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List of works by Andrew P. Degnan

A unified approach to the tedanolides: total synthesis of (+)-13-deoxytedanolide.

scholarly article

Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors

scientific article published on 2 June 2015

Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.

scientific article published on 8 May 2009

Catalytic asymmetric syntheses of alpha-amino and alpha-hydroxyl acid derivatives

scientific article published on 01 May 2009

Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.

scientific article published on 30 November 2012

Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.

scientific article

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential

scientific article published on 9 November 2016

Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5

scientific article published on 4 January 2016

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related

scientific article published on 30 July 2008

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression

scientific article published on 17 October 2016

Enantioselective synthesis of rigid 2-aminotetralins. Utility of silicon as an oxygen and nitrogen surrogate in the tandem addition reaction

scientific article published on 01 June 2000

Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5

scientific article published on 29 January 2015

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.

scientific article published on 28 July 2016

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes

scientific article

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2

scientific article published on 24 January 2013

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