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List of works by Hamsa Puthalakath

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

scientific article published on 16 July 2019

BH3-Only Proteins in Health and Disease

scientific article published on 28 September 2016

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

scientific article (publication date: 21 February 2002)

BH3-only proteins: a 20-year stock-take

scientific article

BH3-only proteins: the thorny end of the ER stress response

scientific article published on 22 June 2017

Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.

scientific article published on June 2008

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

scientific article

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

scientific article published on 25 December 2005

CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis

scientific article published on 12 April 2013

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice

scientific article (publication date: 3 October 2016)

Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

scientific article published on 07 September 2020

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins

scientific article

Cre transgene results in global attenuation of the cAMP/PKA pathway

scientific article

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

scientific journal article

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

scientific article published on 14 April 2017

ER stress triggers apoptosis by activating BH3-only protein Bim

scientific article (publication date: 29 June 2007)

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate.

scientific article published on 11 April 2004

Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma

scientific article published on 22 February 2007

Endoplasmic Reticulum Stress and BCL-2 Family Members ⬇️

scientific article published on January 1, 2010

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

scientific article published on 31 July 2014

Experimental In Vivo Sepsis Models to Monitor Immune Cell Apoptosis and Survival in Laboratory Mice

scientific article published on January 2016

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

Fold up or perish: unfolded protein response and chemotherapy

scientific article

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

scientific article

Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant.

scientific article published on December 1998

Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene.

scientific article published on November 1996

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

scientific article published on 19 July 2013

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

Isolation of Cardiomyocytes and Cardiofibroblasts for Ex Vivo Analysis

scientific article published in 2016

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

scientific article published on 03 June 2018

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

scientific article

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

scientific article published on 11 July 2014

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

scientific article

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

scientific article published on July 2009

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

scientific article published on July 2004

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation.

scientific article

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

scientific article published on 01 May 2019

Rapid selection against truncation mutants in yeast reverse two-hybrid screens.

scientific article

Role of p53 in cAMP/PKA pathway mediated apoptosis.

scientific article published on December 2013

Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection

scientific article published on 15 July 2019

Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway

scientific article published on 30 May 2019

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

scientific article published in January 2005

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

scientific article published on 05 October 2020

The PKA paradox: Is Bim the answer? ⬇️

scientific article published on March 1, 2011

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

scientific article (publication date: March 1999)

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

scientific article published in May 2008

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome

scientific article (publication date: December 2015)

Ubiquitylation and cancer development

scientific article published on March 2008

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.

scientific article

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

scientific article

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