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List of works by Frank Lyko

5-methylcytosine in RNA: detection, enzymatic formation and biological functions

scientific article

A Dnmt2-like protein mediates DNA methylation in Drosophila

scientific article published on 27 August 2003

Aging and chronic sun exposure cause distinct epigenetic changes in human skin

scientific article

Aging is associated with highly defined epigenetic changes in the human epidermis.

scientific article published on 31 October 2013

Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines

scientific article

Azacytidine and Decitabine Induce Gene-Specific and Non-Random DNA Demethylation in Human Cancer Cell Lines ⬇️

scientific article published on March 7, 2011

Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines

scientific article published on 6 October 2009

BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis

scientific article published on 24 October 2018

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

scientific article published on 01 June 2018

Characterization of genome methylation patterns in the desert locust Schistocerca gregaria.

scientific article published on 21 December 2012

Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer

scientific article

Clonal genome evolution and rapid invasive spread of the marbled crayfish.

scientific article

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

scientific article published on 24 January 2013

Comparative analysis of DNA methylation patterns in transgenic Drosophila overexpressing mouse DNA methyltransferases

scientific article published in March 2004

Comprehensive DNA methylation analysis of the Aedes aegypti genome

scientific article (publication date: 2 November 2016)

Cooperative interactions between epigenetic modifications and their function in the regulation of chromosome architecture

scientific article

DAZAP2 acts as specifier of the p53 response to DNA damage

scientific article published on 01 March 2021

DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries

scientific article published on 04 April 2019

DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications

scientific article

DNA methylation with a sting: an active DNA methylation system in the honeybee

scientific article published in March 2007

De Novo assembly and annotation of the freshwater crayfish Astacus astacus transcriptome.

scientific article

Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy

scientific article

Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast

scientific article published on 01 February 2019

Dnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum

scientific article published in Scientific Reports

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

scientific article published on 25 April 2018

Dnmt2-dependent methylomes lack defined DNA methylation patterns

scientific article published on 2 May 2013

Dnmt3a Protects Active Chromosome Domains against Cancer-Associated Hypomethylation ⬇️

scientific article published on December 20, 2012

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

scientific article published on 30 September 2015

Ecological plasticity and commercial impact of invasive marbled crayfish populations in Madagascar ⬇️

scientific article published on 06 February 2019

Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.

scientific article published on February 2013

Epigenetic cancer therapy: Proof of concept and remaining challenges ⬇️

scientific article published on November 1, 2010

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

scientific article published on 25 May 2020

Epigenetic regulation by heritable RNA.

scientific article

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

scientific article

Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells

scientific article

Evaluating Invasive Marbled Crayfish as a Potential Livestock for Sustainable Aquaculture

scientific article published on 12 August 2021

Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo

scientific article

Genetic and epigenetic profiling of a solitary Peutz-Jeghers colon polyp.

scientific article published on May 2017

Genome analysis of the monoclonal marbled crayfish reveals genetic separation over a short evolutionary timescale

scientific article

Genome recoding by tRNA modifications

scientific article

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

scientific article published on 22 March 2011

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

scientific article published on 8 May 2012

LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation.

scientific article published on 19 April 2006

Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation

scientific article published in November 2010

Limited antibody specificity compromises epitranscriptomic analyses

scientific article published on 11 December 2019

Location-Dependent DNA Methylation Signatures in a Clonal Invasive Crayfish ⬇️

scientific article published on 09 December 2021

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells

scientific article

MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma.

scientific article published on 13 December 2012

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

scientific article published on 27 May 2016

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.

scientific article published on 8 February 2018

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

scientific article published in February 2018

Non-mammalian models for epigenetic analyses in cancer.

scientific article published on April 2007

Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors

scientific article

Perceived socio-economic impacts of the marbled crayfish invasion in Madagascar ⬇️

scientific article published on 15 April 2020

Phylogeographic reconstruction of the marbled crayfish origin

scientific article published on 17 September 2021

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

scientific article published on 19 April 2018

Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells

scientific article published on 26 August 2014

Queuine links translational control in eukaryotes to a micronutrient from bacteria

scientific article published on 01 April 2019

Queuosine-modified tRNAs confer nutritional control of protein translation

scientific article published on 09 August 2018

RNA cytosine methylation analysis by bisulfite sequencing

scientific article

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

scientific article published on 12 August 2012

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

scientific article

RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.

scientific article

Rapid Epigenetic Adaptation in Animals and Its Role in Invasiveness

scientific article published on 18 April 2020

Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications

scientific article published on 29 November 2005

Reduced DNA methylation patterning and transcriptional connectivity define human skin aging.

scientific article published on 23 March 2016

Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi

scientific article

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

scientific article published on 23 April 2020

Solving the Dnmt2 enigma.

scientific article published on February 2010

Stable ethnic variations in DNA methylation patterns of human skin.

scientific article published on 13 October 2011

Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation

scientific article published in March 2002

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs

scientific article

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation

scientific article

The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA.

scientific article published on 10 November 2004

The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis

scientific article

The RNA methyltransferase Dnmt2 is required for efficient Dicer-2-dependent siRNA pathway activity in Drosophila

scientific article published on 5 September 2013

The aging epigenome: DNA methylation from the cradle to the grave ⬇️

scientific article published on July 30, 2012

The importance of non-histone protein methylation in cancer therapy

scientific article published on 01 October 2019

The marbled crayfish (Decapoda: Cambaridae) represents an independent new species

scientific article published on 12 December 2017

The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals

scientific article

The methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes

article

The microbiota programs DNA methylation to control intestinal homeostasis and inflammation

scientific article published on 03 February 2020

The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation

scientific journal article

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

scientific article

Transcriptional programs that control expression of the autoimmune regulator gene Aire

scientific article published on 12 December 2016

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia

scientific article published on 17 May 2018

Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans

scientific article published on 07 December 2020

Two substrates are better than one: dual specificities for Dnmt2 methyltransferases

scientific article

Use of DNAzymes for site-specific analysis of ribonucleotide modifications

scientific article published on 12 November 2007

mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation

scientific article published on 20 September 2017

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