List of works - Hisashi Umemori

5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

scientific article

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.

scientific article published on 21 December 2016

ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

scientific article

Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function

scientific article published on 10 December 2016

An activity-dependent determinant of synapse elimination in the mammalian brain

scientific article published on 25 March 2021

Buttressing a balanced brain: Target-derived FGF signaling regulates excitatory/inhibitory tone and adult neurogenesis within the maturating hippocampal network

scientific article published on 12 April 2016

Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.

scientific article published on 29 March 2016

Distinct FGFs promote differentiation of excitatory and inhibitory synapses

scientific article published on 26 May 2010

Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis

scientific article published on 29 April 2015

Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals

scientific journal article

Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling

scientific article published on 01 September 1999

Excitability governs neural development in a hippocampal region-specific manner

scientific article

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain

scientific article

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord

scientific article

Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus

scientific article published on 10 January 2012

Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors

scientific article (publication date: 31 January 2003)

Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling

scientific article

Impairment of N-methyl-d-aspartate receptor-controlled motor activity in LYN-deficient mice ⬇️

scientific article published on January 1, 2003

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

scientific article

Involvement of protein tyrosine phosphatases in activation of the trimeric G protein Gq/11

Mice lacking a transcriptional corepressor Tob are predisposed to cancer

scientific article

Multiple forms of activity-dependent competition refine hippocampal circuits in vivo

scientific article published on June 2011

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

scientific article published on 30 November 2010

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

scientific article

Negative regulation of BMP/Smad signaling by Tob in osteoblasts

scientific article (publication date: 22 December 2000)

Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development

scientific article published on 3 August 2012

Orchestrating the synaptic network by tyrosine phosphorylation signalling

scientific article

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A

scientific article

Phosphorylation-dependent interaction of the N-methyl- d-aspartate receptor epsilon2 subunit with phosphatidylinositol 3-kinase

scientific article published on 01 November 1999

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

scientific article

Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation

scientific article published on 15 September 2016

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

scientific article

Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.

scientific article published on 9 March 2008

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

scientific article published on 15 April 2016

Secreted factors as synaptic organizers

scientific article published on 14 July 2010

Seeking long-term relationship: axon and target communicate to organize synaptic differentiation

scientific article

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.

scientific article

Signal regulatory proteins (SIRPS) are secreted presynaptic organizing molecules

scientific article published on 26 September 2008

Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system

scientific article (publication date: December 1992)

Specific sets of intrinsic and extrinsic factors drive excitatory and inhibitory circuit formation

scientific article published on 07 June 2011

Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

scientific article published on August 1998

Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.

scientific article published in February 1999

Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice

scientific article

Synapse maturation by activity-dependent ectodomain shedding of SIRPα.

scientific article published on 15 September 2013

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

scientific article

The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease.

scientific article published on 18 March 2014

The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.

scientific article

Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling

scientific article (publication date: May 2003)

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation

scientific article published in Journal of Biological Chemistry

Weaving the neuronal net with target-derived fibroblast growth factors

scientific article published on 19 December 2008

p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling

2003 scientific article

List of works by Hisashi Umemori

5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.

ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function

An activity-dependent determinant of synapse elimination in the mammalian brain

Buttressing a balanced brain: Target-derived FGF signaling regulates excitatory/inhibitory tone and adult neurogenesis within the maturating hippocampal network

Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.

Distinct FGFs promote differentiation of excitatory and inhibitory synapses

Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis

Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals

Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling

Excitability governs neural development in a hippocampal region-specific manner

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord

Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus

Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors

Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling

Impairment of N-methyl-d-aspartate receptor-controlled motor activity in LYN-deficient mice ⬇️

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

Involvement of protein tyrosine phosphatases in activation of the trimeric G protein Gq/11

Mice lacking a transcriptional corepressor Tob are predisposed to cancer

Multiple forms of activity-dependent competition refine hippocampal circuits in vivo

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

Negative regulation of BMP/Smad signaling by Tob in osteoblasts

Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development

Orchestrating the synaptic network by tyrosine phosphorylation signalling

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A

Phosphorylation-dependent interaction of the N-methyl- d-aspartate receptor epsilon2 subunit with phosphatidylinositol 3-kinase

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain

Secreted factors as synaptic organizers

Seeking long-term relationship: axon and target communicate to organize synaptic differentiation

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.

Signal regulatory proteins (SIRPS) are secreted presynaptic organizing molecules

Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system

Specific sets of intrinsic and extrinsic factors drive excitatory and inhibitory circuit formation

Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.

Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice

Synapse maturation by activity-dependent ectodomain shedding of SIRPα.

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease.

The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.

Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation

Weaving the neuronal net with target-derived fibroblast growth factors

p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling