List of works - Alexandra Grubman

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

scientific article published on 01 December 2019

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

scientific article published on 20 May 2013

Copper as a key regulator of cell signalling pathways.

scientific article published on 22 May 2014

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

Cu(atsm) Attenuates Neuroinflammation

scientific article published on 24 September 2018

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

scientific article

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

scientific article

Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6nclf Mice

scientific article published on 01 October 2018

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

scientific article published on 29 July 2018

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

scientific article published on 13 April 2020

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

scientific article published on 11 February 2014

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

scientific article

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

scientific article

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.

scientific article published on 21 July 2017

Mitochondrial metals as a potential therapeutic target in neurodegeneration

scientific article published on April 2014

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

scientific article published on 22 September 2016

Neuroinflammation and copper in Alzheimer's disease.

scientific article

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

scientific article

Nucleotide oligomerization domain 1 enhances IFN-γ signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity.

scientific article published on 4 March 2013

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

scientific article

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

scientific article

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

scientific article published on 17 October 2013

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

scientific article

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

scientific article

The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides

scientific article

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

scientific article published on 21 May 2021

Vitamin B 6 Is Required for Full Motility and Virulence in Helicobacter pylori ⬇️

scientific article published on August 17, 2010

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

scientific article

X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age.

scientific article published on 2 August 2016

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

scientific article

List of works by Alexandra Grubman

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Copper as a key regulator of cell signalling pathways.

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Cu(atsm) Attenuates Neuroinflammation

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6nclf Mice

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.

Mitochondrial metals as a potential therapeutic target in neurodegeneration

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

Neuroinflammation and copper in Alzheimer's disease.

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

Nucleotide oligomerization domain 1 enhances IFN-γ signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Vitamin B 6 Is Required for Full Motility and Virulence in Helicobacter pylori ⬇️

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age.

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.