Search filters

List of works by Ed C. Lavelle

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

scientific article published on February 2016

A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

scientific article published on 3 July 2006

A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal pathogens.

scientific article published on 5 May 2016

A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma

scientific article published on 23 January 2014

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

scientific article

Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.

scientific article

All things mucosal.

scientific article published in February 2009

An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses

scientific article published on 25 October 2019

Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion

scientific article published on 12 September 2012

Biodegradable lamellar particles of poly(lactide) induce sustained immune responses to a single dose of adsorbed protein

scientific article published on 01 May 1999

Caspase-11 promotes allergic airway inflammation

scientific article published on 26 February 2020

Caspase-11-Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis

scientific article published on 05 June 2019

Delivery strategies to enhance oral vaccination against enteric infections.

scientific article published on 25 March 2015

Delivery systems and adjuvants for oral vaccines.

scientific article published on November 2006

Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent

scientific article published on 2 January 2004

Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

scientific article published on 23 January 2014

Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.

scientific article

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

scientific article published on 23 April 2016

Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells

scientific article

Functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation

scientific article published on 10 July 2013

Generation of improved mucosal vaccines by induction of innate immunity.

scientific article

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

scientific article published on October 2011

Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections.

scientific article published on 27 August 2014

Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia

scientific article published on 16 December 2015

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration

scientific article (publication date: 2 April 2014)

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

scientific article published on 04 November 2015

IL-33 Is a Negative Regulator of Vaccine-Induced Antigen-Specific Cellular Immunity

scientific article published on 14 January 2019

Immunological implications of the use of plant lectins for drug and vaccine targeting to the gastrointestinal tract.

scientific article published in February 2004

Immunomodulatory properties of the vaccine adjuvant alum

scientific article published on 23 January 2014

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

scientific article published on 01 July 2009

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

scientific article

Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer

scientific article published on 22 March 2016

Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

scientific article published on 13 August 2009

Lectins and microparticles for enhanced oral vaccination.

scientific article published in February 2006

Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles

scientific article published on 19 September 2018

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

scientific article published on 5 November 2015

Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2.

scientific article published in October 2002

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

scientific article published on 05 March 2021

Modulation of Immune Responses by Particulate Materials.

scientific article published on 11 May 2016

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

scientific article published on 28 June 2020

Modulation of innate immunity by cyclosporine A

scientific article published on 15 March 2019

Molecules of infectious agents as immunomodulatory drugs.

scientific article published on January 2004

Mucosal immunogenicity of plant lectins in mice

scientific article published on 01 January 2000

Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin

scientific article

Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes

scientific article

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

scientific article

NLRP3 in protective immunity and vaccination against respiratory infection

scientific article published on 01 March 2011

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

scientific article published on 23 January 2015

Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection.

scientific article published on 30 September 2013

Oral immunization of rainbow trout with antigen microencapsulated in poly(DL-lactide-co-glycolide) microparticles

scientific article published on 01 July 1997

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase

scientific article published on 13 July 2012

PLG microparticles stabilised using enteric coating polymers as oral vaccine delivery systems

scientific article published on 01 July 1999

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

scientific article

Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells

scientific article

Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines

scientific article

Promotion of trained innate immunity by nanoparticles

scientific article published in 2021

Recent advances in microparticle and nanoparticle delivery vehicles for mucosal vaccination.

scientific article published on January 2012

Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.

scientific article

Single dose, polymeric, microparticle-based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen

scientific article published on 01 October 1996

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

scientific article

Targeted Strategies for Mucosal Vaccination

scientific article

Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus

scientific article published on 22 November 2013

Technological Approaches for Improving Vaccination Compliance and Coverage

scientific article published on 16 June 2020

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

scientific article published on 29 February 2016

The control of protein release from poly(dl-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method ⬇️

scientific article published on March 31, 1998

The distribution of protein associated with poly(??-lactide co-glycolide) microparticles and its degradation in simulated body fluids ⬇️

scientific article published on January 2, 1998

The identification of plant lectins with mucosal adjuvant activity

scientific article published on 01 January 2001

The immune response to a model antigen associated with PLG microparticles prepared using different surfactants

scientific article published on 01 December 1997

The role of CD103⁺ dendritic cells in the intestinal mucosal immune system.

scientific article published on July 2011

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.

scientific article

The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants.

scientific article published on March 2010

The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation

scientific article

The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol.

scientific article published in February 1999

The synthesis and biological evaluation of mycobacterial p-hydroxybenzoic acid derivatives (p-HBADs)

scientific article published on 01 February 2014

The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses.

scientific article published on 19 January 2018

Trends in vaccine adjuvants.

scientific article published on April 2011

Type I IFN signalling is required for cationic adjuvant formulation (CAF)01-induced cellular immunity and mucosal priming

scientific article published on 11 November 2019

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

scholarly article

Paulina is supported by:

About Paulina

Help