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List of works by Christopher R Pudney

A complete thermodynamic analysis of enzyme turnover links the free energy landscape to enzyme catalysis

scholarly article

An excitation-energy-dependent molecular beacon detects early-stage neurotoxic Aβ aggregates in the presence of cortical neurons

scientific article published on 21 November 2018

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

scientific article published on 01 January 2008

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

scientific article published on February 2008

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

scientific article published in January 2009

Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme

scientific article

Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase

scientific article published on 31 July 2009

Change in heat capacity accurately predicts vibrational coupling in enzyme catalyzed reactions

scientific article published on 11 July 2015

Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation

scientific article

Coupled motions direct electrons along human microsomal P450 Chains

scientific article

Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions

scientific article published on August 2010

Enzymatic Single-Molecule Kinetic Isotope Effects

scientific article published on 19 February 2013

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction

scientific article

Excited state dynamics can be used to probe donor-acceptor distances for H-tunneling reactions catalyzed by flavoproteins

scientific article published on December 2013

Exposing the Interplay Between Enzyme Turnover, Protein Dynamics, and the Membrane Environment in Monoamine Oxidase B

scientific article published on 23 April 2019

Fast protein motions are coupled to enzyme H-transfer reactions

scientific article published on 11 February 2013

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

scientific article published on 14 July 2011

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

scientific article published on 09 January 2012

Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies.

scientific article published in April 2016

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

scientific article

On the Temperature Dependence of Enzyme-Catalyzed Rates.

scientific article published on 8 March 2016

Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure

scientific article

Peptide cargo tunes a network of correlated motions in human leucocyte antigens

scientific article published on 05 March 2020

Polyubiquitin Drives the Molecular Interactions of the NF-κB Essential Modulator (NEMO) by Allosteric Regulation.

scientific article

Practical aspects on the use of kinetic isotope effects as probes of flavoprotein enzyme mechanisms

scientific article published in January 2014

Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction

scientific article published on July 2010

Reliable <i>In Silico</i> Ranking of Engineered Therapeutic TCR Binding Affinities with MMPB/GBSA

scientific article published on 20 January 2022

Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase.

scientific article published in September 2008

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species.

scientific article

Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling

scientific article published on 03 July 2009

Switching protein metalloporphyrin binding specificity by design from iron to fluorogenic zinc

scientific article published on 18 March 2020

Synthetic Cannabinoid Receptor Agonists Detection Using Fluorescence Spectral Fingerprinting

scientific article published on 03 October 2019

The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO-ubiquitin interactions.

scientific article

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models

article

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