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List of works by Ed C. Lavelle

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

scientific article published on 13 August 2009
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

scientific article published on 3 July 2006
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

scientific article
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

scholarly article
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

scientific article
Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.

scientific article
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

scientific article published on October 2011
Trends in vaccine adjuvants.

scientific article published on April 2011
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.

scientific article
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

scientific article published on 29 February 2016
Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells

scientific article
Immunomodulatory properties of the vaccine adjuvant alum

scientific article published on 23 January 2014
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.

scientific article
Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion

scientific article published on 12 September 2012
Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production

scientific article
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

scientific article published on 5 November 2015
Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

scientific article published on 01 July 2009
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent

scientific article published on 2 January 2004
Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

scientific article published on 23 January 2015
Delivery strategies to enhance oral vaccination against enteric infections.

scientific article published on 25 March 2015
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

scientific article (publication date: 2 April 2014)
The control of protein release from poly(dl-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method

scientific article published on March 31, 1998
Functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation

scientific article published on 10 July 2013
Delivery systems and adjuvants for oral vaccines.

scientific article published on November 2006
Single dose, polymeric, microparticle-based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen

scientific article published on 01 October 1996
Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin

scientific article
The role of CD103⁺ dendritic cells in the intestinal mucosal immune system.

scientific article published on July 2011
Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines

scientific article
Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia

scientific article published on 16 December 2015
Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection.

scientific article published on 30 September 2013
The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants.

scientific article published on March 2010
The identification of plant lectins with mucosal adjuvant activity

scientific article published on 01 January 2001
Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase

scientific article published on 13 July 2012
The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol.

scientific article published in February 1999
Mucosal immunogenicity of plant lectins in mice

scientific article published on 01 January 2000
Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2.

scientific article published in October 2002
Generation of improved mucosal vaccines by induction of innate immunity.

scientific article
IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

scientific article published on 04 November 2015
Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus

scientific article published on 22 November 2013
PLG microparticles stabilised using enteric coating polymers as oral vaccine delivery systems

scientific article published on 01 July 1999
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

scientific article published on 23 January 2014
The distribution of protein associated with poly(??-lactide co-glycolide) microparticles and its degradation in simulated body fluids

scientific article published on January 2, 1998
Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

scientific article
Recent advances in microparticle and nanoparticle delivery vehicles for mucosal vaccination.

scientific article published on January 2012
Immunological implications of the use of plant lectins for drug and vaccine targeting to the gastrointestinal tract.

scientific article published in February 2004
Oral immunization of rainbow trout with antigen microencapsulated in poly(DL-lactide-co-glycolide) microparticles

scientific article published on 01 July 1997
A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma

scientific article published on 23 January 2014
Biodegradable lamellar particles of poly(lactide) induce sustained immune responses to a single dose of adsorbed protein

scientific article published on 01 May 1999

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