List of works - James C Fleet

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1.

scientific article

A general approach to the synthesis of enantiopure 19-nor-vitamin D3 and its C-2 phosphate analogs prepared from cyclohexadienyl sulfone

scientific article published on 01 August 2012

An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research

scientific article

Animal models of colorectal cancer

scientific article

Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

scientific article

Bioavailability and efficacy of vitamin D2 from UV-irradiated yeast in growing, vitamin D-deficient rats

scientific article

Calcium and vitamin D intake maintained from preovariectomy independently affect calcium metabolism and bone properties in Sprague Dawley rats

scientific article published on 17 April 2014

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

scientific article published on 14 March 2014

Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin D Receptor (VDR) From the Distal Intestine and Kidney of Mice.

scientific article published on 24 July 2015

Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells

scientific article

Constitutively active RAS signaling reduces 1,25 dihydroxyvitamin D-mediated gene transcription in intestinal epithelial cells by reducing vitamin D receptor expression

scientific article published on 16 January 2017

Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2 , vitamin D3 , 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.

scientific article

Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate.

scientific article

Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2

scientific article

Effect of phorbol 12-myristate 13-acetate activated signaling pathways on 1α, 25 dihydroxyvitamin D3 regulated human 25-hydroxyvitamin D3 24-hydroxylase gene expression in differentiated Caco-2 cells.

scientific article

Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2.

scientific article

Effects of hindlimb unloading and bisphosphonates on the serum proteome of rats

scientific article

Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.

scientific article

Fluoride-mediated elimination of allyl sulfones: application to the synthesis of a 2,4-dimethyl-A-ring vitamin D3 analogue

scientific article published on 18 May 2012

Forward genetics used to identify new gene Mon1a with critical role in controlling macrophage iron metabolism and iron recycling from erythrocytes

scientific article

GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice

scientific article

Gene-by-Diet Interactions Affect Serum 1,25-Dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice

scientific article published on 20 November 2015

Gene-by-diet interactions influence calcium absorption and bone density in mice.

scientific article

Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine

scientific article

Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells ⬇️

scientific article published on June 8, 2011

Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice

scientific article published on 27 December 2008

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.

scientific article published on 17 October 2011

Luminal glucose does not enhance active intestinal calcium absorption in mice: evidence against a role for Ca(v)1.3 as a mediator of calcium uptake during absorption

scientific article

Molecular actions of vitamin D contributing to cancer prevention

scientific article

Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors

scientific article

NHANES monitoring of serum 25-hydroxyvitamin D: a roundtable summary

scientific article

Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred Mice

scientific article published on 4 December 2015

Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin d-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells ⬇️

scientific article published on March 28, 2012

Regulatory domains controlling high intestinal vitamin D receptor gene expression are conserved in mouse and human

scientific article published on 21 January 2022

Sodium-dependent phosphate uptake in the jejunum is post-transcriptionally regulated in pigs fed a low-phosphorus diet and is independent of dietary calcium concentration.

scientific article

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

scientific article

Systems Genetics of Mineral Metabolism ⬇️

scientific article published on January 26, 2011

Systems genetic analysis of multivariate response to iron deficiency in mice

scientific article published on 28 March 2012

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance is Largely Attributable to Central Adiposity in Overweight and Obese Adults.

scientific article

The effect of 1,25 dihydroxyvitamin D3 treatment on the mRNA levels of β catenin target genes in mice with colonic inactivation of both APC alleles

scientific article

The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2

scientific article published on January 2009

The role of vitamin D in the endocrinology controlling calcium homeostasis

scientific article published on 8 April 2017

Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice ⬇️

scientific article published on October 1, 2012

Vitamin D

scientific article published on 28 June 2011

Vitamin D and cancer: a review of molecular mechanisms ⬇️

scientific article published on January 1, 2012

Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults.

scientific article published in May 2013

List of works by James C Fleet

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1.

A general approach to the synthesis of enantiopure 19-nor-vitamin D3 and its C-2 phosphate analogs prepared from cyclohexadienyl sulfone

An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research

Animal models of colorectal cancer

Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

Bioavailability and efficacy of vitamin D2 from UV-irradiated yeast in growing, vitamin D-deficient rats

Calcium and vitamin D intake maintained from preovariectomy independently affect calcium metabolism and bone properties in Sprague Dawley rats

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin D Receptor (VDR) From the Distal Intestine and Kidney of Mice.

Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells

Constitutively active RAS signaling reduces 1,25 dihydroxyvitamin D-mediated gene transcription in intestinal epithelial cells by reducing vitamin D receptor expression

Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2 , vitamin D3 , 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.

Dietary vitamin D and vitamin D receptor level modulate epithelial cell proliferation and apoptosis in the prostate.

Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2

Effect of phorbol 12-myristate 13-acetate activated signaling pathways on 1α, 25 dihydroxyvitamin D3 regulated human 25-hydroxyvitamin D3 24-hydroxylase gene expression in differentiated Caco-2 cells.

Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2.

Effects of hindlimb unloading and bisphosphonates on the serum proteome of rats

Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.

Fluoride-mediated elimination of allyl sulfones: application to the synthesis of a 2,4-dimethyl-A-ring vitamin D3 analogue

Forward genetics used to identify new gene Mon1a with critical role in controlling macrophage iron metabolism and iron recycling from erythrocytes

GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice

Gene-by-Diet Interactions Affect Serum 1,25-Dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice

Gene-by-diet interactions influence calcium absorption and bone density in mice.

Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine

Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells ⬇️

Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.

Luminal glucose does not enhance active intestinal calcium absorption in mice: evidence against a role for Ca(v)1.3 as a mediator of calcium uptake during absorption

Molecular actions of vitamin D contributing to cancer prevention

Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors

NHANES monitoring of serum 25-hydroxyvitamin D: a roundtable summary

Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred Mice

Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin d-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells ⬇️

Regulatory domains controlling high intestinal vitamin D receptor gene expression are conserved in mouse and human

Sodium-dependent phosphate uptake in the jejunum is post-transcriptionally regulated in pigs fed a low-phosphorus diet and is independent of dietary calcium concentration.

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

Systems Genetics of Mineral Metabolism ⬇️

Systems genetic analysis of multivariate response to iron deficiency in mice

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance is Largely Attributable to Central Adiposity in Overweight and Obese Adults.

The effect of 1,25 dihydroxyvitamin D3 treatment on the mRNA levels of β catenin target genes in mice with colonic inactivation of both APC alleles

The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2

The role of vitamin D in the endocrinology controlling calcium homeostasis

Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice ⬇️

Vitamin D

Vitamin D and cancer: a review of molecular mechanisms ⬇️

Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults.