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List of works by Nikolai O. Artemyev

A GPR-protein interaction surface of Gi(alpha): implications for the mechanism of GDP-release inhibition.

scientific article published in January 2002

A conformational switch in the inhibitory gamma-subunit of PDE6 upon enzyme activation by transducin.

scientific article published in November 2001

A nonhuman primate model of inherited retinal disease

scientific article published on 22 January 2019

A point mutation uncouples transducin-alpha from the photoreceptor RGS and effector proteins.

scientific article published in December 2003

A single mutation Asp229 --> Ser confers upon Gs alpha the ability to interact with regulators of G protein signaling

scientific article published on 01 September 1998

A site on rod G protein alpha subunit that mediates effector activation

scientific article published on 01 May 1992

A truncated form of rod photoreceptor PDE6 β-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the γ-subunit

scientific article

AIPL1: A specialized chaperone for the phototransduction effector.

scientific article

Active sites of the cyclic GMP phosphodiesterase gamma-subunit of retinal rod outer segments

scientific article published on 01 July 1988

An interface of interaction between photoreceptor cGMP phosphodiesterase catalytic subunits and inhibitory gamma subunits.

scientific article

Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client

scientific article published on 7 June 2016

Assays of G protein/cGMP-phosphodiesterase interactions

scientific article published on 01 January 2002

Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing.

scientific article published on 4 February 2012

Chaperones and retinal disorders

scientific article published on 28 November 2018

Characterization of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods

scientific article published on 28 September 2009

Comparative analysis of cone and rod transducins using chimeric Gα subunits.

scientific article published on 16 February 2012

Coupling between the N- and C-terminal domains influences transducin-alpha intrinsic GDP/GTP exchange

scientific article published on 01 April 2000

Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia

scientific article published on December 2010

Determinants for phosphodiesterase 6 inhibition by its gamma-subunit

scientific article

Diffusion and light-dependent compartmentalization of transducin.

scientific article

Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains.

scientific article published in March 2002

Distinct patterns of compartmentalization and proteolytic stability of PDE6C mutants linked to achromatopsia.

scientific article

Dominant negative mutants of transducin-alpha that block activated receptor.

scientific article published on May 2006

Dysregulation of Ca(v)1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2

scientific article

Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice

scientific article published in January 2018

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.

scientific article published on June 2015

Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors

scientific article

Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.

scientific article

Heterologous expression of bovine rhodopsin in Drosophila photoreceptor cells.

scientific article published in September 2006

Identification of effector residues on photoreceptor G protein, transducin.

scientific article

Identification of the gamma subunit-interacting residues on photoreceptor cGMP phosphodiesterase, PDE6alpha '

scientific article published on 01 December 2000

Interaction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moiety

scientific article published on 04 June 2013

Interaction of human retinal RGS with G-protein alpha-subunits

scientific article (publication date: 14 July 1997)

Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory Pγ subunit of phosphodiesterase 6

scientific article published on 05 September 2019

Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.

scientific article

Large-scale conformational rearrangement of the α5-helix of Gα subunits in complex with the guanine nucleotide exchange factor Ric8A

scientific article published on 17 October 2019

Light-dependent compartmentalization of transducin in rod photoreceptors.

scientific article

Loss of the Effector Function in a Transducin-α Mutant Associated with Nougaret Night Blindness

scientific article published in Journal of Biological Chemistry

Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma-subunits

scientific article published on May 1996

Mechanisms of dominant negative G-protein alpha subunits.

scientific article published on December 2007

Mechanisms of mutant PDE6 proteins underlying retinal diseases.

scientific article published on 2 June 2017

Modulation of transducin GTPase activity by chimeric RGS16 and RGS9 regulators of G protein signaling and the effector molecule

scientific article published on 01 April 1999

Mutational analysis of the Asn residue essential for RGS protein binding to G-proteins

scientific article published on 01 March 1998

N-terminal fatty acylation of transducin profoundly influences its localization and the kinetics of photoresponse in rods

scientific journal article

NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand.

scientific article published on 24 February 2017

NMR resonance assignments of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)

scientific article published on 19 October 2018

PDE6 in lamprey Petromyzon marinus: implications for the evolution of the visual effector in vertebrates

scientific article

Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia.

scientific article

Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits

scientific article published on 01 January 1998

Phototransduction in a transgenic mouse model of Nougaret night blindness

scientific article published on 01 June 2006

Probing G-protein function

scientific article published on 01 November 1994

Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase.

scientific article published on September 1998

Probing functional interfaces of rod PDE gamma-subunit using scanning fluorescent labeling

scientific article published on 01 January 1998

Probing rhodopsin-transducin interaction using Drosophila Rh1-bovine rhodopsin chimeras.

scientific article published on 18 September 2006

Probing the mechanism of rhodopsin-catalyzed transducin activation.

scientific article

Regulation of Transducin GTPase Activity by Human Retinal RGS ⬇️

scientific article published on July 11, 1997

Rhodopsin recognition by mutant G(s)alpha containing C-terminal residues of transducin

scientific article published on 01 January 2000

Ric-8A, a GEF, and a Chaperone for G Protein α-Subunits: Evidence for the Two-Faced Interface

scientific article published on 22 January 2020

Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent.

scientific article

Roles of the transducin alpha-subunit alpha4-helix/alpha4-beta6 loop in the receptor and effector interactions

scientific article published on 01 March 1999

Specific peptide probes for G-protein interaction with effectors

scientific article published on 01 January 1994

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

scientific article

Structural determinants of the PDE6 GAF A domain for binding the inhibitory gamma-subunit and noncatalytic cGMP

scientific article published on 01 January 2004

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

scientific article published on 12 July 2019

Substitution of transducin ser202 by asp abolishes G-protein/RGS interaction

scientific article published on 01 February 1998

Subunit structure of rod cGMP-phosphodiesterase

scientific article published on 01 October 1996

The Drosophila rhodopsin cytoplasmic tail domain is required for maintenance of rhabdomere structure.

scientific article published on 11 December 2006

The GAFa domain of phosphodiesterase-6 contains a rod outer segment localization signal.

scientific article

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

scientific article published in Journal of Biological Chemistry

The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site

scientific article published on 01 May 1997

The solution structure of the transducin-α-uncoordinated 119 protein complex suggests occlusion of the Gβ₁γ₁-binding sites

scientific article

The trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes.

scientific article published on March 2000

Transducin activation state controls its light-dependent translocation in rod photoreceptors.

scientific article

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase ⬇️

scientific article published on April 1, 1992

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

scientific article published on 24 July 2017

Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus.

scientific article published on 22 August 2008

α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.

scientific article published on 6 June 2018

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