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List of works by Karl Staples

A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion

scholarly article

A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs

scientific article published on May 2015

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD.

scientific article published on 21 April 2017

Acquired immune responses to the seasonal trivalent influenza vaccination in COPD

scientific article published on 17 June 2019

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients

scientific article published on 17 March 2010

Coadministration of the cyanobacterial lipopolysaccharide antagonist CyP with antibiotic inhibits cytokine production by an in vitro meningitis model infected with Neisseria meningitidis

scientific article published on 14 February 2012

Correction: Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

scientific article published on 25 April 2017

Defining a role for exercise training in the management of asthma

scientific article published on 01 June 2020

Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzae

scientific article published on 29 October 2018

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases

scientific article published on 26 July 2016

Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort

scientific article published on 25 February 2019

Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence

scientific article published on 23 August 2021

Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies

scientific article published on 01 January 2020

Dysregulation of Antiviral Function of CD8(+) T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1-PD-L1 Axis.

scientific article published on 30 October 2015

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma

scientific article

Editorial: Therapeutics for acute lung injury: time to call in the DRs?

scientific article published in February 2017

Expression of p57-Kip2 in monocytes and macrophages

scientific article published on 07 July 2006

Human CD49a Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus

scientific article published on 20 July 2018

Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis During COPD

scientific article published on 07 April 2020

Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells

scientific article

IFNγ Influences Epithelial Anti-viral Responses via Histone Methylation of the Rig-I Promoter.

scientific article

IL-12 and IL-7 synergise to control MAIT cell cytotoxic responses to bacterial infection

scientific article

IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.

scientific article

Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort

scientific article

Increased TNF expression in CD43++ murine blood monocytes

scientific article published on 22 April 2008

Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection

scientific article (publication date: 2016)

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

scientific article

Interrelationships between small airways dysfunction, neutrophilic inflammation and exacerbation frequency in COPD

scientific article published on 24 November 2020

Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

scientific article published on 31 January 2018

Lung macrophages: old hands required rather than new blood?

scientific article

Macrophages and neutrophils: dynamic duo or partners in crime?

scientific article published on 15 February 2018

Making a bad relationship good

scientific article published on 01 August 2019

Manning the Barricades: Lung Fibroblasts and CD4+ T Cells as the Last Line of Defense against Bacterial Invasion?

scientific article published on 01 January 2018

Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages.

scientific article published on 9 June 2015

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.

scientific article

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

scientific article

Novel expression of a functional trimeric fragment of human SP-A with efficacy in neutralisation of RSV.

scientific article

Nuclear factor-kappaB does not mediate the inhibitory effects of dexamethasone on granulocyte-macrophage colony-stimulating factor expression.

scientific article published on April 2004

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

scientific article published on 14 September 2012

RIPOSTE: a framework for improving the design and analysis of laboratory-based research ⬇️

scientific article published on 7 May 2015

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD.

scientific article published on 8 December 2015

Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.

scientific article published on 20 February 2018

Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

scientific article

Reply: The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease.

scientific article published in September 2016

Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records

scientific article published on 17 January 2017

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection

scientific article published on 26 April 2016

Stimulus-Specific Inhibition of IL-5 by cAMP-Elevating Agents and IL-10 Reveals Differential Mechanisms of Action

article

Transcription Factors and Inflammatory Gene Regulation: Strategic Approaches

scientific article published on January 1, 2001

Using Novel Computed Tomography Analysis to Describe the Contribution and Distribution of Emphysema and Small Airways Disease in Chronic Obstructive Pulmonary Disease

scientific article published on 01 August 2019

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36.

scientific article

Viral infection of human lung macrophages increases PDL1 expression via IFNβ.

scientific article published on 16 March 2015

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