List of works by Roger Reddel

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

scientific article published on 8 June 2015

A SUMO ligase for ALT

scientific article published on 01 July 2007

A Study of TP53 RNA Splicing Illustrates Pitfalls of RNA-seq Methodology

scientific article published on 20 October 2016

A highly expressed 81 kDa protein in immortalized mouse fibroblast: its proliferative function and identity with ezrin

scientific article published on September 1996

A human bronchial epithelial cell strain with unusualin vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection ⬇️

scientific article published on July 9, 1991

A major functional difference between the mouse and human ARF tumor suppressor proteins

scientific article published on 26 July 2002

A novel human cDNA highly homologous to the fish hormone stanniocalcin

scientific article

A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

scientific article published on January 2005

ATRX represses alternative lengthening of telomeres

scientific article

Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning

scientific article

Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

scientific article

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

scientific article published on September 1995

Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.

scientific article published on April 2004

Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme.

scientific article published in March 2003

Alternative lengthening of telomeres in mammalian cells

scientific article

Alternative lengthening of telomeres in normal mammalian somatic cells

scientific article published on January 2013

Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

scientific article published on April 2004

Alternative lengthening of telomeres, telomerase, and cancer.

scientific article

Alternative lengthening of telomeres: remodeling the telomere architecture

scientific article published on 20 February 2013

Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels

scientific article

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.

scientific article published on 11 June 2010

Assignment of SV40-immortalized cells to more than one complementation group for immortalization

scientific article published on April 1993

Association of extended in vitro proliferative potential with loss of p16INK4 expression.

scientific article

Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.

scientific article published in July 2006

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

scientific article published on 20 November 2019

BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.

scientific article

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

scientific article

Cancer. Cancer and telomeres--an ALTernative to telomerase.

scientific article

Characteristics of tumor cell bioactivity in oncogenic osteomalacia

scientific article published on 01 November 1996

Check your cultures! A list of cross-contaminated or misidentified cell lines

scientific article

Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53

scientific journal article

Comparative analysis of whole genome sequencing-based telomere length measurement techniques

scientific article

Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit

scientific article published on January 2002

Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.

scientific article published on December 2007

Constructing immortalized human cell lines.

scientific article

Control of telomere length by a trimming mechanism that involves generation of t-circles

scientific article published on 12 February 2009

Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases.

scientific article published on November 1998

Correlation between complementation group for immortality and the cellular distribution of mortalin.

scientific article published on January 1995

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours

scientific article published on 27 September 2017

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

scientific article published on 01 December 2009

DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA.

scientific article published on 24 July 2007

DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta

scientific article published on 07 September 2016

Detection of alternative lengthening of telomeres by telomere quantitative PCR.

scientific article published on 25 August 2012

Development of tumorigenicity in simian virus 40-immortalized human bronchial epithelial cell lines

scientific article published on March 1993

Differential display of mRNA.

scientific article

Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres

scientific article

Downregulation of metallothionein-IIA expression occurs at immortalization

scientific article

Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16(INK4a) expression.

scientific article

Enhanced isolation of fibroblasts from human skin explants

scientific article published on 01 October 2012

Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells

scientific article published on January 1991

Expression and localisation of stanniocalcin 1 in rat bladder, kidney and ovary

scientific article published on 01 July 1999

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length

scientific article

Five dysfunctional telomeres predict onset of senescence in human cells

scientific article

Functional dissection of breast cancer risk-associated TERT promoter variants

scientific article published on 26 May 2017

Functional polymorphisms in the TERT promoter are associated with risk of serious ovarian and breast cancer

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers

scientific article

Genes involved in the control of cellular proliferative potential

scientific article published on 01 November 1998

Genetic and functional studies of a germline TP53 splicing mutation in a Li-Fraumeni-like family

scientific article published in June 1998

Genetic differences between the pancytosolic and perinuclear forms of murine mortalin.

scientific article published on August 1996

Germ-line splicing mutation of the p53 gene in a cancer-prone family ⬇️

scientific article published on November 1, 1992

Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten.

scientific article

HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a

scientific article

HPV-16 E6 and E7 genes, like SV40 early region genes, are insufficient for immortalization of human mesothelial and bronchial epithelial cells

scientific article published on August 1994

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein

scientific article (publication date: April 2002)

Human POT1 facilitates telomere elongation by telomerase

scientific article

Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation

scientific article published in June 1988

Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity: a possible mechanism for tumor promotion by asbestos

scientific article published on August 1, 1992

Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats

scientific article

Identification of a 55-kDa ezrin-related protein that induces cytoskeletal changes and localizes to the nucleolus

scientific article

Identification of a novel human mitochondrial D-loop RNA species which exhibits upregulated expression following cellular immortalization.

scientific article published in September 2000

Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2.

scientific article published in June 1998

Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.

scientific article published on 5 February 2007

In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants

scientific article published on March 1994

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

scientific article published on November 1998

Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins

scientific article published on 25 May 2009

Induction of anchorage independent growth and serum resistance in immortalized human bronchial epithelial cells by alteration of the cytoskeleton.

scientific article published on January 1994

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.

scientific article

Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk

scientific article published on 01 September 2020

Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line

scientific article published on April 1989

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

scientific article

Is cell culture a risky business? Risk analysis based on scientist survey data

scientific article

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

scientific article published on November 1997

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

scientific article

Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

scientific article published on August 1998

Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres

scientific article

Mammalian stanniocalcins and cancer

scientific article (publication date: September 2003)

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region

scientific article

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

scientific article published on 4 February 2002

Molecular cloning and characterization of mouse stanniocalcin cDNA.

scientific article published in November 1996

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

scientific article

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

scientific article published on 01 July 2008

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1).

scientific article

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

scientific article published on 24 August 2014

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts

scientific article published on 01 May 2003

PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma

scientific article

Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival.

scientific article published in July 2010

Protein composition of catalytically active human telomerase from immortal cells

scientific article

Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas

scientific article published on 01 May 2001

Reassessment of immortalization complementation group D.

scientific article published on November 1997

Replicative cultures of adult human and rhesus monkey liver epithelial cells

scientific article published on 01 January 1989

Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

scientific article published on June 1999

Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo

scientific article published on August 2002

Role of POT1 in Human Cancer

scientific article published on 24 September 2020

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer

scientific article published on 14 December 2012

SV40-induced immortalization and ras-transformation of human bronchial epithelial cells.

scientific article published on April 1995

Senescence: an antiviral defense that is tumor suppressive?

scientific article

Similar simian virus 40-induced immortalization frequency of fibroblasts and epithelial cells from human large airways.

scientific article published on January 1993

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.

scientific article published on 22 November 2009

Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells ⬇️

scientific article

Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance.

scientific article published on 14 November 2012

Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.

scientific article published in March 2002

Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress.

scientific article published on 6 April 2009

Strategies to enable large-scale proteomics for reproducible research

scientific article published on 30 July 2020

Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

scientific article

Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency

scientific article published on 14 March 2019

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

scientific article published on 11 December 2020

Telomerase activity in pleural malignant mesotheliomas.

scientific article

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

scientific article published on 07 January 2009

Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies

scientific article published in April 2005

Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

scientific article published on 01 September 2006

Telomere biology: a new player in the end zone.

scientific article

Telomere dynamics and telomerase activity in in vitro immortalised human cells ⬇️

scientific article published on April 1, 1997

Telomere elongation in immortal human cells without detectable telomerase activity

scientific article

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

scientific article published on 18 December 2008

Telomere length dynamics in telomerase-positive immortal human cell populations.

scientific article published in March 1998

Telomere maintenance and cancer -- look, no telomerase.

scientific article

Telomere maintenance by recombination in human cells.

scientific article

Telomere maintenance mechanisms and cellular immortalization.

scientific article

Telomere sequence content can be used to determine ALT activity in tumours.

scientific article published on 30 April 2018

Telomere uncapping and alternative lengthening of telomeres

scientific article published on 08 December 2007

The C-Circle Assay for alternative-lengthening-of-telomeres activity.

scientific article

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

scientific article published on 28 May 2019

The first molecular details of ALT in human tumor cells

scientific article

The murine stanniocalcin 1 gene is not essential for growth and development

scientific article

The murine stanniocalcin 2 gene is a negative regulator of postnatal growth

scientific journal article

The role of telomere trimming in normal telomere length dynamics

scientific article published on April 2012

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

scientific article published on June 1997

Transcriptional inactivation of p53 by deletions and single amino acid changes in mouse mot-1 protein

scientific article published on 01 December 2000

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

scientific article published on April 1988

Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes

scientific article published on June 1989

Tumorigenicity of human mesothelial cell line transfected with EJ-ras oncogene

scientific article published in June 1989

Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.

scientific article published on June 2006

Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

scientific article

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

scientific article

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences

scientific article

p16(INK4a) and the control of cellular proliferative life span.

scientific article

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

scientific article published on 17 January 2018

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