List of works by Janet M Lord

A Life-Raft for Death Signalling?

scientific article published on 01 July 2003

A physiological role for alpha2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells

scientific article

A proposed panel of biomarkers of healthy ageing.

scientific article

Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target

scientific article published on 27 August 2013

Acetylcholinesterase Activity Measurement and Clinical Features of Delirium

scientific article published on 15 December 2016

Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase

scientific article published on December 2013

Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation

scientific article

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

scientific article

Ageing in humans: separating intrinsic ageing from lifestyle effects.

scientific article published in December 2015

Aging of the innate immune system

scientific article

Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study

scientific article published on 27 January 2016

Altered human neutrophil function in response to acute psychological stress.

scientific article published on 18 June 2010

Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture

scientific article published on 19 March 2015

An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity

scientific article published on 19 July 2013

An aged T cell phenotype: a prognostic indicator in liver transplant recipients?

scientific article published on 01 May 2010

An investigation into the relationship between age and physiological function in highly active older adults

scientific article published on 6 January 2015

Anticytomegalovirus antibody titres are not associated with caregiving burden in younger caregivers

scientific article published on 23 April 2014

Bearings in Hip Arthroplasty: Joint Registries vs Precision Medicine: Review Article

scientific article

Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.

scientific article

Bereavement reduces neutrophil oxidative burst only in older adults: role of the HPA axis and immunesenescence

scientific article

Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis

scientific article published on 01 June 2000

Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

scientific article published on 01 September 2019

Cardiorespiratory fitness not sedentary time or physical activity is associated with cardiometabolic risk in active older adults

scientific article published on 10 February 2018

Changes in insulin receptor expression in HL60 cells induced to differentiate towards neutrophils or monocytes

scientific article published on 01 November 1988

Changes in novel haematological parameters following thermal injury: A prospective observational cohort study

scientific article

Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells

scientific article published on 01 June 1995

Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes

scientific article published on 01 September 1991

Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium

scientific article published on 3 February 2006

Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex

scientific article published on 01 June 2007

Clinical review: Statins and trauma--a systematic review

scientific article published on 29 May 2013

Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis

scientific article published in 2022

Conventional and novel PKC isoenzymes modify the heat-induced stress response but are not activated by heat shock

scientific article published on 01 November 1998

Corrigendum to 'Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial' [Vaccine 34 (2016) 2679-2685].

scientific article published on 16 August 2016

Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study

scientific article published on 24 May 2010

Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

scientific article published on 17 February 2010

Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation

scientific article published on February 2002

Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.

scientific article

Dehydroepiandrosterone as a regulator of immune cell function

scientific article published on 12 January 2010

Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation

scientific article published on 19 February 2010

Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol: dehydroepiandrosterone sulphate ratio

scientific article

Depressive symptoms are associated with reduced neutrophil function in hip fracture patients

scientific article published on 20 July 2013

Depressive symptoms post hip fracture in older adults are associated with phenotypic and functional alterations in T cells

scientific article published on 16 December 2014

Development of a screening tool to predict the risk of chronic pain and disability following musculoskeletal trauma: protocol for a prospective observational study in the United Kingdom.

scientific article

Development of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes

scientific article

Diagnostic test accuracy of informant-based tools to diagnose dementia in older hospital patients with delirium: a prospective cohort study

scientific article

Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.

scientific article published on January 2008

Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils

scientific article

Dissociation of caspase-mediated events and programmed cell death induced via HLA-DR in follicular lymphoma.

scientific article

Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock

scientific article

Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum

scientific article (publication date: 2010)

Doppa induces cell death but not differentiation of U937 cells: evidence for the involvement of PKC-beta 1 in the regulation of apoptosis

scientific article published on 01 April 1996

Early events in spontaneous neutrophil apoptosis.

scientific article published on June 2004

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

scientific article

Effect of age on hepatocyte and soleus muscle insulin receptor binding in lean and genetically obese diabetic (ob/ob) mice.

scientific article

Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice ⬇️

scientific article published on August 1, 1983

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. ⬇️

scientific article published in April 2008

Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study

scientific article published on 19 December 2017

Endotheliopathy of Trauma is an On-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study

scientific article published on 22 September 2017

Evidence that precursor cells of monocytes and B-lymphocytes are closely related

scientific article published on 01 October 1989

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.

scientific article

Frailty and sarcopenia: The potential role of an aged immune system

scientific article published on 18 February 2017

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

scientific article

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.

scientific article published in March 2002

Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults.

scientific article published on 26 February 2016

Haemopoiesis: a lottery or genomic determinism?

scientific article published on 01 November 1991

Heparin resistance in severe thermal injury: A prospective cohort study

scientific article published on 20 October 2021

Human innate immunosenescence: causes and consequences for immunity in old age.

scientific article

IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation.

scientific article published in July 2000

IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte-macrophage colony-forming cells ⬇️

scientific article published on July 15, 1995

IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity

scientific article

Immune ageing and susceptibility to Streptococcus pneumoniae

scientific article published on 15 October 2015

Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient

scientific article

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

scientific article published on 30 April 2014

Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes

scientific article published on 17 January 2012

Inflammaging and platelet hyperreactivity: A new therapeutic target?

scientific article published on 01 January 2020

Inflammation, telomere length, and grip strength: a 10-year longitudinal study

scientific article

Ingenol mebutate: induced cell death patterns in normal and cancer epithelial cells.

scientific article

Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis

scientific article published on 01 September 1994

Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta.

scientific article published on August 1999

Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways

scientific article published in July 2003

Innate immunesenescence: underlying mechanisms and clinical relevance

scientific article published on 10 July 2014

Inositol lipids and phosphates in the differentiation of blood cells

scientific article published on 01 January 1990

Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis

scientific article published on 13 October 2005

Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis ⬇️

scientific article published on June 1, 1997

Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).

scientific article published in August 2010

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

scientific article

Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events

scientific article published on 19 July 2011

Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid.

scientific article published on 23 November 2008

Lineage determination during haemopoiesis

scientific article published on 01 January 1987

MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-delta isoenzyme

scientific article published in August 2002

Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction

scientific article published on 19 December 2019

Major depressive disorder, generalised anxiety disorder, and their comorbidity: associations with cortisol in the Vietnam Experience Study

scientific article

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.

scientific article published on 8 March 2018

Markers of inflammatory status are associated with hearing threshold in older people: findings from the Hertfordshire Ageing Study

scientific article published on 14 November 2011

Meeting Report: Recent advances in apoptosis: a report on The Third Euroconference on Apoptosis

scientific article published on 01 April 1996

Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial

scientific article published on 21 April 2016

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

scientific article published on 17 March 2015

NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression

scientific article

Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study

scientific article published on 26 May 2016

Neutrophil ageing and immunesenescence

scientific article (publication date: 30 September 2001)

Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults

scientific article

Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease

scientific article published on January 2013

Neutrophil function and cortisol:DHEAS ratio in bereaved older adults

scientific article published on 21 March 2011

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.

scientific article published on 12 April 2018

Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta

scientific article

Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases.

scientific article

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

scientific article published on 21 April 2005

PKC-δ is an apoptotic lamin kinase

article by Timothy Cross et al published May 2000 in Oncogene

PPARgamma Deficiency Counteracts Thymic Senescence.

scientific article published on 6 November 2017

Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.

scientific article published on September 2000

Phorbol esters showing selective activation of PKC isozymes in vitro regulate thyroid function and insulin-like growth factor binding protein secretion

scientific article published on 01 May 1994

Phorbol myristate acetate treatment of normal human myeloid blast cells promotes monopoiesis and inhibits granulopoiesis

scientific article published on 01 January 1990

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

scientific article

Physical Activity and Nutrition INfluences In ageing (PANINI): consortium mission statement.

scientific article published in September 2017

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Predicting outcome in older hospital patients with delirium: a systematic literature review

scientific article published on 24 August 2015

Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study

scientific article published on 18 July 2017

Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice

scientific article

Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B.

scientific article published on 17 June 2010

Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality.

scientific article

Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

scientific article published on 23 April 2008

Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.

scientific article published on 8 March 2018

Protein kinase C-delta associates with vimentin intermediate filaments in differentiated HL60 cells

scientific article published on 01 June 1996

Protein kinase C: a family of isoenzymes with distinct roles in pathogenesis.

scientific article

Protein phosphorylation in the pancreatic B-cell ⬇️

scientific article published on October 15, 1984

Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Improved by Simvastatin

scientific article published on 28 June 2017

RGD peptides induce apoptosis by direct caspase-3 activation.

scientific article published on February 1999

Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity

scientific article

Reactive oxygen species limit neutrophil life span by activating death receptor signaling

scientific article published on 6 July 2004

Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress

scientific article published on 4 October 2012

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity.

scientific article

Regulation of neutrophil apoptosis: a role for protein kinase C and phosphatidylinositol-3-kinase.

scientific article

Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study

scientific article published on 01 July 2018

Reply from Ross D. Pollock, Norman R. Lazarus, Janet M. Lord and Stephen D. R. Harridge

scientific article published on 01 July 2015

Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

scientific article published on 01 December 2001

Serine/threonine protein kinases and apoptosis.

scientific article

Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta

scientific article published on 01 December 1999

Stochastic or ordered lineage commitment during hemopoiesis?

scientific article published on February 1987

Stress and exercise: Getting the balance right for aging immunity

scientific article published on January 2007

Stress responses and innate immunity: aging as a contributory factor

scientific article published in August 2004

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

scientific article

Superoxide production in human neutrophils: evidence for signal redundancy and the involvement of more than one PKC isoenzyme class.

scientific article published in June 1998

Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200.

scientific article published on 4 April 2012

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line ⬇️

scientific article published on July 1, 1995

Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

scientific article published on January 2006

T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005

scientific article published on 08 November 2006

Telomere-based therapy for immunosenescence.

scientific article published in April 2002

The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation

scientific article published on 01 October 1999

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

scientific article published on 12 July 2012

The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner.

scientific article

The assessment of T-cell apoptosis in synovial fluid.

scientific article published on January 2007

The contribution of leucocytes to the antimicrobial activity of platelet-rich plasma preparations: a systematic review

scientific article published on 6 July 2017

The development of cell lineages: a sequential model.

scientific article published on December 1988

The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review

scientific article

The effect of ageing of the immune system on vaccination responses

scientific article

The effects of cobalt-chromium-molybdenum wear debris in vitro on serum cytokine profiles and T cell repertoire

scientific article

The impact of ageing on natural killer cell function and potential consequences for health in older adults

scientific article published on 6 May 2013

The impact of trauma on neutrophil function

scientific article

The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties.

scientific article published on 29 August 2016

The influence of sex steroid hormones on the response to trauma and burn injury.

scientific article published on 14 September 2017

The lipoxygenase product 13-hydroxyoctadecadienoic acid (13-HODE) is a selective inhibitor of classical PKC isoenzymes

scientific article published on 01 March 1999

The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity

scientific article

The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells

scientific article published on 20 April 2009

The role of protein kinase C in myeloid cell apoptosis.

scientific article published on August 1994

The systemic immune response to trauma: an overview of pathophysiology and treatment

scientific article published on 17 October 2014

Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis

scientific article published in June 2004

Total synthesis of bistramide A and its 36(Z) isomers: differential effect on cell division, differentiation, and apoptosis.

scientific article published on 26 April 2012

Translating longevity research into healthspan

scientific article published on 3 September 2012

Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus

scientific article

Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint

scientific article

Undiagnosed long-term cognitive impairment in acutely hospitalised older medical patients with delirium: a prospective cohort study.

scientific article published on 13 April 2016

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

scientific article

Vitamin D status and its influence on outcomes following major burn injury and critical illness.

scientific article published on 16 April 2018

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