profiling of Staphylococcus aureus

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

Metabolomic investigation of methicillin-resistant Staphylococcus aureus

Metabolomics revealed diurnal heat stress and zinc supplementation-induced changes in amino acid, lipid, and microbial metabolism.

Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis

Metabolomics: Bridging Chemistry and Biology in Drug Discovery and Development

Methods to create thermally oxidized lipids and comparison of analytical procedures to characterize peroxidation

Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection

Mitigating ammonia nitrogen deficiency in dairy wastewaters for algae cultivation.

Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Pharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemoprevention.

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis ⬇️

Purification and Characterisation of κ-Carrageenan Oligosaccharides Prepared by κ-Carrageenase from Thalassospira sp. Fjfst-332.

Role of secretoglobin 3A2 in lung development.

Serum metabolite markers of early Mycoplasma hyopneumoniae infection in pigs

Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

Toxicogenomics of resveratrol in rat liver.

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.