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List of works by Karen E Sheppard

11β-Hydroxysteroid Dehydrogenase 1 Transforms 11-Dehydrocorticosterone into Transcriptionally Active Glucocorticoid in Neonatal Rat Heart ⬇️

scientific article published on January 1, 2002

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

scientific article published in Scientific Reports

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

scientific article

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma

scientific article published on 01 March 2022

Adrenocorticotropin-Releasing Factor Down-Regulates Glucocorticoid Receptor Expression in Mouse Corticotrope Tumor Cells via an Adenylate Cyclase-Dependent Mechanism* ⬇️

scientific article published on August 1, 1991

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

scientific article published on 3 January 2012

CDK4/6 inhibition in cancer: the cell cycle splicing connection

scientific article published on 17 October 2019

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

Combined BRAF, MEK and CDK4/6 inhibition depletes intratumoral immune-potentiating myeloid populations in melanoma

scientific article published on 10 December 2020

Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1.

scientific article

Decreased apparent affinity of corticosterone for colonic crypt glucocorticoid receptors is dependent on the cellular milieu and is distinct from corticosterone metabolism ⬇️

scientific article published on 01 January 1998

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

scientific article

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

scientific article published on 22 June 2016

Differential regulation of type II corticosteroid receptor messenger ribonucleic acid expression in the rat anterior pituitary and hippocampus.

scientific article published in July 1990

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

scientific article published on 7 April 2015

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

scientific article published on 15 May 2019

Functional analysis of genes in regions commonly amplified in high-grade serous and endometrioid ovarian cancer

scientific article published on 29 January 2013

Genome-wide RNAi screen for genes regulating glycolytic response to vemurafenib in BRAFV600 melanoma cells

scientific article published on 12 October 2020

Glucocorticoid Receptor Function in Rat Pituitary Intermediate Lobe is Inhibited by an Endogenous Protein ⬇️

scientific article published on April 1, 1993

Glucocorticoid receptor expression is down-regulated by Lp(a) lipoprotein in vascular smooth muscle cells

scientific article published on 01 September 1995

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

scientific article

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

scientific article

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

scientific article

Metabolic Plasticity in Melanoma Progression and Response to Oncogene Targeted Therapies

scientific article published in 2021

Nuclear receptors. II. Intestinal corticosteroid receptors

scientific article (publication date: May 2002)

Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?

scientific article published on 15 June 2020

Regression of pressure overload-induced left ventricular hypertrophy in mice

scientific article published on 21 January 2005

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

scientific article published on 22 August 2019

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

scientific article

Specific nuclear localization of 11-dehydrocorticosterone in rat colon: evidence for a novel corticosteroid receptor

scientific article published on 01 August 1996

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

scientific article published on 3 September 2013

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours

scientific article published on 13 December 2013

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma

scientific article published on October 2013

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

scientific article published on 18 August 2015

UTP transactivates epidermal growth factor receptors and promotes cardiomyocyte hypertrophy despite inhibiting transcription of the hypertrophic marker gene, atrial natriuretic peptide.

scientific article published on 14 December 2003

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