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List of works by Jun Lu

A New Mechanism of Action for the Anticancer Drug Mitomycin C: Mechanism-Based Inhibition of Thioredoxin Reductase ⬇️

scientific article published on June 25, 2012

Activity assays of mammalian thioredoxin and thioredoxin reductase: fluorescent disulfide substrates, mechanisms, and use with tissue samples

scientific article published on 27 December 2013

Biomarkers of adverse response to mercury: histopathology versus thioredoxin reductase activity.

scientific article published on 19 July 2012

Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes ⬇️

scientific article published on January 4, 2011

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.

scientific article published on 29 July 2013

Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning

scientific journal article

High-resolution structures of oxidized and reduced thioredoxin reductase from Helicobacter pylori

scientific article

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

scientific article published on June 2017

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity

scientific article published on April 2006

Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione.

scientific article published on 17 December 2012

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

scientific article published in Scientific Reports

Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.

scientific article

Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase.

scientific article published on 13 December 2011

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

scientific article published on 6 May 2014

Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems

scientific article published on 7 February 2018

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

scientific article published on 15 November 2010

Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier

scientific article (publication date: February 2016)

Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.

scientific article

Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.

scientific article

SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.

scientific article published on April 2010

Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic

scientific article published on 25 May 2018

Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production.

scientific article

Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.

scientific article published on 12 June 2017

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

scientific article

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress

scientific article published on 28 January 2019

The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase

scientific article published on 30 July 2019

The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function

scientific article

The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina

scientific article published on 11 March 2009

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

scientific article published on 31 March 2017

Thioredoxin System in Cell Death Progression ⬇️

scientific article published on June 11, 2012

Thioredoxin-dependent regulation of AIF-mediated DNA damage.

scientific article published on 25 June 2015

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