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List of works by Thomas J. Cradick

A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood.

scientific article published on February 2016

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

scientific article published on 30 December 2013

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

scientific article

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

scientific article

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

scientific article published on 11 August 2013

Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector

scientific article published on January 2014

Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors.

scientific article published on 31 July 2006

DNA targeting specificity of RNA-guided Cas9 nucleases

scientific article (publication date: September 2013)

Defining critical residues in the epitope for a HIV-neutralizing monoclonal antibody using phage display and peptide array technologies.

scientific article published on December 1993

Designing and testing the activities of TAL effector nucleases.

scientific article published in January 2014

Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering

scientific article published on 30 July 2015

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

scientific article

High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter

scientific article published in January 2014

Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models.

scientific article published in January 2014

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.

scientific article published on 8 March 2018

Nanomedicine: tiny particles and machines give huge gains

scientific article published on 03 December 2013

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

scientific article

SAPTA: a new design tool for improving TALE nuclease activity

scientific article published on 16 January 2014

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

scientific article

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

scientific article published on 14 December 2015

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

scientific article published on 05 January 2016

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

scientific article

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

scientific article published on 19 January 2016

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites. ⬇️

scientific article

Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.

scientific article

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