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List of works by Peter J. Tonge

4-Hydroxycinnamoyl-CoA: An Ionizable Probe of the Active Site of the Medium Chain Acyl-CoA Dehydrogenase†

scientific article published on 01 January 2000

A Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis Pathway

scientific article

A Raman-active competitive inhibitor of OMP decarboxylase.

scientific article published on 2 February 2006

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

scientific article

A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors

scientific article published on 14 February 2015

A machine learning-based method to improve docking scoring functions and its application to drug repurposing

scientific article

A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways

scientific article

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

scientific article

A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.

scientific article

A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA

scientific article (publication date: 23 March 2015)

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

scientific article

Another brick in the wall

scientific article published on 01 February 2000

Antibacterial Activity and Mode of Action of a Sulfonamide-Based Class of Oxaborole Leucyl-tRNA-Synthetase Inhibitors

scientific article published on 01 May 2019

Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

scientific article published on 28 September 2016

Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming.

scientific article

BLUF domain function does not require a metastable radical intermediate state

scientific article published on 13 March 2014

CNS Anticancer Drug Discovery and Development Conference White Paper.

scientific article

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery

scientific article published on 13 May 2008

CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

scientific article published on November 2011

Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants

scientific article published on 18 June 2015

Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.

scientific article published on 27 July 2015

Correction to "Machine learning-based method to improve docking scoring functions and its application to drug repurposing"

scientific article published on 28 April 2011

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase

scientific article published on 25 May 2016

Correlating Drug-Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability

scientific article published on 14 February 2020

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation

scientific article

Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin

scientific article

Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis

scientific article

Deacylation and reacylation for a series of acyl cysteine proteases, including acyl groups derived from novel chromophoric substrates.

scientific article

Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging.

scientific article

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis

scientific article published on January 2007

Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids

scientific article

Direct inhibitors of InhA are active against Mycobacterium tuberculosis.

scientific article

Discovery of anti-TB agents that target the cell-division protein FtsZ.

scientific article

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis

scientific article

Drug-Target Kinetics in Drug Discovery.

scientific article

Drug-target residence time: critical information for lead optimization.

scientific article

Editorial overview: Next generation therapeutics

scientific article published on 01 June 2018

Electron transfer quenching in light adapted and mutant forms of the AppA BLUF domain.

scientific article published in January 2015

Electronic Rearrangement Induced by Substrate Analog Binding to the Enoyl-CoA Hydratase Active Site: Evidence for Substrate Activation

article

Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.

scientific article published on 7 June 2011

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

scientific article

Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman, and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.

scientific article published on October 1995

Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein

scientific article published on 10 August 2020

Featured Article Editorial

scientific article published on 12 November 2020

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

scientific article

Forces, bond lengths, and reactivity: fundamental insight into the mechanism of enzyme catalysis

scientific article published on 01 September 1992

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis

scientific article

FtsZ: a novel target for tuberculosis drug discovery

scientific article published on January 2007

Ground state isomerization of a model green fluorescent protein chromophore.

scientific article published in August 2003

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

scientific article published on 01 February 2006

Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa

scientific article published on 11 June 2018

Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata

scientific article

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

scientific article published in July 2000

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

scientific article

Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase.

scientific article

Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity

scientific article published on 01 December 1990

Light-driven decarboxylation of wild-type green fluorescent protein.

scientific article

Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family

scientific article

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus

scientific journal article

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei

scientific article

Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei

scientific journal article

Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents

scientific article

Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions

scientific article published on 26 December 2015

Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member

scientific article

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

scientific journal article

Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A: Effects on Reduction Potential, pKa, and Polarization†

scientific article published on 01 November 2000

Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice

scholarly article by E. A. Weinstein et al published 28 December 2012 in Antimicrobial Agents and Chemotherapy

Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice

scientific article

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents

scientific article

Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy

scientific article published in March 2005

Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues.

scientific article

Photoexcitation of the blue light using FAD photoreceptor AppA results in ultrafast changes to the protein matrix

scientific article published on 4 October 2011

Positron Emission Tomography Imaging with 2-[F]F- p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

scientific article published on 17 August 2018

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target

scientific article published on 19 June 2013

Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.

scientific article published in October 2003

Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis

scientific article

Probing the Ground State Structure of the Green Fluorescent Protein Chromophore Using Raman Spectroscopy†

scientific article published on 01 April 2000

Procatalytic ligand strain. Ionization and perturbation of 8-nitroxanthine at the urate oxidase active site.

scientific article

Protein photochromism observed by ultrafast vibrational spectroscopy.

scientific article published on 30 September 2013

Proteins in action: femtosecond to millisecond structural dynamics of a photoactive flavoprotein

scientific article published on 22 October 2013

Proton relay reaction in green fluorescent protein (GFP): Polarization-resolved ultrafast vibrational spectroscopy of isotopically edited GFP.

scientific article published in November 2006

Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis.

scientific article

Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase

scientific article

Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons

scientific article

Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.

scientific article published in August 1997

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

scientific article

Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.

scientific article

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex

scientific article

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase

scientific article published on 22 February 2017

Resonance Raman spectroscopic and kinetic consequences of a nitrogen ... sulphur enzyme-substrate contact in a series of dithioacylpapains.

scientific article

Ring current effects in the active site of medium-chain Acyl-CoA dehydrogenase revealed by NMR spectroscopy.

scientific article published in June 2005

Roles of Tyrosine 158 and Lysine 165 in the Catalytic Mechanism of InhA, the Enoyl-ACP Reductase fromMycobacterium tuberculosis†

scientific article published on 01 October 1999

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

scientific article published on 02 May 2016

Site-Specific Protein Dynamics Probed by Ultrafast Infrared Spectroscopy of a Noncanonical Amino Acid

scientific article published on 01 November 2019

Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo Activity

scientific article

Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality

scientific article

Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics.

scientific article

Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers

scientific article

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis

scientific article

Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila

scientific article

Structural basis and mechanism of enoyl reductase inhibition by triclosan

scientific article

Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis

scientific article

Structure of Hexadienoyl-CoA Bound to Enoyl-CoA Hydratase Determined by Transferred Nuclear Overhauser Effect Measurements: Mechanistic Predictions Based on the X-ray Structure of 4-(Chlorobenzoyl)-CoA Dehalogenase†

scientific article published on 01 February 1997

Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors

scientific article

Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE

article

Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.

scientific article published in April 2003

Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics

scientific article published on 01 June 2018

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia

scientific article published on 04 September 2009

Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei

scientific article

Substrate recognition by the human fatty-acid synthase.

scientific article published on 7 October 2005

Substrate recognition by β-ketoacyl-ACP synthases.

scientific article published on 17 November 2011

Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores

scientific article published on 01 May 2002

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

scientific article published on 18 April 2008

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis

scientific article published on 31 May 2007

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents

scientific article published on January 2006

Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

scientific article published on January 2012

Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors

scientific article

The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy

scientific article

The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection

scientific article published on 9 November 2012

The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography

scientific article published on 2 February 2017

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity

scientific article published on 17 May 2016

Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy

scientific article published on 10 January 2013

Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

scientific article

Translating slow-binding inhibition kinetics into cellular and in vivo effects

scientific article

Ultrafast Electronic and Vibrational Dynamics of Stabilized A State Mutants of the Green Fluorescent Protein (GFP): Snipping the Proton Wire

scientific article

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii.

scientific article

Ultrafast Vibrational Spectroscopy of the Flavin Chromophore

scientific article published on 01 October 2006

Ultrafast dynamics of protein proton transfer on short hydrogen bond potential energy surfaces: S65T/H148D GFP.

scientific article published in February 2010

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

scientific article published on 4 February 2011

Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants.

scientific article

Ultrafast transient mid IR to visible spectroscopy of fully reduced flavins

scientific article published on 01 September 2011

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

scientific article

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

scientific article published on 27 August 2012

Vibrationally Resolved Photoabsorption Spectroscopy of Red Fluorescent Protein Chromophore Anions

scientific article published on 21 March 2003

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