List of works - Päivi M Ojala

A novel virus-host cell membrane interaction. Membrane voltage-dependent endocytic-like entry of bacteriophage straight phi6 nucleocapsid.

scientific article published on November 1999

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

scientific article

Bacteriophage phi 6 envelope elucidated by chemical cross-linking, immunodetection, and cryoelectron microscopy.

scientific article

Cell signaling pathways engaged by KSHV.

scientific article published on 19 May 2006

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

scientific article

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

scientific article

Generation of infectious nucleocapsids by in vitro assembly of the shell protein on to the polymerase complex of the dsRNA bacteriophage phi 6.

scientific article published in April 1991

Genome organization of membrane-containing bacteriophage PRD1.

scientific article published on August 1991

HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses

scientific article published on 24 June 2020

Herpes simplex virus type 1 entry into host cells: reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro

scientific article

In Vitro Transcription of the Double-Stranded RNA Bacteriophage φ6 Is Influenced by Purine NTPs and Calcium

scientific article published on 01 March 1995

Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses

scientific article published on October 2012

Intermediates in the assembly pathway of the double-stranded RNA virus phi 6 ⬇️

scientific article published on July 16, 1997

KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.

scientific article published on 22 July 2004

KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas.

scientific article

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

scientific article

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

scientific article published in December 2011

Kaposi (KS) pathogenesis: cell origin, HHV-8 permissiveness, proliferation, genomic instability.

scientific article published on 21 December 2006

Kaposi sarcoma herpesvirus lytic replication is independent of the anaphase promoting complex activity

scientific article published on 15 April 2020

Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

scientific article published on 27 August 2020

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

scientific article published on 2 April 2012

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis

scientific article

Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesis

scientific article

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.

scientific article

Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6.

scientific article published on October 1999

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

scientific article published in May 2018

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

scientific article

Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation

scientific article published on 28 January 2014

NTP Binding Induces Conformational Changes in the Double-Stranded RNA Bacteriophage ø6 Subviral Particles

scientific article published on 01 November 1994

Naughty chaperone as a target for viral cancer.

scientific article published on October 2013

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

scientific article

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency

scientific article

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

scientific article published on 18 February 2016

Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

scientific article published on 21 January 2021

Oncogenic herpesvirus engages endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

scientific article published on 09 June 2020

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

scientific article

Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest.

scientific article

Protein P4 of double-stranded RNA bacteriophage phi 6 is accessible on the nucleocapsid surface: epitope mapping and orientation of the protein ⬇️

scientific article published on May 1, 1993

Purified phi 6 nucleocapsids are capable of productive infection of host cells with partially disrupted outer membranes.

scientific article published in October 1990

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

scientific article published on 15 March 2007

The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.

scientific article published in November 2000

Viral infection--a diverse causative agent of cancer

scientific article published in January 2013

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis

scientific article

Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma

scientific article published on 9 December 2014

[Encouraging experiences of interactive lectures].

scientific article

p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas.

scientific article published on 10 July 2007

List of works by Päivi M Ojala

A novel virus-host cell membrane interaction. Membrane voltage-dependent endocytic-like entry of bacteriophage straight phi6 nucleocapsid.

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

Bacteriophage phi 6 envelope elucidated by chemical cross-linking, immunodetection, and cryoelectron microscopy.

Cell signaling pathways engaged by KSHV.

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Generation of infectious nucleocapsids by in vitro assembly of the shell protein on to the polymerase complex of the dsRNA bacteriophage phi 6.

Genome organization of membrane-containing bacteriophage PRD1.

HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses

Herpes simplex virus type 1 entry into host cells: reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro

In Vitro Transcription of the Double-Stranded RNA Bacteriophage φ6 Is Influenced by Purine NTPs and Calcium

Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses

Intermediates in the assembly pathway of the double-stranded RNA virus phi 6 ⬇️

KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas.

KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas.

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Kaposi (KS) pathogenesis: cell origin, HHV-8 permissiveness, proliferation, genomic instability.

Kaposi sarcoma herpesvirus lytic replication is independent of the anaphase promoting complex activity

Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis

Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesis

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.

Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6.

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation

NTP Binding Induces Conformational Changes in the Double-Stranded RNA Bacteriophage ø6 Subviral Particles

Naughty chaperone as a target for viral cancer.

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

Oncogenic herpesvirus engages endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest.

Protein P4 of double-stranded RNA bacteriophage phi 6 is accessible on the nucleocapsid surface: epitope mapping and orientation of the protein ⬇️

Purified phi 6 nucleocapsids are capable of productive infection of host cells with partially disrupted outer membranes.

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.

Viral infection--a diverse causative agent of cancer

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis

Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma

[Encouraging experiences of interactive lectures].

p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas.