List of works - Milton T Stubbs

2.7 Å cryo-EM structure of vitrified M. musculus H-chain apoferritin from a compact 200 keV cryo-microscope

scientific article published on 06 May 2020

3-Amidinophenylalanine-based inhibitors of urokinase

scientific article

A model for the specificity of fibrinogen cleavage by thrombin.

scientific article

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase

scientific article

A player of many parts: the spotlight falls on thrombin's structure.

scientific article

Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein

scientific article

Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains

scientific article published on 07 February 2007

Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions

scientific article

An active zymogen: unravelling the mystery of tissue-type plasminogen activator.

scientific article published on February 1998

Anthrax X-rayed: new opportunities for biodefence.

scientific article

Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms

scientific article

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage

scientific article

Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C

scientific article published on 01 July 1997

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues

scientific article

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29

scientific article

Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus

scientific article

Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis

scientific article

Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

scientific article

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

scientific article published on 13 November 1995

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs

scientific article

Crystal structures of the membrane-binding C2 domain of human coagulation factor V

scientific article

Crystallization and preliminary X-ray analysis of the matrix protein of Borna disease virus.

scientific article published on 20 July 2002

Crystallization of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster

scientific article

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

scientific article published in April 2004

Crystals of the NC1 domain of human type IV collagen

scientific article published on 01 February 1990

Cystatins as calpain inhibitors: engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of mu-calpain.

scientific article published in January 2001

Deadenylation-a piece of PANcake

scientific article published on 23 June 2014

Design of benzamidine-type inhibitors of factor Xa

scientific article published on 01 October 1998

Disulfide linkage and structure of highly stable yeast-derived virus-like particles of murine polyomavirus

scientific article

Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals.

scientific article published on 11 May 2012

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

scientific article

Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

scientific article

Functional and Structural Characterization of a Cation-dependent O-Methyltransferase from the Cyanobacterium Synechocystis sp. Strain PCC 6803

scientific article

Hairpin loop mutations of chicken cystatin have different effects on the inhibition of cathepsin B, cathepsin L and papain ⬇️

scientific article published on March 20, 1995

High-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms

scientific article

Highlight: Conformational transitions in macromolecular interactions

scientific article published on 01 July 2014

Impact of the C-terminal disulfide bond on the folding and stability of onconase

scientific article

In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain

scientific article

Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus

scientific article

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis

scientific article published on 05 January 2021

Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase

scientific article

Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment

scientific article

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity

scientific article

N-terminal protein modification by substrate-activated reverse proteolysis

scientific article

Nonaromatic Sulfonamide Group as an Ideal Anchor for Potent Human Carbonic Anhydrase Inhibitors: Role of Hydrogen-Bonding Networks in Ligand Binding and Drug Design

scientific article published on 01 August 2002

Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity.

scientific article published on April 2003

Outward open conformation of a Major Facilitator Superfamily multidrug/H antiporter provides insights into switching mechanism

scientific article published in Nature Communications

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

scientific article

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46

scientific article

Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity

scientific article

Sinapoyltransferases in the light of molecular evolution.

scientific article

Spatial structure of thrombin as a guide to its multiple sites of interaction.

scientific article

Structural and energetic determinants for enantiopreferences in kinetic resolution of lipases

scientific article published on 01 May 2003

Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

scientific article published on December 1998

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy

scientific article published on 16 June 2017

Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

scientific article

Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein

scientific article

Structure and specificity in coagulation and its inhibition

scientific article published on 01 July 1995

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity

scientific article

Structure-based Design of a Potent Chimeric Thrombin Inhibitor ⬇️

scientific article published on August 8, 1997

Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus

scientific article

Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond

scientific article published on 01 March 1995

The clot thickens: clues provided by thrombin structure.

scientific article published on January 1995

The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs

scientific article

The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis

scientific article published on 20 June 2017

The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa

scientific article

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

scientific article

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

scientific article published on June 1997

Thermodynamic signatures in macromolecular interactions involving conformational flexibility

scientific article

Trypsin mutants for structure-based drug design: expression, refolding and crystallisation.

scientific article published on July 2002

Understanding protein-ligand interactions: the price of protein flexibility

scientific article

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

scientific article (publication date: 27 March 2003)

ZZ made EZ: influence of inhibitor configuration on enzyme selectivity.

scientific article published in July 2003

exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: syntheses and nicotinic acetylcholine receptor agonist activity of potent pyridazine analogues of (+/-)-epibatidine.

scientific article

List of works by Milton T Stubbs

2.7 Å cryo-EM structure of vitrified M. musculus H-chain apoferritin from a compact 200 keV cryo-microscope

3-Amidinophenylalanine-based inhibitors of urokinase

A model for the specificity of fibrinogen cleavage by thrombin.

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase

A player of many parts: the spotlight falls on thrombin's structure.

Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein

Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains

Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions

An active zymogen: unravelling the mystery of tissue-type plasminogen activator.

Anthrax X-rayed: new opportunities for biodefence.

Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage

Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29

Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus

Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis

Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs

Crystal structures of the membrane-binding C2 domain of human coagulation factor V

Crystallization and preliminary X-ray analysis of the matrix protein of Borna disease virus.

Crystallization of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening

Crystals of the NC1 domain of human type IV collagen

Cystatins as calpain inhibitors: engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of mu-calpain.

Deadenylation-a piece of PANcake

Design of benzamidine-type inhibitors of factor Xa

Disulfide linkage and structure of highly stable yeast-derived virus-like particles of murine polyomavirus

Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals.

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design

Functional and Structural Characterization of a Cation-dependent O-Methyltransferase from the Cyanobacterium Synechocystis sp. Strain PCC 6803

Hairpin loop mutations of chicken cystatin have different effects on the inhibition of cathepsin B, cathepsin L and papain ⬇️

High-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms

Highlight: Conformational transitions in macromolecular interactions

Impact of the C-terminal disulfide bond on the folding and stability of onconase

In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain

Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis

Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase

Molecular basis of -amyloid oligomer recognition with a conformational antibody fragment

Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity

N-terminal protein modification by substrate-activated reverse proteolysis

Nonaromatic Sulfonamide Group as an Ideal Anchor for Potent Human Carbonic Anhydrase Inhibitors: Role of Hydrogen-Bonding Networks in Ligand Binding and Drug Design

Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity.

Outward open conformation of a Major Facilitator Superfamily multidrug/H antiporter provides insights into switching mechanism

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46

Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity

Sinapoyltransferases in the light of molecular evolution.

Spatial structure of thrombin as a guide to its multiple sites of interaction.

Structural and energetic determinants for enantiopreferences in kinetic resolution of lipases

Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy

Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein

Structure and specificity in coagulation and its inhibition

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity

Structure-based Design of a Potent Chimeric Thrombin Inhibitor ⬇️

Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus

Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond

The clot thickens: clues provided by thrombin structure.

The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs

The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis

The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

Thermodynamic signatures in macromolecular interactions involving conformational flexibility

Trypsin mutants for structure-based drug design: expression, refolding and crystallisation.

Understanding protein-ligand interactions: the price of protein flexibility

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis

ZZ made EZ: influence of inhibitor configuration on enzyme selectivity.

exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: syntheses and nicotinic acetylcholine receptor agonist activity of potent pyridazine analogues of (+/-)-epibatidine.