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List of works by Wenqing Chen

Activation of Natural Products Biosynthetic Pathways via a Protein Modification Level Regulation.

scientific article published on 31 May 2017

An ATP-dependent ligase with substrate flexibility involved in assembly of the peptidyl nucleoside antibiotic polyoxin.

scientific article

An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

scientific article published on 14 July 2016

Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365. ⬇️

scientific article published on 3 March 2017

Biosynthesis of 4-aminoheptose 2-epimers, core structural components of the septacidins and spicamycins.

scientific article

Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570 ⬇️

scientific article

Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.

scientific article

Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds

scientific article published on 07 January 2020

Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics.

scientific article published on 19 August 2016

Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes

scientific article published on 30 October 2018

Deciphering Carbamoylpolyoxamic Acid Biosynthesis Reveals Unusual Acetylation Cycle Associated with Tandem Reduction and Sequential Hydroxylation.

scientific article published on August 2016

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090 ⬇️

scientific article published in 2018

Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics.

scientific article published on 24 March 2012

Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster

scientific article

Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks

scientific article

Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396.

scientific article

Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL30471 ⬇️

scientific article

Identification of the genecluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471 ⬇️

scientific article published on December 23, 2010

Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics

scientific article published on 12 May 2015

Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

scientific article published on 08 July 2015

PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi.

scientific article published on 17 November 2009

polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.

scientific article

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