List of works - David Ginsburg

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.

scientific article

A diagnosis of discernment: Identifying a novel ATRX mutation in myelodysplastic syndrome with acquired α-thalassemia

scientific article published on 09 January 2019

A von Willebrand factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor VIII in mice

scientific article

Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B.

scientific article

Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo

scientific article published on 01 May 2018

Cargo selection in endoplasmic reticulum–to–Golgi transport and relevant diseases

scientific article published in 2023

Characterization of large structural genetic mosaicism in human autosome

journal article published in 2015

Detectable clonal mosaicism from birth to old age and its relationship to cancer

scientific article

Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents.

scientific article published on 7 February 2014

Dimeric sorting code for concentrative cargo selection by the COPII coat.

scientific article published on 19 March 2018

Disruption of the Sec24d gene results in early embryonic lethality in the mouse

scientific journal article

Exocyst function is regulated by effector phosphorylation.

scientific article published on 24 April 2011

Functional display of platelet-binding VWF fragments on filamentous bacteriophage

scientific article

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo

scientific article published on 31 July 2018

Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels

scientific article published on 19 June 2017

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels

scientific article

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

scientific article published on 19 December 2016

Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance.

scientific article published on 30 June 2016

High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13.

scientific article published on 12 February 2018

Introduction of Francis S. Collins.

scientific article

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association

scientific article

Mammalian COPII coat component SEC24C is required for embryonic development in mice

scientific journal article

Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.

scientific article published on 13 July 2015

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin

scientific journal article

Murine coagulation factor VIII is synthesized in endothelial cells.

scientific article

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice

scientific article published on 14 June 2016

Probing ADAMTS13 substrate specificity using phage display

scientific article published on 7 April 2015

SEC23B is required for pancreatic acinar cell function in adult mice

scientific article published on 24 May 2017

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

scientific article

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

scientific article

Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice

scientific article

Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele ⬇️

scientific article published on September 13, 2010

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

scientific article published on 25 June 2018

The COPII pathway and hematologic disease

scientific article

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

scientific article

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

scientific article published on 25 September 2018

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

scientific article published on 11 November 2019

The molecular biology of von Willebrand disease

scientific article published on 01 May 1999

Training the next generation of biomedical investigators in glycosciences

scientific article published on February 2016

Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII

scientific article

Von Willebrand Factor and ADAMTS13: Too Much or Too Little of a Good Thing?

scientific article published in December 2016

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

scientific article published on 06 September 2018

List of works by David Ginsburg

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation.

A diagnosis of discernment: Identifying a novel ATRX mutation in myelodysplastic syndrome with acquired α-thalassemia

A von Willebrand factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor VIII in mice

Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B.

Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo

Cargo selection in endoplasmic reticulum–to–Golgi transport and relevant diseases

Characterization of large structural genetic mosaicism in human autosome

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents.

Dimeric sorting code for concentrative cargo selection by the COPII coat.

Disruption of the Sec24d gene results in early embryonic lethality in the mouse

Exocyst function is regulated by effector phosphorylation.

Functional display of platelet-binding VWF fragments on filamentous bacteriophage

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo

Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance.

High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13.

Introduction of Francis S. Collins.

Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association

Mammalian COPII coat component SEC24C is required for embryonic development in mice

Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin

Murine coagulation factor VIII is synthesized in endothelial cells.

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice

Probing ADAMTS13 substrate specificity using phage display

SEC23B is required for pancreatic acinar cell function in adult mice

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice

Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele ⬇️

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

The COPII pathway and hematologic disease

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

The molecular biology of von Willebrand disease

Training the next generation of biomedical investigators in glycosciences

Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII

Von Willebrand Factor and ADAMTS13: Too Much or Too Little of a Good Thing?

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse