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List of works by Evette S. Radisky

A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering

scientific article published in Journal of Biological Chemistry

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis

scientific article

Bad Tumors Made Worse: SPINK1

scientific article published on 04 February 2019

Biochemical and structural insights into mesotrypsin: an unusual human trypsin.

scientific article published on 13 September 2013

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

scientific article published on 10 August 2018

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy

scientific article

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.

scientific article published on 23 February 2018

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

scientific article published on 13 January 2017

Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition

scientific article published on 30 April 2019

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

scientific article published on 30 January 2019

EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review

scientific article

Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies

scientific article published on 01 August 1999

Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes

scientific article

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues

scientific article

Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis

scientific article published on 07 January 2009

Identifying the Stroma as a Critical Player in Radiation-Induced Mammary Tumor Development ⬇️

scientific article published on May 17, 2011

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

scientific article

MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer

scientific article published on 13 April 2016

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

scientific article published in Nature Communications

Mapping recombinant events with molecular markers in hemochromatosis pedigrees

scientific article published on 01 January 1994

Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTURE

scientific article

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

scientific article

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

scientific article

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

scientific article

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates

scientific article

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

scientific article

Novel Pathogenic Variant p.Glu190Lys in a Case of Chronic Pancreatitis

scientific article published on 06 February 2019

PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) ⬇️

scientific article published on November 20, 2012

PRSS3/Mesotrypsin Is a Therapeutic Target for Metastatic Prostate Cancer ⬇️

scientific article published on December 1, 2012

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

scientific article published in Scientific Reports

Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

scientific article published on 13 March 2018

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors

scientific article

Quantitative Mapping of Binding Specificity Landscapes for Homologous Targets by using a High‑Throughput Method

scientific article published on 15 April 2020

Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2.

scientific article published in May 2005

Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

scientific article

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers

scientific article published on 30 September 2015

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

scientific article

Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies.

scientific article published in February 2000

TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure.

scientific article published on 27 March 2013

Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

scientific article published on 14 September 2020

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

scientific article

The P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity

scientific article

The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin

scientific article

The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver

scientific journal article

The role of the protein core in the inhibitory power of the classic serine protease inhibitor, chymotrypsin inhibitor 2.

scientific article

Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma

scientific article

Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma

scientific article

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

scientific article

Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.

scientific article

Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda

scientific article

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.

scientific article published on 08 January 2014

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