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List of works by Dong Yang

A designer bleomycin with significantly improved DNA cleavage activity.

scientific article published on 06 August 2012

Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. ⬇️

scientific article published on 4 March 2015

Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion ⬇️

scientific article published on 3 September 2015

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

scientific article published on 10 September 2018

Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes

scientific article published on 31 January 2014

Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells.

scientific article

BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin

scientific article

Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. ⬇️

scientific article

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

scientific article published on 13 September 2018

Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D. ⬇️

scientific article

Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis

scientific article published on 19 January 2021

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

scientific article

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

scientific article

Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.

scientific article published on 18 January 2018

Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686

scientific article published on 10 May 2019

Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis ⬇️

scientific article published on 18 March 2021

Discovery of the leinamycin family of natural products by mining actinobacterial genomes ⬇️

scientific article published on 11 December 2017

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

scientific article

Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.

scientific article published on 23 August 2017

Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog

scientific article

Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes ⬇️

scientific article

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. ⬇️

scientific article published on 31 October 2017

Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.

scientific article

Germicidins H-J from Streptomyces sp. CB00361. ⬇️

scientific article

Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity

scientific article published on 22 February 2018

Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. ⬇️

scientific article published on August 2010

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

scientific article published on 18 November 2022

Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. ⬇️

scientific article

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883. ⬇️

scientific article

Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins

scientific article published on 10 November 2015

Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.

scientific article published on 12 December 2017

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

scientific article

Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. ⬇️

scientific article

Strain Prioritization and Genome Mining for Enediyne Natural Products

scientific article (publication date: 20 December 2016)

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

scientific article

The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells

scientific article published on 05 July 2018

Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026. ⬇️

scientific article

Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT–PCR ⬇️

scientific article published on December 4, 2010

Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.

scientific article published on 30 September 2016

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