List of works - Ashraf Brik

<i>In vivo</i> modulation of ubiquitin chains by <i>N</i>-methylated non-proteinogenic cyclic peptides

scientific article published in 2021

Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α-Globin-Modulating Deubiquitinase.

scientific article published on 12 March 2018

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

scientific article published on 10 June 2019

Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis

scientific article published on 19 May 2020

Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7

scientific article published on 14 December 2018

Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation

scientific article published in 2023

On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins

scientific article published on 02 November 2020

One-pot total chemical synthesis of human α-synuclein

scientific article published in October 2013

Palladium in the Chemical Synthesis and Modification of Proteins.

scientific article published on 6 April 2017

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

scientific article published on 01 June 2018

Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins

scientific article published in Nature Communications

Palladium-Mediated Cleavage of Proteins with Thiazolidine-Modified Backbone in Live Cells

scientific article published on 23 August 2019

Palladium-Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-cysteine under Aqueous Conditions

scientific article published on 20 March 2019

Switching Futile para-Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin-Specific Protease-2 Inhibition, Electrocatalysis, and Quantification

scientific article published on 22 June 2017

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

scientific article published on 16 September 2013

The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag

scientific article published on 26 October 2021

The Journey for the Total Chemical Synthesis of a 53 kDa Protein

scientific article published on 19 September 2019

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation

scientific article published on 16 August 2012

Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions

scientific article published on 24 February 2020

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

scientific article published on 05 April 2017

Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases

scientific article published on 11 January 2018

Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3.

scientific article published on 12 April 2017

Ubiquitin Signaling: Chemistry Comes to the Rescue

scientific article published on 22 March 2017

List of works by Ashraf Brik