Search filters

List of works by Ted M. Dawson

37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake

scientific article

A Lysosomal Lair for a Pathogenic Protein Pair ⬇️

scientific article published on July 13, 2011

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

scientific article published on December 2003

A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

scientific article published in October 2002

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

scientific article

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit

scientific article published on May 2014

Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes

scientific article published on January 2014

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

scientific article published on September 2009

Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease

scientific article

Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease

scientific article published in March 2005

Activation mechanisms of the E3 ubiquitin ligase parkin

scientific article published on 30 August 2017

Advances in neuronal cell death 2007.

scientific article published on 10 January 2008

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

scientific article

Alpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

scholarly article by Daniela Berg et al published 2005 in Movement Disorders

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

scientific article

Animal models of PD: pieces of the same puzzle?

scientific article

Animal models of Parkinson's disease: vertebrate genetics

scientific article

Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease

scientific article

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

scientific article

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

scientific article

Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.

scientific article published in December 2004

ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2 ⬇️

scientific article published on March 14, 2012

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

scientific article

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease

scientific article published on 29 August 2016

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

scientific article published on 11 April 2007

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis

scientific article published on 5 July 2016

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

scientific article published on 23 May 2008

BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development

scientific article published in April 2003

Bcl-x is required for proper development of the mouse substantia nigra.

scientific article published in July 2005

C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies

scientific article published on 31 May 2016

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

scientific article (publication date: April 2004)

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

scholarly article

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos).

scientific article published on 13 May 2009

Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

scientific article published on October 2003

Cell Death Mechanisms of Neurodegeneration

scientific article published in January 2017

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

scientific article published on 10 August 2011

Cognitive profile of LRRK2-related Parkinson's disease

scientific article

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

scientific article published on 24 July 2009

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

scientific article

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation.

scientific article

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

scientific article

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

scientific article published on April 2016

DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.

scientific article

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

scientific journal article

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy ⬇️

scientific article published on November 14, 2012

Diagnosis and treatment of Parkinson disease: molecules to medicine

scientific article

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

scientific article

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

scientific article published on 13 February 2018

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation--clinical and functional study

scientific article

Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia

scientific article

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

scientific article published on 20 October 2005

Erratum: T cells from patients with Parkinson's disease recognize α-synuclein peptides

scientific article published in September 2017

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

scientific article published on 13 November 2006

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

scientific article

Failures and successes of clinical trials for Parkinson disease treatments

scientific article

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

scientific article published on 27 July 2005

Functional Identification of Neuroprotective Molecules ⬇️

scientific article published on November 24, 2010

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

scientific article

GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease

scientific article

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

scientific article published on 8 January 2018

GTPase activity plays a key role in the pathobiology of LRRK2.

scientific article

Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients

scientific article

Genetic analysis of neurodegenerative diseases in a pathology cohort

Genetic animal models of Parkinson's disease

scientific article published on June 2010

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder

scientific article published on 15 September 2014

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

scientific article

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

scientific article

Identification and analysis of plasticity-induced late-response genes

scientific article published on 6 February 2004

Identification and evaluation of NO-regulated genes by differential analysis of primary cDNA library expression (DAzLE).

scientific article published in January 2005

Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).

scientific article published on 30 December 2003

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

scientific article (publication date: 16 June 2006)

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage ⬇️

scientific article published on August 8, 2011

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

scientific article published on 22 May 2011

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

article

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models ⬇️

scientific article published on July 18, 2011

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease ⬇️

scientific article published on August 22, 2010

Ironing out tau's role in parkinsonism ⬇️

scientific article published on February 6, 2012

Kinase activity of mutant LRRK2 mediates neuronal toxicity

scientific article

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease ⬇️

scientific article published on October 1, 2012

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

scientific article

LRRK2 pathobiology in Parkinson's disease

scientific article published on 10 October 2014

LRRK2 pathobiology in Parkinson's disease - virtual inclusion

scientific article published on 22 February 2016

Lessons from Drosophila models of DJ-1 deficiency

scientific article

Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

scientific article published on 09 May 2012

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

scientific article

Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions

scientific article published on July 2009

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

scientific article

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

scientific article

Loss of locus coeruleus neurons and reduced startle in parkin null mice

scientific article

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

scientific article published on November 2007

Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity

scientific article published on 2 December 2015

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

scientific article

Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease

scientific article published on January 2012

Mediation of cell death by poly(ADP-ribose) polymerase-1.

scientific article

Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

scientific article

MiR-223 regulates the differentiation of immature neurons

scientific article

MicroRNA-223 is neuroprotective by targeting glutamate receptors ⬇️

scientific article published on October 29, 2012

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

scholarly article by Tatsuya Yamada published in October 2018

Mitochondrial and nuclear cross talk in cell death: parthanatos

scientific article published on December 2008

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

scientific article

Models of LRRK2-Associated Parkinson's Disease

scientific article published on January 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Molecular pathophysiology of Parkinson's disease

scientific article

Morphometry of the human substantia nigra in ageing and Parkinson's disease

scientific article published on 23 February 2008

Motor neuron death in ALS: programmed by astrocytes?

scientific article published on March 2014

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

scientific article

NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice

scientific article

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

scientific article

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease

scientific article published on 17 July 2009

Neuronal activity regulates hippocampal miRNA expression

scientific article (publication date: 2011)

Neuroprotection by pharmacologic blockade of the GAPDH death cascade

scientific article

Neuroprotective and neurorestorative strategies for Parkinson's disease

scientific article

Neurotoxic reactive astrocytes are induced by activated microglia

scientific article

Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons

scientific article published on August 2005

New insights into Parkinson’s disease ⬇️

scientific article published on October 1, 2003

New synaptic and molecular targets for neuroprotection in Parkinson's disease

scientific article published on 23 August 2012

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies

scientific article published on 13 June 2016

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

scientific article

Non-autonomous cell death in Parkinson's disease

scientific article published on June 2008

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

scientific article

Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

scientific article published on May 2004

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

scientific journal article

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

scientific article published on 18 February 2017

Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release

scientific article

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

scientific article

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease

scientific article

PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury

scientific article published in September 2004

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

scientific article

Parkin and Hsp70 sacked by BAG5.

scientific article

Parkin and Neurodegeneration

Parkin and Neurodegeneration

Parkin and PINK1: much more than mitophagy

scientific article published on 13 April 2014

Parkin blushed by PINK1.

scientific article

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

scientific article

Parkin mediates the degradation-independent ubiquitination of Hsp70

scientific article published on February 2008

Parkin plays a role in sporadic Parkinson's disease

scientific article published on 11 September 2013

Parkin-associated Parkinson's disease

scientific article published on 30 July 2004

Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

scientific article

Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

scientific article

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program

scientific article published on 23 June 2017

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death

scientific article

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

scientific article

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

scientific article

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

scientific article

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

scientific article published on April 2014

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

scientific article

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

scientific article

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1–Dependent Cell Death (Parthanatos) ⬇️

scientific article published on April 5, 2011

Poly(ADP-ribose) (PAR) polymer is a death signal

scholarly article

Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery

scientific article published in April 2002

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

scientific article published on December 2003

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

scientific article

Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos

scientific article published on 28 March 2009

Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1.

scientific article

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

scientific article

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

scientific article

Recent advances in the genetics of Parkinson's disease

scientific article

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

scientific article

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

scientific article published on 28 February 2007

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder

scientific article

Reprogramming cellular events by poly(ADP-ribose)-binding proteins ⬇️

scientific article published on December 23, 2012

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

scientific article

Revelations and revolutions in the understanding of Parkinson's disease.

scientific article

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

scientific article

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

scientific article published on 31 January 2018

Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses

scientific article published on January 2003

Role of nitric oxide in Parkinson's disease

scientific article

Role of tuberin in neuronal degeneration

scientific article published on 5 March 2008

S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

scientific article

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

scholarly article

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

scientific article

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease

scientific article published on 9 February 2018

SnapShot: pathogenesis of Parkinson's disease

scientific article published in October 2009

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

scientific article published on 8 November 2005

Sulfhydration mediates neuroprotective actions of parkin

scientific article published on January 2013

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

scientific article

T cells from patients with Parkinson's disease recognize α-synuclein peptides

scientific article

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF.

scientific article published on 21 October 2015

The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

scientific article

The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior

scientific journal article

The AAA + ATPase Thorase is neuroprotective against ischemic injury

scientific article published in January 2018

The NINDS Parkinson's disease biomarkers program

scientific article published on 7 October 2015

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

scientific article

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

scientific article published on 2 May 2014

The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects

scientific article

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

The impact of genetic research on our understanding of Parkinson's disease

scientific article published on January 2010

The interplay of microRNA and neuronal activity in health and disease

scientific article published on 27 August 2013

The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice

scientific article published in July 2005

The orphan nuclear receptor, steroidogenic factor 1, regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes

scientific article published on December 2002

The road to survival goes through PARG.

scientific article

The role of parkin in familial and sporadic Parkinson's disease

scientific article published on January 2010

The role of stem cells in Parkinson's disease

scientific article published on January 2007

To die or grow: Parkinson's disease and cancer

scientific article

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity ⬇️

scientific article published on October 4, 2011

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes

scientific article

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

scientific article published on 07 June 2016

Understanding microRNAs in neurodegeneration

scientific article

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

scientific article

Unraveling the role of defective genes in Parkinson's disease

scientific article published on January 2007

Usp16: key controller of stem cells in Down syndrome

scientific article published on 27 September 2013

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

scientific article

What causes cell death in Parkinson's disease?

scientific article published on December 2008

What have genetically engineered mice taught us about ischemic injury?

scientific article published on March 2004

c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential

scientific article published in January 2017

Paulina is supported by:

About Paulina

Help