List of works - David J. Thornton

A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins.

scientific article published on December 2014

A detection and quantification label-free tool to speed up downstream processing of model mucins

scientific article published on 9 January 2018

A new role for mucins in immunity: insights from gastrointestinal nematode infection.

scientific article published on 27 October 2012

A novel role for Gtb1p in glucose trimming of N-linked glycans.

scientific article

A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis

scientific article published on 01 April 2003

A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis

scientific article (publication date: April 2014)

A sticky end for gastrointestinal helminths; the role of the mucus barrier.

scientific article published on 22 January 2018

A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line.

scientific article published on July 1999

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

scientific article

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

scientific article published on 01 March 2020

An enzyme-linked immunosorbent assay (ELISA) of denatured cartilage link protein

scientific article published on 01 September 1987

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.

scientific article

Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus

article by Sheehan JK et al published 1 December 1995 in American Journal of Respiratory Cell and Molecular Biology

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.

scientific article published on 18 June 2013

Aspergillosis and the role of mucins in cystic fibrosis

scientific article

Assembly of Tim9 and Tim10 into a functional chaperone.

scientific article

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

scientific article published on 28 April 2014

Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units.

scientific article published on May 1996

Biosynthesis of the polymeric gel-forming mucin MUC5B

scientific article

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

scientific article

Changes in the mucosal barrier during acute and chronic Trichuris muris infection.

scientific article

Characterization of neopeptides in equine articular cartilage degradation

scientific article published on 29 June 2015

Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens

scientific journal article

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

scientific article

Cystic fibrosis: an inherited disease affecting mucin-producing organs

scientific article published on 28 March 2014

Desulfurization of mucin by Pseudomonas aeruginosa: influence of sulfate in the lungs of cystic fibrosis patients

scientific article published on 23 August 2012

Detecting, Visualising, and Quantifying Mucins

scientific article published on 01 January 2012

Dropping acid: why is cystic fibrosis mucus abnormal?

scientific article published on 06 December 2018

Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma

scientific article published on 07 May 2009

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates.

scientific article published on 20 July 2012

Extracellular vesicles induce protective immunity against Trichuris muris.

scientific article

Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface

scientific article

Gel-forming and cell-associated mucins: preparation for structural and functional studies

scientific article published on 01 January 2012

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

scientific article published on 13 February 2018

Heterogeneity and size distribution of gel-forming mucins.

scientific article

Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

scientific article published in February 2002

ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites

scientific article published on 03 October 2019

Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin

scientific article published on 01 November 2001

Identification of glycoproteins on nitrocellulose membranes and gels

scientific article published on 01 April 1996

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin

scientific article

Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii

scientific article published on 11 August 2009

Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule

scientific article published on 01 April 1997

Identification of two major populations of mucins in respiratory secretions

scientific article published on 01 September 1994

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

scientific article

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

scientific article

Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface.

scientific article published in January 2004

Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.

scientific article published on 26 March 2018

Intracellular Processing of Human Secreted Polymeric Airway Mucins

scientific article published on 01 November 2018

Isolation and physical characterization of the MUC7 (MG2) mucin from saliva: evidence for self-association.

scientific article published on September 1998

Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10.

scientific article

Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation

scientific article

MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker.

scientific article

MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells

scientific article

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

scientific article published on 14 July 2017

MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease

scientific article published on 05 September 2008

Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization

scientific article published in November 2016

Methods for separation and deglycosylation of mucin subunits

scientific article published on 01 May 1995

Monoclonal antibody recognizing a core epitope on mucin.

scientific article published on October 1998

Muc5ac: a critical component mediating the rejection of enteric nematodes ⬇️

scientific article

Muc5b is required for airway defence

scientific journal article

Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation

scientific article

Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

scientific article

Mucins and their receptors in chronic lung disease

scientific article published on 17 March 2020

Mucins: the frontline defence of the lung

scientific article published on 28 August 2018

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection

scientific article published on 2 November 2015

Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis.

scientific article

Particle tracking microrheology of purified gastrointestinal mucins.

scientific article

Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions

scientific article

Proteomic analysis of mouse growth plate cartilage

scientific article published on 01 December 2006

Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva.

scientific article published on August 2008

Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes

scientific article published on 01 October 1989

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis

scientific article published on 12 December 2013

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP

scientific article published in September 2007

Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols

scientific article

Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product

scientific article published on 01 March 1999

Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies

scientific article (publication date: 6 December 2016)

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

scientific article

Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases.

scientific article published on 18 September 2007

Structure and function of the polymeric mucins in airways mucus.

scientific article

TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.

scientific article published on 18 December 2012

Targeted induction of endoplasmic reticulum stress induces cartilage pathology

scientific article

Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins

scientific article

The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion

scientific article published on 30 September 2019

The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

scientific article published on 22 November 2019

The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module.

scientific article published on 6 April 2007

The expression of mucin genes and the presence of mucin gene products in the equine endometrium

scientific article published on 11 April 2013

The glycosaminoglycans of pig colonic wall connective tissue

scientific article published on 01 May 1983

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

scientific article published on 01 April 2019

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

article

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

scientific article published on 28 August 2017

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

scientific article published on 17 October 2008

Trickle infection and immunity to Trichuris muris

scientific article published on 15 November 2019

Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material.

scientific article

List of works by David J. Thornton

A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins.

A detection and quantification label-free tool to speed up downstream processing of model mucins

A new role for mucins in immunity: insights from gastrointestinal nematode infection.

A novel role for Gtb1p in glucose trimming of N-linked glycans.

A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis

A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis

A sticky end for gastrointestinal helminths; the role of the mucus barrier.

A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line.

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis

An enzyme-linked immunosorbent assay (ELISA) of denatured cartilage link protein

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.

Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.

Aspergillosis and the role of mucins in cystic fibrosis

Assembly of Tim9 and Tim10 into a functional chaperone.

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units.

Biosynthesis of the polymeric gel-forming mucin MUC5B

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

Changes in the mucosal barrier during acute and chronic Trichuris muris infection.

Characterization of neopeptides in equine articular cartilage degradation

Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

Cystic fibrosis: an inherited disease affecting mucin-producing organs

Desulfurization of mucin by Pseudomonas aeruginosa: influence of sulfate in the lungs of cystic fibrosis patients

Detecting, Visualising, and Quantifying Mucins

Dropping acid: why is cystic fibrosis mucus abnormal?

Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates.

Extracellular vesicles induce protective immunity against Trichuris muris.

Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface

Gel-forming and cell-associated mucins: preparation for structural and functional studies

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

Heterogeneity and size distribution of gel-forming mucins.

Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites

Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin

Identification of glycoproteins on nitrocellulose membranes and gels

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin

Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii

Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule

Identification of two major populations of mucins in respiratory secretions

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface.

Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.

Intracellular Processing of Human Secreted Polymeric Airway Mucins

Isolation and physical characterization of the MUC7 (MG2) mucin from saliva: evidence for self-association.

Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10.

Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation

MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker.

MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease

Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization

Methods for separation and deglycosylation of mucin subunits

Monoclonal antibody recognizing a core epitope on mucin.

Muc5ac: a critical component mediating the rejection of enteric nematodes ⬇️

Muc5b is required for airway defence

Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation

Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

Mucins and their receptors in chronic lung disease

Mucins: the frontline defence of the lung

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection

Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis.

Particle tracking microrheology of purified gastrointestinal mucins.

Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions

Proteomic analysis of mouse growth plate cartilage

Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva.

Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP

Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols

Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product

Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases.

Structure and function of the polymeric mucins in airways mucus.