List of works - David Langley

A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer

scientific article

A novel structure of an antikinase and its inhibitor

scientific article

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis

scientific article

Complexes of the copper-containing amine oxidase fromArthrobacter globiformiswith the inhibitors benzylhydrazine and tranylcypromine

scientific article

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

scientific article published on 27 August 2020

Crystal structure of duck egg lysozyme isoform II (DEL-II)

scientific article published on 22 August 2018

Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop

scientific article

Crystallization and diffraction of an Lhx4-Isl2 complex.

scientific article published on 31 January 2009

Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex

scientific article

Crystallization of GcnA, an N-acetyl-beta-D-glucosaminidase, from Streptococcus gordonii

scientific article published on 23 September 2004

Crystallization of Pichia pastoris lysyl oxidase

scientific article published on 23 November 2002

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

scientific article published in November 2017

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation

scientific article

Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter globiformis

scientific article

Expression of high-affinity human antibody fragments in bacteria.

scientific article

Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies

scientific article

General strategy for the generation of human antibody variable domains with increased aggregation resistance

scientific article

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

scientific article published in April 2018

Histidine kinase regulation by a cyclophilin-like inhibitor

scientific article

Human Antibody Bispecifics through Phage Display Selection

scientific article published on 22 March 2019

Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis

scientific article published on March 2004

I-motif DNA structures are formed in the nuclei of human cells.

scientific article published on 23 April 2018

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

scientific article published on 29 October 2021

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein

scientific article published on 28 November 2007

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

scientific article published on 13 February 2020

Next-Generation Sequencing of Antibody Display Repertoires.

scientific article published on 2 February 2018

Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis

scientific article

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.

scientific article

Protein A superantigen: structure, engineering and molecular basis of antibody recognition

scientific article published on 01 December 2019

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

scientific article

Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires

scientific article

Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH

scientific article

Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification

scientific article

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

scientific article published on 25 October 2017

Structural reconstruction of protein ancestry

scientific article

Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum

scientific article

Structure of GUN4 from Chlamydomonas reinhardtii

scientific article published on 29 July 2015

Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline

scientific article

Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state

scientific article

Systematic functional identification of cancer multi-drug resistance genes

scientific article published on 07 February 2020

The 1.23 Angstrom structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link

scientific article published on 19 August 2006

The Bacillus subtilis DNA replication terminator.

scientific article

The Structure of the KinA-Sda Complex Suggests an Allosteric Mechanism of Histidine Kinase Inhibition

scientific article published on 03 February 2007

The copper-containing amine oxidase from Arthrobacter globiformis: refinement at 1.55 and 2.20 A resolution in two crystal forms

scientific article

The crystal structure of Pichia pastoris lysyl oxidase

scientific article

The minimal sequence needed to define a functional DNA terminator in Bacillus subtilis

scientific article published on 01 August 1994

The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis

scientific article published in September 2011

The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase

scientific article

Using xenon as a probe for dioxygen-binding sites in copper amine oxidases.

scientific article published in November 2004

List of works by David Langley

A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer

A novel structure of an antikinase and its inhibitor

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis

Complexes of the copper-containing amine oxidase fromArthrobacter globiformiswith the inhibitors benzylhydrazine and tranylcypromine

Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

Crystal structure of duck egg lysozyme isoform II (DEL-II)

Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop

Crystallization and diffraction of an Lhx4-Isl2 complex.

Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex

Crystallization of GcnA, an N-acetyl-beta-D-glucosaminidase, from Streptococcus gordonii

Crystallization of Pichia pastoris lysyl oxidase

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation

Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter globiformis

Expression of high-affinity human antibody fragments in bacteria.

Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies

General strategy for the generation of human antibody variable domains with increased aggregation resistance

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Histidine kinase regulation by a cyclophilin-like inhibitor

Human Antibody Bispecifics through Phage Display Selection

Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis

I-motif DNA structures are formed in the nuclei of human cells.

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

Next-Generation Sequencing of Antibody Display Repertoires.

Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.

Protein A superantigen: structure, engineering and molecular basis of antibody recognition

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires

Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH

Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

Structural reconstruction of protein ancestry

Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum

Structure of GUN4 from Chlamydomonas reinhardtii

Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline

Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state

Systematic functional identification of cancer multi-drug resistance genes

The 1.23 Angstrom structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link

The Bacillus subtilis DNA replication terminator.

The Structure of the KinA-Sda Complex Suggests an Allosteric Mechanism of Histidine Kinase Inhibition

The copper-containing amine oxidase from Arthrobacter globiformis: refinement at 1.55 and 2.20 A resolution in two crystal forms

The crystal structure of Pichia pastoris lysyl oxidase

The minimal sequence needed to define a functional DNA terminator in Bacillus subtilis

The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis

The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase

Using xenon as a probe for dioxygen-binding sites in copper amine oxidases.