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List of works by Catherine Shanahan

A potential role for sterol 27-hydroxylase in atherogenesis.

scientific article

A regulatory element downstream of the rat SM22 alpha gene transcription start point enhances reporter gene expression in vascular smooth muscle cells.

scientific article published on March 1995

Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis.

scientific article

Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies

scientific article published on 01 November 2000

Approaches to the development of selective inhibitors of vascular smooth muscle cell proliferation.

scientific article

Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes

scientific article

Arterial calcification in chronic kidney disease: key roles for calcium and phosphate

scientific article

BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway

scientific article published on 9 October 2014

Biology of calcification in vascular cells: intima versus media

scientific article

Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension

scientific article

Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression

scientific article published on 01 March 1998

Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification.

scientific article

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.

scientific article published on 20 December 2017

Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization.

scientific article published on 12 May 2011

Calcium regulation of vascular smooth muscle cell-derived matrix vesicles.

scientific article published on July 2012

Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.

scientific article

Citrate occurs widely in healthy and pathological apatitic biomineral: mineralized articular cartilage, and intimal atherosclerotic plaque and apatitic kidney stones.

scientific article published on 19 June 2013

Clinical outcomes in secondary hyperparathyroidism and the potential role of calcimimetics

scientific article published on January 2008

Crystallizing nanoparticles derived from vascular smooth muscle cells contain the calcification inhibitor osteoprotegerin ⬇️

scientific article published on April 1, 2011

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

scientific article published on January 2017

Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging ⬇️

scientific article published on December 1, 2011

Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis

scientific article published on 06 October 2008

Differential Gene Expression in Vascular Smooth Muscle Cells in Primary Atherosclerosis and In Stent Stenosis in Humans

article

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

scientific article published on 27 September 2016

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy

scientific article

ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism

scientific article published on 16 July 2018

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

scientific article

Endoplasmic Reticulum Stress in Arterial Smooth Muscle Cells: A Novel Regulator of Vascular Disease

scientific article published in May 2017

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

scientific article published on 13 October 2017

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

scientific article published on 20 March 2017

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

scientific article

HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype

scientific article

High expression of genes for calcification-regulating proteins in human atherosclerotic plaques.

scientific article

High expression of osteopontin mRNA in human macrophages but not human vascular smooth muscle cells in culture

scientific article published on 01 April 1995

Human vascular smooth muscle cell culture

scientific article published on 01 January 2012

Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.

scientific article published in November 2004

Identification and Validation of Putative Nesprin Variants

scientific article published on 01 January 2016

Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies

scientific article

Identification of osteoglycin as a component of the vascular matrix. Differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques

scientific article published on 01 November 1997

In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR.

scientific article published in December 2017

Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells.

scientific article

Inflammation ushers in calcification: a cycle of damage and protection?

scientific article published on 01 December 2007

Inhibition of TNF-α Reverses the Pathological Resorption Pit Profile of Osteoclasts from Patients with Acute Charcot Osteoarthropathy.

scientific article published on 2 June 2015

Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells.

scientific article published on July 1993

Klotho: an elixir of youth for the vasculature?

scientific article published on 16 December 2010

Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype.

scientific article

Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins

scientific article

Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions

scientific article published on 01 June 2001

Lipids in biocalcification: contrasts and similarities between intimal and medial vascular calcification and bone by NMR

scientific article published on 31 May 2012

Magnesium Counteracts Vascular Calcification: Passive Interference or Active Modulation?

scientific article

Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation.

scientific article published in February 2018

Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes

scientific article

Mechanisms of vascular calcification in CKD-evidence for premature ageing?

scientific article published on 10 September 2013

Mechanistic insights into vascular calcification in CKD.

scientific article

Medial Arterial Calcification: An Overlooked Player in Peripheral Arterial Disease.

scientific article published on 16 June 2016

Medial vascular calcification revisited: review and perspectives

scientific article

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.

scientific article published in December 1994

Molecular mechanisms mediating vascular calcification: role of matrix Gla protein.

scientific article

Multifunctional Roles for Serum Protein Fetuin-A in Inhibition of Human Vascular Smooth Muscle Cell Calcification

scientific article published on 10 August 2005

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds

scientific article published in 2012

Muscle tensions merge to cause a DNA replication crisis

scientific article published on 16 May 2018

N-terminal nesprin-2 variants regulate β-catenin signalling

scientific article published on 16 June 2016

NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization

scientific article published in May 2014

Nanocrystals seed calcification in more ways than one

scientific article published on 01 February 2011

Neointimal hyperplasia and calcification in medium sized arteries in adult patients with chronic kidney disease.

scientific article published on 9 December 2014

Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy.

scientific article published on 13 December 2010

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration

scientific article published on 25 June 2014

Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease.

scientific article published on 27 February 2018

Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle

scientific article

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing

scientific article

Nesprins LINC the nucleus and cytoskeleton ⬇️

scientific article published on December 20, 2010

Nesprins: tissue-specific expression of epsilon and other short isoforms.

scientific article

Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy.

scientific article published on 03 October 2013

Not all vascular smooth muscle cell exosomes calcify equally in chronic kidney disease.

scientific article published in February 2018

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

scientific article

Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.

scientific article published on 27 October 2009

Novel use of a Dektak 150 surface profiler unmasks differences in resorption pit profiles between control and Charcot patient osteoclasts.

scientific article published on 10 December 2013

Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification

scientific article published on 30 January 2003

Osteocalcin: a novel vascular metabolic and osteoinductive factor?

scientific article published on 01 October 2011

Osteopontin expression and calcium content in human aortic valves

scientific article published on 01 August 2000

Osteopontin is not a marker for proliferating human vascular smooth muscle cells

scientific article published on 01 November 1995

Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 deficiency

article by Carolina Prando et al published March 2010 in American Journal of Medical Genetics

Phosphodiesterase 1 regulation is a key mechanism in vascular aging

scientific article published on 25 June 2015

Polyubiquitin is a new phenotypic marker of contractile vascular smooth muscle cells.

scientific article published on February 1997

Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.

scientific article

Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells.

scientific article

Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.

scientific article published on 5 April 2013

Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging

scientific article

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

scientific article published on 27 July 2016

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification.

scientific article published on 19 January 2017

RNA granules and cytoskeletal links.

scientific article

Regulation of expression of a sheep metallothionein 1a-sheep growth hormone fusion gene in transgenic mice.

scientific article published on December 1989

Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

scientific article published on 01 May 2008

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.

scientific article published in March 2018

Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

scientific article published on 24 December 2020

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

scientific article

Signalling pathways and vascular calcification

scientific article

Smooth muscle cell phenotypes in atherosclerotic lesions.

scientific article

Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.

scientific article

Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification?

scientific article published on 01 September 2003

TGF-beta superfamily members do not promote smooth muscle-specific alternative splicing, a late marker of vascular smooth muscle cell differentiation.

scientific article published on August 2000

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling

scientific article published on 7 January 2016

Technetium-99m and rhenium-188 complexes with one and two pendant bisphosphonate groups for imaging arterial calcification.

scientific article

The Id gene is activated by serum but is not required for de-differentiation in rat vascular smooth muscle cells.

scientific article published on July 1991

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton ⬇️

scientific article published on June 7, 2011

The aquaporins. A family of water channel proteins.

scientific article published in February 1998

The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis

scientific article published on 07 May 2008

The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages

scientific article

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300

scientific article

The nuclear lamina in health and disease.

scientific article published on 9 May 2016

The vascular biology of calcification.

scientific article published on March 2007

UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015

scientific article published on 14 May 2015

Vascular calcification

scientific article published on 01 July 2005

Vascular calcification and hypertension: cause and effect.

scientific article published on June 2012

Vascular calcification--a matter of damage limitation?

scientific article published on 07 March 2006

Vascular calcification: new insights into an old problem

scientific article published on 01 May 1998

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

scientific article published on 23 February 2015

Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification.

scientific article published on September 2006

Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype

scientific article

Water channels in health and disease

scientific article published on 01 January 1996

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