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List of works by Michael Nassal

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids

scientific article published on 24 July 2019

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

scientific article published in 2022

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond?

scientific article

A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication.

scientific article

A carbene-generating photoaffinity probe for beta-adrenergic receptors.

scientific article published in April 1983

A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula

scientific article published in February 2005

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

scientific article published on 01 June 2020

A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection

scientific article

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

scientific article published on 8 February 2018

A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal.

scientific article published on November 1996

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

scientific article published on 29 July 2015

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

scientific article published on 30 December 2018

Ca2+: the clue to hepatitis B virus X protein function?

scientific article published in September 2002

Carbon-13-N.M.R.-spectra of antamanide, several analogues and their alkali ion complexes

scientific article published on 01 January 1980

Carbonyl J acid derivatives block protein priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids.

scientific article

Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding

scientific article published on 03 October 2007

Chronic hepatitis B: divide and conquer?

scientific article published on 13 July 2017

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

scientific article published on 08 August 2019

Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment

scientific article published on September 1, 1992

Detection of HBV DNA in HBsAg-positive sera after amplification using the polymerase chain reaction

scientific article published on 01 December 1989

Displaying Whole-Chain Proteins on Hepatitis B Virus Capsid-Like Particles

scientific article published on 01 January 2018

Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system.

scientific article published on October 1995

Duck hepatitis B virus: an invaluable model system for HBV infection.

scientific article

Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection.

scientific article published on July 2004

Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.

scientific article

Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells.

scientific article published on December 1995

Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.

scientific article

Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription

scientific article

Evolutionary conservation in the hepatitis B virus core structure: comparison of human and duck cores.

scientific article published on October 1995

Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase

scientific article

Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.

scientific article

Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

scientific article published on November 1998

Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity

scientific article

Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

scientific article

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

scientific article published on 05 June 2015

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro

scientific article published on 13 May 2015

Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference

scientific article

Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

scientific article published on 19 December 2013

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection.

scientific article published on 18 April 2006

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

scientific article published on 19 December 2018

Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.

scientific article published on 18 October 2010

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.

scientific article

Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.

scientific article

Hepatitis B virus replication.

scientific article

Hepatitis B virus replication: novel roles for virus-host interactions.

scientific article

Hepatitis B viruses: reverse transcription a different way.

scientific article published on 12 March 2008

Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies

scientific article

High plasticity of the hepatitis B virus capsid revealed by conformational stress.

scientific article

Host-targeting agents for treatment of hepatitis B virus infection.

scientific article published on 08 August 2015

Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes

scientific article

In vitro assembly of mosaic hepatitis B virus capsid-like particles (CLPs): rescue into CLPs of assembly-deficient core protein fusions and FRET-suited CLPs.

scientific article

Inhibition of Alpha Interferon Signaling by Hepatitis B Virus

scientific article (publication date: 2007)

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication

scientific article published on 18 December 2019

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

scientific article

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

scientific article

Mapping of homologous interaction sites in the hepatitis B virus core protein.

scientific article published on June 1998

Molecular epidemiology and immunology of hepatitis B virus infection - an update.

scientific article

Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure.

scientific article published on 19 September 2007

Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

scientific article published on March 1999

PCR-based site-directed mutagenesis using primers with mismatched 3'-ends.

scientific article published on May 1990

Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids.

scientific article published in September 2000

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

scientific article published on 08 January 2019

Phenotyping hepatitis B virus variants: from transfection towards a small animal in vivo infection model.

scientific article

Phosphorylation and Alternative Translation on Wheat Germ Cell-Free Protein Synthesis of the DHBV Large Envelope Protein

scientific article published on 03 December 2019

Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.

scientific article published on July 1993

Preparative merits of the mixed anhydride (MA) method in the excess use of DDZ-amino acids in the peptide synthesis of biologically active new antamanide analogues.

scientific article published in March 1979

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

scientific article published on April 2010

Quaternary structure is critical for protein display on capsid-like particles (CLPs): efficient generation of hepatitis B virus CLPs presenting monomeric but not dimeric and tetrameric fluorescent proteins.

scientific article published in February 2005

Restriction endonuclease Alw NI is blocked by overlapping Dcm methylation

scientific article published on August 1993

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses

scientific article

Significant interference with hepatitis B virus replication by a core-nuclease fusion protein.

scientific article published on 21 December 2000

Simple confirmatory assay for anti-HBc reactivity.

scientific article

Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

scientific article published on 14 August 2020

Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies

scientific article published on 24 September 2020

Solid-state [13C-15N] NMR resonance assignment of hepatitis B virus core protein.

scientific article published on 16 February 2018

Soluble cysteine-rich tick saliva proteins Salp15 and Iric-1 from E. coli

scientific article published on 24 December 2014

Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus.

scientific article published on 7 July 2006

Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus

scientific article

Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype

scientific article published on 27 October 2018

Suppression of hepatitis B virus antigen production and replication by wild-type HBV dependently replicating HBV shRNA vectors in vitro and in vivo

scientific article

The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly ⬇️

scientific article published on July 1, 1992

The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function ⬇️

scientific article published on August 25, 1993

The level of viral antigen presented by hepatocytes influences CD8 T-cell function.

scientific article published on 3 January 2007

The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes.

scientific article published in January 2004

Topological analysis of the hepatitis B virus core particle by cysteine-cysteine cross-linking.

scientific article published in June 1992

Towards structural studies of self-assembled subviral particles: combining cell-free expression with 100 kHz MAS NMR.

scientific article published on 19 February 2018

Truncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis

scientific article

Whole-Chain Tick Saliva Proteins Presented on Hepatitis B Virus Capsid-Like Particles Induce High-Titered Antibodies with Neutralizing Potential

scientific article published on 9 September 2015

dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.

scientific article

hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase

scientific article

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