List of works by Jeffrey M. Spraggins

A bifunctional nitrone conjugated secondary metabolite targeting the ribosome

scientific article published on 24 July 2020

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry

scientific article

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

scientific article published on 01 August 2020

Automated biomarker candidate discovery in imaging mass spectrometry data through spatially localized Shapley additive explanations

scientific article published on 26 April 2021

Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas

scientific article published on 11 December 2017

Combining MALDI-2 and transmission geometry laser optics to achieve high sensitivity for ultra-high spatial resolution surface analysis

scientific article published on 01 April 2019

Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis

scientific article

Construction and Usage of a Human Body Common Coordinate Framework Comprising Clinical, Semantic, and Spatial Ontologies ⬇️

preprint

Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix.

scientific article published in November 2015

Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium

scientific article

Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles

scientific article

Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI IMS

Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI Imaging Mass Spectrometry

scientific article published on 16 April 2020

Dynamic range expansion by gas-phase ion fractionation and enrichment for imaging mass spectrometry

scientific article published on 26 August 2020

EXIMS: an improved data analysis pipeline based on a new peak picking method for EXploring Imaging Mass Spectrometry data

scientific article

Effect of MALDI matrices on lipid analyses of biological tissues using MALDI-2 postionization mass spectrometry

scientific article published on 01 December 2020

Enhanced Ion Transmission Efficiency up to m/z 24,000 for MALDI Protein Imaging Mass Spectrometry.

scientific article published on 14 February 2018

Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry

scientific article

Fragmentation mechanisms of oxidized peptides elucidated by SID, RRKM modeling, and molecular dynamics

scientific article published on 04 May 2009

High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry

High resolution MALDI imaging mass spectrometry of retinal tissue lipids

scientific article

High spatial resolution imaging mass spectrometry of human optic nerve lipids and proteins

scientific article published on 17 April 2015

High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry

scientific article published on 28 October 2019

High-resolution matrix-assisted laser desorption ionization-imaging mass spectrometry of lipids in rodent optic nerve tissue

scientific article

High-speed MALDI-TOF imaging mass spectrometry: rapid ion image acquisition and considerations for next generation instrumentation

scientific article

Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping

scientific article

Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue

scientific article published on 06 April 2019

Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.

scientific article published in March 2018

Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review

scientific article published on 19 February 2020

Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

scientific article

Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective

scientific article published on 04 July 2020

Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High Resolution Imaging Mass Spectrometry

scientific article published on 06 July 2020

MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data

scientific article

MALDI Imaging Mass Spectrometry Spatially Maps Age-Related Deamidation and Truncation of Human Lens Aquaporin-0.

scientific article published in November 2015

MALDI imaging of lipid biochemistry in tissues by mass spectrometry

scientific article

MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT).

scientific article published in December 2015

Methyltransferase contingencies in the pathway of everninomicin D antibiotics and analogs

scientific article published on 19 July 2020

MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies

scientific article published on 31 May 2019

Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress

scientific article published on 01 September 2020

Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine

scientific article published on 04 September 2020

Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis

scientific article published on 06 April 2016

Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles

scientific article published on 7 April 2015

Peptide ozonolysis: Product structures and relative reactivities for oxidation of tyrosine and histidine residues

scientific article published on 03 July 2006

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

scientific article published on 03 February 2016

Protein Identification in Imaging Mass Spectrometry through Spatially Targeted Liquid Micro-Extractions

scientific article published on 10 December 2017

Protein identification strategies in MALDI imaging mass spectrometry: a brief review

scientific article published on 23 November 2018

Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence

scientific article published on 13 August 2021

Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

scientific article

Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry

scientific article published on 18 August 2020

Response of Hypogean Actinobacterial Genera Secondary Metabolism to Chemical and Biological Stimuli ⬇️

scientific article published in 2018

Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry

scientific article published on 15 July 2020

Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging

scientific article

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

scientific article published in 2021

Spatially Targeted Proteomics of the Host-Pathogen Interface during Staphylococcal Abscess Formation

scientific article published on 03 December 2020

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

scientific article published on 14 October 2019

Targeted multiplex imaging mass spectrometry with single chain fragment variable (scfv) recombinant antibodies

scientific article

The Importance of Clinical Tissue Imaging

scientific article published on 19 April 2019

The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry

scientific article

Trypsin and MALDI matrix pre-coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry

scientific article

Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model of Alport Syndrome

scientific article published on 13 June 2019

Uncovering matrix effects on lipid analyses in MALDI imaging mass spectrometry experiments

scientific article published on 11 February 2020

Use of Single Cell -omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features

scientific article published on 14 May 2020

Viewing the Future of IR through Molecular Histology: An Overview of Imaging Mass Spectrometry

scientific article published on 28 September 2018

Viv: multiscale visualization of high-resolution multiplexed bioimaging data on the web

scientific article published on 11 May 2022

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