List of works - Takahiro Kuchimaru

A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides

scientific article

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.

scientific article published on 14 June 2016

A metal carbonyl-protein needle composite designed for intracellular CO delivery to modulate NF-κB activity

scientific article published on 11 September 2015

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

scientific article published on 04 October 2016

A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries

scientific article published in Nature Communications

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.

scientific article

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia.

scientific article

Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation

scientific article published on 13 January 2015

Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use

scientific article published on 21 January 2020

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging

scientific article

Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release

scientific article published on 23 November 2016

Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model

scientific article published on 06 June 2016

In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system

scientific article

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe

scientific article

Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes

scientific article

Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress

scientific article published on 01 September 2016

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

scientific article published on 27 April 2012

Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.

scientific article published on 29 January 2018

Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs

scientific article published on 24 July 2018

Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy.

scientific article published on 16 March 2011

Preparation of a cross-linked porous protein crystal containing Ru carbonyl complexes as a CO-releasing extracellular scaffold

scientific article

Single-cell bioluminescence imaging of deep tissue in freely moving animals

scientific article

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold

scientific article published on 17 April 2020

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.

scientific article published on 30 April 2015

List of works by Takahiro Kuchimaru

A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.

A metal carbonyl-protein needle composite designed for intracellular CO delivery to modulate NF-κB activity

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia.

Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation

Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging

Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release

Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model

In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe

Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes

Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.

Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs

Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy.

Preparation of a cross-linked porous protein crystal containing Ru carbonyl complexes as a CO-releasing extracellular scaffold

Single-cell bioluminescence imaging of deep tissue in freely moving animals

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.