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List of works by Joong Sup Shim

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment ⬇️

scientific article published on June 1, 2011

A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor

scientific article

Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3.

scientific article

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.

scientific article published in February 2004

Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

scientific article published on 30 October 2020

Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway

scientific article

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

scientific article

BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition

scientific article published on 24 July 2018

Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.

scientific article

Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression

scientific article published on 08 December 2020

Chemical genetics for therapeutic target mining

scientific article

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation ⬇️

scientific article published on November 14, 2011

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer.

scientific article published on 28 April 2019

Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.

scientific article published in April 2005

Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells.

scientific article published on 4 June 2007

Development of anangiogenesis-focused cDNA chip and validation of its functionality.

scientific article

Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system.

scientific article published on 29 May 2007

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth ⬇️

scientific article published on August 31, 2010

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

scientific article published on 22 January 2016

Effect of nitroxoline on angiogenesis and growth of human bladder cancer

scientific article

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells ⬇️

scientific article published on June 1, 2013

Existing drugs and their application in drug discovery targeting cancer stem cells.

scientific article published on 09 July 2015

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

scientific article published on 8 June 2015

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.

scientific article

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

scientific article

Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition.

scientific article published on 14 April 2008

Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

scientific article published on 01 September 2002

Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.

scientific article

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

scientific article

Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells ⬇️

scientific article published on February 1, 2013

Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism

scientific article published on 20 March 2015

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

scientific article published on 24 May 2021

PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A

scientific article published on 14 August 2018

Personalized chemotherapy profiling using cancer cell lines from selectable mice

scientific article

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.

scientific article published on 15 September 2017

Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.

scientific article published on March 2004

Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase-2 inhibitor, enoic acanthoic acid.

scientific article published on 19 September 2007

Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro.

scientific article published on January 2004

Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model

scientific article

Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

scientific article

Recent advances in drug repositioning for the discovery of new anticancer drugs

scientific article

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

scientific article

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

scientific article published on 2 December 2016

Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.

scientific article

Substituted oxines inhibit endothelial cell proliferation and angiogenesis.

scientific article published on 06 March 2012

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

scientific article published on 09 October 2020

Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

scientific article published in Nature Communications

Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

scientific article

The Small Molecule R-(-)-β-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis

scientific article published on 16 July 2015

Tricyclic thiazoles are a new class of angiogenesis inhibitors

scientific article published on 24 February 2013

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