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List of works by Daria Mochly-Rosen

A critical intramolecular interaction for protein kinase Cepsilon translocation

scientific article

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

scientific article published on 13 December 2012

A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo

scientific article published on 13 October 2011

A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant

scientific article published on 29 September 2014

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

scientific article published in Nature Communications

ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance

scientific article published on November 2011

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis

scientific article published on 27 January 2021

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo

scientific article

Acetylcholine receptor: molecular dissection and monoclonal antibodies in the study of experimental myasthenia ⬇️

scientific article published on 01 January 1981

Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats

scientific article published on 27 November 2008

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice

scientific article

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

scientific article

Activation of εPKC reduces reperfusion arrhythmias and improves recovery from ischemia: optical mapping of activation patterns in the isolated guinea-pig heart

scientific article

Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction

scientific journal article

Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator

scientific article

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites

scientific article

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology

scientific article published on 12 December 2019

Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells

scientific article

Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

scientific article

Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment

scientific article

Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells

scientific article published on 9 August 2010

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain

scientific article

Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats

scientific article published on 16 May 2008

An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin ⬇️

scientific article published on 01 August 1983

Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

scientific article published on 15 December 2020

Biodistribution of intracellularly acting peptides conjugated reversibly to Tat.

scientific article

C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo ⬇️

scientific article published on October 13, 1995

Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.

scientific article published on 20 December 2004

Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts

scientific article

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury

scientific article published on 29 April 2007

Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury

scientific article published in July 2004

Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis

scientific article published on August 2008

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

scientific article

Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption

scientific article

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

scientific article published in Nature Communications

Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants

scientific article

DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo

scientific article

Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

scientific article

Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities

scientific article published on 19 November 2016

Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways

scientific article published on 17 January 2008

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta

scientific article

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

scientific article published on 22 December 2017

Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics

scientific article published on 17 November 2016

Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice.

scientific article published in January 2003

Epsilon protein kinase C as a potential therapeutic target for the ischemic heart

scientific article

Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice

scientific article

Ethanol for cardiac ischemia: the role of protein kinase c.

scientific article published on December 2008

Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes

scientific article published in August 2005

Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma

scientific article

Exercise training restores cardiac protein quality control in heart failure

scientific article

Focus on: The cardiovascular system: what did we learn from the French (Paradox)?

scientific article published on January 2010

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

scientific article published on 23 September 2019

Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians.

scientific article

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

scientific article published on 7 December 2016

Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus

scientific article published on 28 February 2016

Glutathione S-transferase pull-down assay

scientific article published on January 2003

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death

scientific article

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury

scientific article published on 07 May 2013

Happy birthday protein kinase C: past, present and future of a superfamily

scientific article published on 18 May 2007

Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure

scientific article

Human Chitotriosidase Does Not Catabolize Hyaluronan

scientific article published on 13 December 2017

Identification of intracellular receptor proteins for activated protein kinase C ⬇️

scientific article published on May 1, 1991

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease

scientific article

Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage

scientific article published on 13 December 2006

In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2

scientific article

Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007).

scientific article

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

scientific article published on 15 January 2018

Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo

scientific article published on 3 November 2003

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration

scientific article

Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme

scientific article published on November 16, 1992

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function

scientific article published on 3 May 2007

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo

scientific article published in Scientific Reports

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme ⬇️

scientific article published on August 15, 1991

Intracellular transport mechanisms of signal transducers

scientific article

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction

scientific article published on 4 February 2008

Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion

scientific article

Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon

scientific article

Isozyme-specific inhibitors and activators of protein kinase C.

scientific article published in January 2002

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

scientific article published in April 2018

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

scientific article published on 26 November 2018

Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure

scientific article published on 04 September 2008

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells

scientific article published on 31 January 2011

Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice

scientific article published on 9 March 2012

Mitochondrial aldehyde dehydrogenase and cardiac diseases

scientific article

Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis

scientific article published on 27 February 2013

Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury

scientific article

Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases

scientific article published on May 2015

Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor ⬇️

scientific article published on August 25, 1980

Molecular dynamics characterization of the C2 domain of protein kinase Cbeta

scientific article published on 8 January 2002

Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes

scientific article published on 19 February 2018

Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site ⬇️

scientific article published on September 29, 1981

Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs ⬇️

scientific article published on 01 January 1983

Myocardial salvage in acute myocardial infarction--challenges in clinical translation

scientific article published on 12 August 2011

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies

scientific article published on 23 June 2021

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism

scientific article published on 28 September 2014

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

scientific article

Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation ⬇️

scientific article published on November 1, 1992

Nitroglycerin use in myocardial infarction patients

scientific article

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.

scientific article published on 28 August 2013

Non-volume-loaded heart provides a more relevant heterotopic transplantation model.

scientific article published on 18 April 2010

Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors

scientific article published on August 2003

Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery

scientific article published on December 2003

PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current

scientific article published in July 2003

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

scientific article published on January 2008

PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation

scientific article

PKC-{epsilon}-dependent survival signals in diabetic hearts

scientific article published on 13 May 2005

PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses

scientific article

PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells

scientific article published on 23 November 2010

PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting

scientific article published on 20 July 2013

Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells

scientific article published on 15 November 2006

Peptides and peptidomimetics as regulators of protein-protein interactions

scientific article published on 4 January 2017

Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces

scientific article

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats

scientific article

Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure

scientific article

Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy

scientific article

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo

scientific article

Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon

scientific article published on 4 November 2003

Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model

scientific article published on February 2008

Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta

scientific journal article

Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes ⬇️

scientific article published on 01 January 1995

Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.

scientific article published on 18 June 2006

Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation

scientific article

Protein kinase C delta mediates cerebral reperfusion injury in vivo.

scientific article

Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats

scientific article published on 4 February 2004

Protein kinase C in heart failure: a therapeutic target?

scientific article published on 24 January 2009

Protein kinase C, an elusive therapeutic target?

scientific article published on December 2012

Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria

scientific article published on 31 August 2004

Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons

scientific article published in February 2005

Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3

scientific article (publication date: 2012)

RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling

scientific article published on July 2004

RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function

scientific article published on 22 November 2006

RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death

scientific article

Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide

scientific article

Rationally designed peptide regulators of protein kinase C.

scientific article published on 04 December 2008

Regulation of cardiac excitability by protein kinase C isozymes

scientific article published on January 2012

Regulation of mitochondrial processes: a target for heart failure

scientific article published on January 2010

Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation

scientific article published on 16 June 2005

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

scientific article published on 20 January 2021

Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

scientific article

Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo

scientific article published on 24 May 2016

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice

scientific article published on 21 February 2013

Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway

scientific article

Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface

scientific article published on 27 June 2019

State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation

scientific article published on 3 February 2004

Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia

scientific article published on 7 February 2007

Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.

scientific article

Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats

scientific article

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities

scientific article

Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor

scientific article published on 10 April 2017

The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis

scientific article published on 19 February 2008

The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration

scientific article published on December 2016

The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins

scientific article published on 30 September 2002

The challenge in translating basic research discoveries to treatment of Huntington disease

scientific article published on 31 March 2014

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained

scientific article published on 7 May 2016

The many hats of protein kinase Cδ: one enzyme with many functions

scientific article

The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor ⬇️

scientific article published on August 15, 1995

The role of protein kinase C in cerebral ischemic and reperfusion injury

scientific article

Therapeutic potential for protein kinase C inhibitor in vascular restenosis

scientific article

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.

scientific article published on 17 October 2008

Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta

scientific article (publication date: October 2002)

Transcriptome analysis and prognosis of ALDH isoforms in human cancer

scientific article published on 9 February 2018

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury

scientific article published on 26 September 2016

Translational medicine: mitigating risks for investigators

scientific article published in May 2013

Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase

scientific article

deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification

scientific article published on 11 November 2009

deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart

scientific article

epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury

scientific article published on 27 May 2008

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C

scientific article published on September 8, 1992

β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways

scientific article

βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure

scientific article

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