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List of works by Gabriella Spengler

5-arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump.

scientific article published on January 2012

Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump.

scientific article

An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators

scientific article

An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells

scientific article published in April 2021

Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes.

scientific article published in July 2018

Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts

scientific article published on 07 January 2019

Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues

scientific article published on 11 December 2020

Antiproliferative Phenanthrenes from <i>Juncus tenuis</i>: Isolation and Diversity-Oriented Semisynthetic Modification

scientific article published on 17 December 2020

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

scientific article published on 01 December 2018

Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides

scientific article published on 22 November 2019

BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections

scientific article published on 08 May 2022

Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria

scientific article published on 28 September 2020

Benzoxazole-based Zn(II) and Cu(II) Complexes Overcome Multidrug-resistance in Cancer

scientific article published on 01 November 2018

Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis.

scientific article published on 19 March 2018

Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria.

scientific article published on 21 February 2018

Biological activity of hydantoin derivatives on P-glycoprotein (ABCB1) of mouse lymphoma cells.

scientific article

Biological activity of persimmon (Diospyros kaki) peel extracts

scientific article published in May 2003

Biological activity of twenty-three hydantoin derivatives on intrinsic efflux pump system of Salmonella enterica serovar Enteritidis NCTC 13349

scientific article published on September 1, 2011

Characterization of intrinsic efflux activity of Enterococcus faecalis ATCC29212 by a semi-automated ethidium bromide method.

scientific article

Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone

scientific article published on 28 February 2019

Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives

scientific article published on 6 January 2018

Computer‐Aided Search for 5‐Arylideneimidazolone Anticancer Agents Able To Overcome ABCB1‐Based Multidrug Resistance

scientific article published on 7 June 2021

Core-shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

scientific article published on 21 January 2020

Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity.

scientific article published on July 2005

Cucurbalsaminones A-C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina, as Multidrug Resistance Reversers

scientific article published on 24 July 2019

Demonstration of the activity of P-glycoprotein by a semi-automated fluorometric method.

scientific article

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

scientific article published on 15 May 2020

Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells

scientific article published in February 2017

Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine

scientific article published on 08 August 2019

Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells.

scientific article published on March 2004

Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro

scientific article published on November 2013

Effective MDR reversers through phytochemical study of Euphorbia boetica

scientific article published on 19 June 2019

Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells.

scientific article published on March 2003

Efflux pump inhibiting properties of racemic phenothiazine derivatives and their enantiomers on the bacterial AcrAB-TolC system

scientific article published on 01 November 2014

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

scientific article published on 03 January 2014

Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells

scientific article published on 2 September 2015

Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines

scientific article published on 11 May 2011

Evaluation of efflux activity of bacteria by a semi-automated fluorometric system

scientific article published on January 2010

Exocyclic Sulfur and Selenoorganic Compounds Towards Their Anticancer Effects: Crystallographic and Biological Studies

scientific article published on 01 August 2018

Exploring Jolkinol D Derivatives To Overcome Multidrug Resistance in Cancer

scientific article

Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter

scientific article published on January 2016

Fluorinated Beta-diketo Phosphorus Ylides Are Novel Efflux Pump Inhibitors in Bacteria.

scientific article published in January 2016

Fluorinated β-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells

scientific article published in November 2015

Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent

scientific article

IL-17E production is elevated in the lungs of Balb/c mice in the later stages of Chlamydia muridarum infection and re-infection

scientific article

Identification and Antimicrobial Susceptibility Testing of Anaerobic Bacteria: Rubik's Cube of Clinical Microbiology?

scientific article

Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype

scientific article published on November 2016

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.

scientific article published on 22 April 2016

Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes

scientific article

In Vitro Evaluation of the Multidrug Resistance Reversing Activity of Novel Imidazo[4,5-b]pyridine Derivatives

scientific article published on 01 July 2018

Inhibition of efflux pumps in methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina

scientific article published on 13 November 2010

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

scientific article published on July 2012

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

scientific article published on 20 August 2020

Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction.

scientific article published on 24 May 2016

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

scientific article published in 2021

Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis

scientific article published on October 1, 2011

Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells.

scientific article published on September 2006

N-substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins

scientific article published on 29 August 2020

New Chalcone Derivative Inhibits ABCB1 in Multidrug Resistant T-cell Lymphoma and Colon Adenocarcinoma Cells

scientific article published on 01 December 2019

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria.

scientific article published on 15 March 2017

New methods for the identification of efflux mediated MDR bacteria, genetic assessment of regulators and efflux pump constituents, characterization of efflux systems and screening for inhibitors of efflux pumps.

scientific article published on September 2008

Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus

scientific article published on 23 January 2019

Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity

scientific article published on 01 July 2019

Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs-A Promising Approach to Fight Cancer Drug Resistance

scientific article published on 18 January 2019

Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity

scientific article published on 6 February 2022

Pharmacophoric features for a very potent 5-spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X-ray analysis

scientific article published on 29 January 2019

Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB.

scientific article published on July 2010

Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy.

scientific article

Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes

scientific article

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities

scientific article published on 03 January 2008

Role of calcium in the efflux system of Escherichia coli.

scientific article

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors

scientific article published on 16 April 2019

Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer

scientific article published on 01 July 2019

Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.

scientific article published on 13 January 2017

Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer

scientific article published on 2 December 2015

Solution equilibrium, structural and cytotoxicity studies on Ru(η6-p-cymene) and copper complexes of pyrazolyl thiosemicarbazones

scientific article published on 22 October 2019

Structure-antiproliferative activity studies on l-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(ii), palladium(ii) and copper(ii) complexes.

scientific article

Substituted steroidal compounds containing amino and amido groups reverse multidrug resistance of mouse T-lymphoma and two human prostate cancer cell lines in vitro

scientific article

Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents

scientific article published on 16 November 2018

Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers

scientific article published on 10 September 2018

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies.

scientific article published on 26 April 2016

The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors

scientific article published on 17 December 2019

The Role of Efflux Pumps and Environmental pH in Bacterial Multidrug Resistance

scientific article published on 01 January 2020

The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus

scientific article published on 01 March 2012

The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria.

scientific article published in January 2004

The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA.

scientific article published on February 2005

The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".

scientific article published on December 2013

Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein.

scientific article

Triterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity ⬇️

[Attempts to reduce drug resistance of bacteria and cancer cells]

scientific article published on 01 June 2007

pH Modulation of efflux pump activity of multi-drug resistant Escherichia coli: protection during its passage and eventual colonization of the colon

scientific article

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