Search filters

List of works by Jennifer Doudna

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

scientific article

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

scientific article published on October 2016

A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System ⬇️

scientific article published on 29 January 2019

A Higher Degree of Difficulty

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

scientific article

A Unified Resource for Tracking Anti-CRISPR Names

scientific article published on 01 October 2018

A bacterial Argonaute with noncanonical guide RNA specificity

scientific article published on 30 March 2016

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

scientific article

A conformational switch controls hepatitis delta virus ribozyme catalysis

scientific article

A fast and efficient procedure to produce scFvs specific for large macromolecular complexes

scientific article

A functional map of HIV-host interactions in primary human T cells

scientific article published on 01 April 2022

A general module for RNA crystallization ⬇️

scientific article published on June 12, 1998

A host of factors regulating influenza virus replication

scientific article

A magnesium ion core at the heart of a ribozyme domain

scientific article published on 01 July 1997

A molecular contortionist ⬇️

scientific article published on August 28, 1997

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis

scientific article published on 01 March 1991

A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes

scientific article

A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme

scientific article

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems

scientific article published on 30 June 2020

A sparse matrix approach to crystallizing ribozymes and RNA motifs

scientific article published on 01 January 1997

A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor

scientific article published on 01 November 1998

A thermostable Cas9 with increased lifetime in human plasma

scientific article

A thermostable Cas9 with increased lifetime in human plasma

A three-dimensional view of the molecular machinery of RNA interference

scientific article

A universal mode of helix packing in RNA.

scientific article

ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing

scientific article

ATP-independent diffusion of double-stranded RNA binding proteins ⬇️

scientific article published on December 18, 2012

Activating silent argonautes

scientific article

Adaptive strategies of the influenza virus polymerase for replication in humans

scientific article

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

scientific article published on 04 December 2020

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

scientific article

An essential GTPase promotes assembly of preribosomal RNA processing complexes

scientific article

An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase.

scientific article

An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer

scientific article

Analog sensitive chemical inhibition of the DEAD-box protein DDX3

scientific article published on 9 December 2015

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

scientific article

Applications of CRISPR technologies in research and beyond

scientific article

Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection

scientific article published on 13 June 2018

Assembly of an active group II intron-maturase complex by protein dimerization

scientific article published in June 2004

Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme

scientific article published on 01 March 1999

Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors

scientific article published on 01 April 2019

Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

scientific article published on 20 May 2020

Autoinhibition of human dicer by its internal helicase domain

scientific article

Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.

scientific article published on 23 November 2015

Biochemistry. Guided tour to the heart of RISC.

scientific article published in May 2012

Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering

scientific article

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

scientific article

Biotechnology: Rewriting a genome

scientific article published in March 2013

Blueprint for a Pop-up SARS-CoV-2 Testing Lab

scientific article published on 12 April 2020

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

scientific article published on 01 April 2019

CRISPR Immunological Memory Requires a Host Factor for Specificity

scientific article

CRISPR germline engineering--the community speaks

scientific article published on May 2015

CRISPR technology: A decade of genome editing is only the beginning

scientific article published on 19 January 2023

CRISPR's unwanted anniversary

scientific article published on 01 November 2019

CRISPR-Cas guides the future of genetic engineering

scientific article published in Science

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

scientific article published on 10 June 2020

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

scientific article published on 15 February 2018

CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification

scientific article published on 01 January 2019

CRISPR-Cas9 Structures and Mechanisms

scientific article

CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions

scientific article published on 01 January 2019

CRISPR-CasΦ from huge phages is a hypercompact genome editor

scientific article published on 01 July 2020

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing

scientific article

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

scientific article

Cancer-specific loss of <i>TERT</i> activation sensitizes glioblastoma to DNA damage

scientific article published on 01 March 2021

Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems

article

Cap-independent translation is required for starvation-induced differentiation in yeast

scientific article published in August 2007

Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

scientific article

Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling

scientific article published on 02 March 2020

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference

scientific article

CasX enzymes comprise a distinct family of RNA-guided genome editors

scientific article published on 04 February 2019

Cashing in on crystals

scientific article

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering

scientific article

Chemical biology at the crossroads of molecular structure and mechanism

scientific article

Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function

scientific article published on 01 October 1990

Chemistry of Class 1 CRISPR-Cas effectors: binding, editing, and regulation

scientific article published on 14 August 2020

Clades of huge phages from across Earth's ecosystems

scientific article published on 12 February 2020

Conformational control of DNA target cleavage by CRISPR-Cas9.

scientific article published on 28 October 2015

Conserved but nonessential interaction of SRP RNA with translation factor EF-G.

scientific article published on May 2004

Contributors

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

scientific article published on 09 May 2019

Controlling and enhancing CRISPR systems

scientific article published on 16 December 2020

Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing ⬇️

scientific article published on June 19, 2012

Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA.

scholarly article

Cornerstones of CRISPR-Cas in drug discovery and therapy

scientific article published on 23 December 2016

Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System

scientific article published on 6 April 2017

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

scientific article published on 17 April 2018

Corrigendum to "Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery" Acta Biomaterialia (2020), 114, 358-368

scientific article published on 09 December 2020

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

scientific article

Creative catalysis: pieces of the RNA world jigsaw ⬇️

scientific article published on December 1, 2001

Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning ⬇️

scientific article published on October 12, 2011

Crystal structure of a group I ribozyme domain: principles of RNA packing

scientific article

Crystal structure of a hepatitis delta virus ribozyme

scientific article

Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation

scientific article

Crystal structure of an RNA/DNA strand exchange junction

scientific article published on 18 April 2022

Crystal structure of the ribonucleoprotein core of the signal recognition particle

scientific article

Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module

scientific article published in January 2000

Crystallization of RNA and RNA-protein complexes

scientific article published in November 2004

Crystallization of ribozymes and small RNA motifs by a sparse matrix approach

scientific article

Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA

scientific article

Cutting it close: CRISPR-associated endoribonuclease structure and function

scientific article

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade

scientific article published on September 2016

DNA capture by a CRISPR-Cas9-guided adenine base editor

scientific article published on 01 July 2020

DNA interference states of the hypercompact CRISPR-CasΦ effector

scientific article published on 11 August 2021

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

scientific article

DNA recognition by an RNA-guided bacterial Argonaute

scientific article

Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

scientific article published on 07 March 2019

Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis

scientific article

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing ⬇️

scientific article published on May 9, 2013

Direct Link between RACK1 Function and Localization at the Ribosome In Vivo

scientific article

Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme

scientific article published in September 2001

Disabling Cas9 by an anti-CRISPR DNA mimic

scientific article

Disabling Cas9 by an anti-CRISPR DNA mimic

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

scientific article published on 01 September 2018

Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein

scientific article

Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron

scientific article

Dynamics of CRISPR-Cas9 genome interrogation in living cells

scientific article published on November 2015

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes.

scientific article

Emerging themes in RNA folding ⬇️

scientific article published on January 1, 1997

Engineering of Monosized Lipid-Coated Mesoporous Silica Nanoparticles for CRISPR Delivery

scientific article published on 20 July 2020

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

scientific article

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

scientific article published on 20 September 2017

Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules

scientific article published on 08 October 2013

Establishing suitability of RNA preparations for crystallization. Determination of polydispersity

scientific article published on 01 January 1997

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

scientific article

Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing

scientific article

Foreign DNA capture during CRISPR-Cas adaptive immunity

scientific article

Foreign DNA capture during CRISPR–Cas adaptive immunity

scientific article published in Nature

Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae

scientific article

Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3) ⬇️

scientific article published on December 20, 2011

GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis

scientific article published on 5 December 2005

Gene editing: CRISPR book review - Doudna responds

scientific article

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

scientific article

Genetic dissection of an RNA enzyme

scientific article published on 01 January 1987

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

scientific article

Genome editing: the end of the beginning

scientific article published on 23 December 2015

Genome-editing revolution: My whirlwind year with CRISPR.

scientific article

Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems

scientific article published on 25 January 2021

Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.

scientific article

Genomic engineering and the future of medicine

scientific article published on February 2015

Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome

scientific article

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

scientific article published on 11 September 2017

Hammerhead ribozyme structure: U-turn for RNA structural biology ⬇️

scientific article published on August 15, 1995

Hammering out the shape of a ribozyme

scientific article published on 01 December 1994

Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery ⬇️

scientific article published on June 19, 2013

Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit

scientific article (publication date: 9 March 2001)

Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding

scientific article

High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity

High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding

scientific article

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity ⬇️

scientific article published on August 11, 2013

Huge and variable diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems

scientific article published on 15 May 2020

Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities

scientific article published on 02 January 2021

IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2

scientific article published on 11 December 2020

Identification and analysis of U5 snRNA variants in Drosophila

scientific article published in October 2005

In vitro reconstitution of the human RISC-loading complex

scientific article

In vivo human T cell engineering with enveloped delivery vehicles

scientific article published in 2024

Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.

scientific article published on 26 June 2019

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

scientific article published on 12 October 2016

Insights into RNA structure and function from genome-wide studies

scientific article published on 13 May 2014

Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity

scientific article

Jennifer Doudna: We can now edit our DNA. But let's do it wisely

TEDGlobal>London

Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain

scientific article published on 03 August 2018

Knocking out barriers to engineered cell activity

scientific article published on 06 February 2020

Large-scale purification of a stable form of recombinant tobacco etch virus protease

scientific article published in March 2001

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

scientific article published in July 2022

Machine learning predicts new anti-CRISPR proteins

scientific article published on 14 April 2020

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

scientific article

Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes

scientific article

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3

scientific article

Massively parallel kinetic profiling of natural and engineered CRISPR nucleases

scientific article published on 07 September 2020

Massively parallel kinetic profiling of natural and engineered CRISPR nucleases

scientific article published on 9 July 2019

Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

scientific article

Mechanism of ribosome recruitment by hepatitis C IRES RNA

scientific article

Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

scientific article published on 16 February 2012

Mechanisms of internal ribosome entry in translation initiation

scientific article

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

scientific article published on 05 April 2016

Metal ions in ribozyme folding and catalysis

scientific article

Metal-binding sites in the major groove of a large ribozyme domain

scientific article

Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface

scientific article published in January 2014

Methods to crystallize RNA.

scientific article published on May 2001

Miniribozymes, small derivatives of the sunY intron, are catalytically active

scientific article published on December 1989

Modeling and automation of sequencing-based characterization of RNA structure

scientific article

Molecular Mechanisms of RNA Interference ⬇️

scientific article published on January 1, 2013

Molecular mechanism of off-target effects in CRISPR-Cas9

scientific article

Multiple sensors ensure guide strand selection in human RNAi pathways

scientific article published on 26 March 2013

Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)

scientific article

Mutational analysis of conserved nucleotides in a self-splicing group I intron

scientific article published on 01 October 1990

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response

scientific article

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA induces homology-directed DNA repair

article published in 2017

Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa

scientific article

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

scientific article published on 18 March 2022

New CRISPR-Cas systems from uncultivated microbes.

scientific article

New tools provide a second look at HDV ribozyme structure, dynamics and cleavage

scientific article

Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules

scientific article published on 28 March 2019

Nucleic acids and their protein partners

scientific article published on 09 June 2008

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

scientific article published on 28 April 2016

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

scientific article

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

scientific article published on 19 July 2022

Optimized High-Throughput Screen for Hepatitis C Virus Translation Inhibitors ⬇️

scientific article published on February 1, 2011

Paul Sigler (1934-2000).

scientific article published in May 2000

Perspective: Embryo editing needs scrutiny

scientific article

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

scientific article published on 16 March 2020

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

scientific article published on 10 March 2020

Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions ⬇️

scientific article published on 09 August 2013

Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase

scientific article published on 01 September 1996

Preparation of homogeneous ribozyme RNA for crystallization

scientific article published on 01 January 1997

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

scientific article

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

scientific article

Programmable RNA recognition and cleavage by CRISPR/Cas9.

scientific article

Programmable RNA recognition using a CRISPR-associated Argonaute

scientific article published on 12 March 2018

Programmable RNA recognition using a CRISPR-associated Argonaute

scientific article published on 23 October 2017

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

scientific article published in Science

Protecting genome integrity during CRISPR immune adaptation

scientific article published on 5 September 2016

Quantitative studies of ribosome conformational dynamics

scientific article published on May 2007

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a

scientific article published on 01 July 2018

RNA Scanning of a Molecular Machine with a Built-in Ruler

scientific article

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

scientific article

RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System

scientific article

RNA binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a

RNA folds: insights from recent crystal structures

scientific article (publication date: 1999)

RNA processing enables predictable programming of gene expression

scientific article published on 16 September 2012

RNA seeing double: Close-packing of helices in RNA tertiary structure ⬇️

scientific article published on July 1, 1997

RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron

scientific article

RNA structure: crystal clear?

scientific article published on June 1997

RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus

scientific article

RNA tertiary structure mediation by adenosine platforms

scientific article

RNA-based recognition and targeting: sowing the seeds of specificity

scientific article published on 15 February 2017

RNA-catalysed synthesis of complementary-strand RNA

scientific article published in Nature

RNA-dependent RNA targeting by CRISPR-Cas9.

scientific article

RNA-guided assembly of Rev-RRE nuclear export complexes

scientific article

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions ⬇️

scientific article published on May 2, 2011

RNA-guided genetic silencing systems in bacteria and archaea ⬇️

scientific article (publication date: 15 February 2012)

RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle.

scientific article published on 20 November 2005

RNA-programmed genome editing in human cells

scientific article (publication date: 29 January 2013)

RNA-protein analysis using a conditional CRISPR nuclease

scientific article published on 14 March 2013

RNA: primed for packing?

scientific article

RNAs regulate biology

scientific article published in July 2006

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

scientific article

Rapid detection of SARS-CoV-2 with Cas13

scientific article published on 16 December 2020

Rational design of a split-Cas9 enzyme complex

scientific article

Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing

scientific article published on 01 October 2020

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.

scientific article published on 14 September 2016

Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers

scientific article

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing.

scientific article published on 18 April 2018

Reconsidering Movement of Eukaryotic mRNAs between Polysomes and P Bodies ⬇️

scientific article published on December 9, 2011

Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

scientific article published on 25 June 2016

Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules

scientific article published on 29 October 2019

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

scientific article (publication date: 28 February 2013)

Ribonuclease revisited: structural insights into ribonuclease III family enzymes

scientific article (publication date: February 2007)

Ribozyme catalysis: not different, just worse

scientific article

Ribozyme structures and mechanisms

scientific article (publication date: 2001)

Ribozyme structures and mechanisms

scientific article

Ribozyme-catalyzed primer extension by trinucleotides: A model for the RNA-catalyzed replication of RNA ⬇️

scientific article published on March 2, 1993

Ribozymes: The hammerhead swings into action ⬇️

scientific article published on 01 July 1998

Ro's role in RNA reconnaissance

scientific article

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting

scientific article

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

scientific article

Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor

scientific article

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

scientific article

Self-assembly of a group I intron active site from its component tertiary structural domains.

scientific article

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

scientific article

Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes

scientific article

Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation

scientific article published on 21 August 2020

Site-Specific Generation of Protein-Protein Conjugates Using Native Amino Acids

Solving large RNA structures by X-ray crystallography

scientific article published on 01 January 2000

Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response

scientific article published on 29 January 2019

Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove

scientific article

Specificity of RNA-RNA helix recognition

scientific article

Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna

scientific article published in February 2018

Stereochemical course of catalysis by the Tetrahymena ribozyme

scientific article

Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity

scientific article

Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle

scientific article

Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly

scientific article

Structural and mechanistic insights into hepatitis C viral translation initiation

scientific article

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

scientific article published on 09 August 2019

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

scientific article

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense

scientific article

Structural basis for double-stranded RNA processing by Dicer

scientific article

Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

scientific article

Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry

scientific article

Structural determinants of RNA recognition and cleavage by Dicer

scientific article published on 16 September 2007

Structural genomics of RNA.

scientific article published in November 2000

Structural insights into RNA interference

scientific article

Structural insights into RNA processing by the human RISC-loading complex

scientific article

Structural insights into group II intron catalysis and branch-site selection

scientific article

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

scientific article

Structural insights into the signal recognition particle

scientific article published on January 2004

Structural roles for human translation factor eIF3 in initiation of protein synthesis

scientific article

Structural roles of monovalent cations in the HDV ribozyme

scientific article

Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

scientific article published in October 2013

Structure and function of the eukaryotic ribosome: the next frontier

scientific article published in April 2002

Structure of Dicer and mechanistic implications for RNAi

scientific article

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity ⬇️

scientific article published on May 23, 2013

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

scientific article

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

scientific article

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

scientific article

Structures of the CRISPR genome integration complex

scientific article

Structures of the RNA-guided surveillance complex from a bacterial immune system

scientific article

Substrate-specific kinetics of Dicer-catalyzed RNA processing

scientific article

Substrate-specific structural rearrangements of human Dicer

scientific article published on 28 April 2013

Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

scientific article

Systematic discovery of natural CRISPR-Cas12a inhibitors

scientific article

TRBP alters human precursor microRNA processing in vitro

scientific article

Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

scientific article published on 05 July 2019

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

scientific article

Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli

scientific article published in 2014

Temperature-Responsive Competitive Inhibition of CRISPR-Cas9

scientific article published on 27 December 2018

Template-directed primer extension catalyzed by the Tetrahymena ribozyme

scientific article published on June 1991

Tertiary Motifs in RNA Structure and Folding

scientific article

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor ⬇️

scientific article published on February 18, 2011

The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit

scientific article

The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core

scientific article published on 01 March 1997

The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis

scientific article published on March 2000

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders

article by A Jeremy Willsey et al published 26 July 2018 in Cell

The chemical repertoire of natural ribozymes

scientific article

The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold

scientific article published in September 1999

The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro

scientific article

The parallel universe of RNA folding

scientific article published on 01 May 1998

The pathway of hepatitis C virus mRNA recruitment to the human ribosome

scientific article (publication date: April 2009)

The promise and challenge of therapeutic genome editing

scientific article published on 12 February 2020

The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs

scientific article published on January 2001

The structural biology of CRISPR-Cas systems

scientific article published on 24 February 2015

Tunable protein synthesis by transcript isoforms in human cells

scientific article

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation ⬇️

scientific article published on June 13, 2013

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

scientific article published on 26 September 2016

Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure ⬇️

scientific article published on February 14, 2013

Use of cis- and trans-ribozymes to remove 5' and 3' heterogeneities from milligrams of in vitro transcribed RNA.

scientific article published on March 1996

Voices of biotech

scientific article published on March 2016

Widespread Translational Remodeling during Human Neuronal Differentiation

scientific article

dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants

scientific article published on 22 January 2009

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation

scientific journal article

eIF3j is located in the decoding center of the human 40S ribosomal subunit

scientific article

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes ⬇️

scientific article published on July 8, 2011

Paulina is supported by:

About Paulina

Help